Bipolar disorder affects many aspects of an individual's life and greatly interferes with a person's ability to find and maintain employment. The evidence indicates that a majority of patients with bipolar disorder are not employed and many others are employed only part time. Job-related difficulties are common, and patients with bipolar disorder tend to have higher rates of absenteeism from work compared with working individuals without bipolar disorder. A limited amount of data suggests that appropriate treatment may improve occupational status among patients with bipolar disorder. The ability to work is closely related to functional recovery, which tends to be incomplete in a majority of patients with bipolar disorder.
(Am J Manag Care. 2005;11:S91-S94)
Bipolar disorder affects virtually every aspect of a patient's life, resulting in a high socioeconomic burden. Estimates of the condition's cost to society range are as high as $45 billion annually. The vast majority of the total comes from indirect costs, which include reduced productivity, work loss, and unemployment.1
Bipolar disorder is associated with high rates of unemployment and job-related difficulties. A survey by the National Depressive and Manic-Depressive Association showed that approximately 60% of individuals with bipolar disorder were unemployed, even among patients with college degrees. Additionally, 88% of the respondents reported occupational difficulties.2 Data from a large registry of patients with bipolar disorder also demonstrated an unemployment rate of about 60%.3 Data from a US national sample showed that self-reported bipolar disorder was associated with a 40% reduction in the likelihood of paid employment.4
Studies of Work Impairment and Loss
A number of smaller studies also have documented high rates of unemployment. Six-month follow-up of a group of patients hospitalized for a manic episode showed that only 43% of patients were employed, although 80% were symptom free or mildly symptomatic.5 Another group of patients hospitalized for mania were evaluated 1.7 years later, and 42% of the patients reported having steady employment throughout the follow-up period. Moreover, 23% had been unemployed for the entire period.6 A 5-year follow-up of a group of patients with bipolar disorder showed that 62% were employed in the year before the study, which was significantly less than what was found among a comparison sample of persons without a mood disorder.7
Another study related employment status to cognitive functioning.8 The study involved 117 patients with bipolar disorder, who underwent a battery of cognitive and symptom assessments. The study showed that more than 50% of the patients were unemployed, and only 27% had competitive full-time employment. Current employment status was significantly associated with cognitive functioning, particularly immediate verbal memory. Other factors that influenced employment status were total symptom severity, history of psychiatric hospitalization, and maternal education. In the National Institute of Mental Health Systematic Treatment Enhancement Program for Bipolar Disorders, among patients who entered in a depressive episode, whereas educational achievement was high (with 82% either having graduated from college or having some college study), annual income was low, with 91% having earned less than $30 000 in the previous year (Hong Wei Zhang, written communication, February 2005).
Among employed individuals with bipolar disorder, absenteeism from work often poses problems. A study of primary care patients showed that a diagnosis of bipolar disorder was associated with a 7-fold likelihood of missing work because of illness.9
A recent literature review identified 14 studies that evaluated work impairment among individuals with bipolar disorder.10 The studies found in the literature search focused on work impairment expressed as long-term unemployment, occupational functioning, absenteeism because of emotional problems and somatic complaints, and poor work performance. Each of the parameters was observed more often among patients with bipolar disorder, even when compared with people with other types of mental illness.
Treatment and Costs
The literature review uncovered a limited amount of evidence to suggest that treatment improves health-related quality of life and functioning while reducing healthcare resource utilization and cost.10 One study found that patients who achieved standard lithium serum levels had better work performance compared with patients who had low lithium serum levels, suggesting that undertreatment can have a negative impact on occupational functioning.11 A more recent study found that patients who receive higher doses of quetiapine might have reduced utilization of mental health resources.12 Another study compared the impact of olanzapine versus haloperidol on occupational functioning. After 12 weeks of treatment, the olanzapine group had slight improvement in work impairment and health-related quality of life, which was not seen in patients treated with haloperidol. However, only about 50% of the treated patients maintained their work status.13 Group psychotherapy as an adjunct to medication has been found to improve impairment associated with school, housework, employment, and training.14
The costs associated with work loss were recently evaluated, using an employer-based database.15 The analysis showed that the average annual absence in hours, short-term disability payments, and worker compensation payments were significantly greater compared with a control group without a diagnosis of bipolar disorder. Moreover, short-term disability payments were higher for patients with bipolar disorder than for those with major depression. The authors concluded that patients with bipolar disorder may exhaust their sick leave and go onto short-term disability more frequently than patients with major depression.
Factors Affecting Work Status
Additional studies have evaluated rehabilitation, training, and other factors that influence occupational status and job performance. One study looked at employment outcomes among patients with psychiatric disabilities who received job-seeking skills and logistical support during their job search.16 The study found that 36% of patients either obtained a job or entered a job training program. Patients were more likely to obtain employment if they had a good work history, good job interviewing skills, and nonpsychotic diagnoses.
The effects of vocational rehabilitation were evaluated in another study involving 149 patients with severe mental illness.17 The patients were followed for 18 months as investigators evaluated the impact of work on symptoms, quality of life, and self-esteem. On the basis of their predominant work activity during the study period, the patients were separated into 4 groups: competitive work, sheltered work, minimal work, and no work. The evaluation showed that competitive work was associated with greater improvement in symptoms, self-esteem, and satisfaction with vocational services, leisure, and finances compared with patients in the minimal- work and no-work groups. No such advantages were seen in the sheltered-work group.