Continuous Temperature-Monitoring Skin Patch Effective for Detecting Febrile Neutropenia Earlier
February 8th 2019According to a study abstract presented at the 60th American Society of Hematology Annual Meeting & Exposition, using a skin patch for continuous temperature monitoring is feasible in the inpatient setting and has the potential to detect febrile neutropenia earlier.
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In 2015, the Neulasta On-Body Injector (OBI) Onpro device was introduced as a less costly method of pegfilgrastim administration. While the device has been found to be safe in healthy volunteers and have pharmacokinetics similar to that of traditional pegfilgrastim, there have been limited data comparing the 2 methods.
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Over the Past 2 Decades, Use of G-CSF in Non-Hodgkin Lymphoma Increased Significantly
February 1st 2019Among older patients with non-Hodgkin lymphoma receiving myelosuppressive chemotherapy, use of primary prophylaxis with granulocyte colony-stimulating factor (G-CSF) increased significantly over the past 20 years.
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PCT Just as Effective as MASCC for Predicting Serious Complications in Febrile Neutropenia
January 19th 2019A single measurement of procalcitonin (PCT) is comparable to Multinational Association for Supportive Care in Cancer (MASCC) score for predicting serious medical complications in patients with cancer with febrile neutropenia.
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Study Finds CISNE Model Effective for Guiding Treatment-Setting Decisions for Febrile Neutropenia
January 9th 2019A new study comparing 2 risk stratification models found that the Clinical Index of Stable Febrile Neutropenia (CISNE) Model is useful for identifying low-risk patients with febrile neutropenia, but the combination of the CISNE Model with the Multinational Association of Supportive Care in Cancer Risk Index Score may help emergency physicians cope with febrile neutropenia more confidently.
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Neutropenia Independently Associated With Poor Outcomes, but Not When Treated With G-CSF
December 28th 2018Despite a meaningful survival, neutropenia is independently associated with poor outcomes among critically ill patients with cancer, according to a new study. However, neutropenia was no longer significantly associated with outcome in patients treated with granulocyte colony-stimulating factor (G-CSF), suggesting a beneficial impact of the treatment.
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Similar Incidence Rates of Febrile Neutropenia Between Short- and Long-Acting G-CSFs
December 27th 2018Incidence of febrile neutropenia, hospitalizations, and chemotherapy dose reductions and/or delays were similar between short- and long-acting granulocyte-colony stimulating factors, according to a meta-analysis of randomized controlled trials.
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Studies Find High Prevalence, Cost of Neutropenia in Pediatric Patients With Autoimmune Disease
December 18th 2018Pediatric patients with autoimmune neutropenia have a higher prevalence and cost than previously suspected, according to the results of 2 studies presented at the 60th American Society of Hematology Annual Meeting & Exposition, held December 1-4 in San Diego, California.
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Severe Neutropenia May Predict Survival Outcomes in Patients With Pancreatic Cancer
December 5th 2018Among patients with pancreatic cancer being treated with modified FOLFIRINOX, those who develop severe neutropenia have significantly longer median overall survival, as well as longer time to treatment failure, compared with those who do not develop severe neutropenia.
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Outpatient ASCT Safe, Results in Lower Rates of Febrile Neutropenia and Septicemia
November 29th 2018Patients who undergo outpatient autologous stem cell transplantations (ASCTs) not only report lower costs and higher satisfaction, but they also have lower odds of developing febrile neutropenia and septicemia than patients who undergo inpatient ASCT, according to the results of a new analysis.
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Assessment Can Help ED Physicians Predict Poor Prognosis for Patients With Febrile Neutropenia
November 17th 2018The quick sequential (sepsis-related) organ failure assessment can help emergency department physicians identify which patients with neutropenia are at risk of a poor prognosis and should receive prompt empirical antimicrobial therapy, according to a new study.
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Study Identifies High Burden of Invasive Infections in Neutropenic Patients
November 15th 2018One-third of neutropenic patients developed invasive infection following intensive chemotherapy, which was significantly associated with an increase in mortality up to 100 days after the start of neutropenia.
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Characteristics and Management of Patients With Febrile Neutropenia
November 10th 2018Seeking to determine how FN is managed in most referral hospitals in Iran, researchers studied patients hospitalized during a 6-month period, also taking into account characteristics of FN patients and the risk factors associated with FN development.
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Cytarabine, Aclarubicin, and G-CSF Effective Treatment Regimen for Relapsed/Refractory AML
November 3rd 2018Cytarabine, aclarubicin, and granulocyte colony-stimulating factor (CAG) generates a positive effect for patients with acute myeloid leukemia (AML) by decreasing the number of immunosuppressive cell types and their associated cytokines, while also downregulating SDF-1α levels
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Colony-Stimulating Factors Can Help Treat, Prevent Clozapine-Induced Neutropenia or Leukopenia
October 24th 2018A case report has revealed that clozapine with intermittent colony-stimulating factors helped treat leukopenia and neutropenia in a patient with chronic paranoid schizophrenia who responds only to clozapine.
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