• Center on Health Equity and Access
  • Clinical
  • Health Care Cost
  • Health Care Delivery
  • Insurance
  • Policy
  • Technology
  • Value-Based Care

Dr Roland Chen Discusses the Primary Endpoints of the GUARD-AF Trial for Atrial Fibrillation

Video

The GUARD-AF trial will allow us to look at both the benefits and the risks of screening for atrial fibrillation and the reduction of stroke, said Roland Chen, MD, MS, vice president and head of clinical development for innovative medicines at Bristol-Myers Squibb.

The GUARD-AF trial will allow us to look at both the benefits and the risks of screening for atrial fibrillation and the reduction of stroke, said Roland Chen, MD, MS, vice president and head of clinical development for innovative medicines at Bristol-Myers Squibb.

Transcript

What are some of the primary endpoints being sought by the GUARD-AF trial? How are healthcare claims being utilized to distinguish evidence on health outcomes associated with atrial fibrillation?

The primary efficacy endpoint in GUARD-AF is actually stroke that leads to a hospital evaluation. The primary safety endpoint in GUARD-AF is bleeding that leads to hospitalization. So, GUARD-AF will actually allow us to look at both the benefits and the risks of screening for atrial fibrillation and the reduction of stroke. Healthcare claims are important in this study, because healthcare claims will actually be used to identify the occurrence of these primary endpoints because these patients are receiving Medicare as their health insurance. So this study, although it's a clinical study where patients are randomized, is actually being conducted in a real world setting. So, healthcare claims will be an important part of this pragmatic trial.

Related Videos
Shawn Kwatra, MD, dermatologist, John Hopkins University
Dr Laura Ferris Discusses Safety, Efficacy of JNJ-2113 in Patients with Plaque Psoriasis
dr krystyn van vliet
Martin Dahl, PhD, senior vice president, AnaptysBio
Jeff Stark, MD, vice president, head of medical immunology, UCB.
Jonathan Silverberg, MD, PhD, MPH, FAAD, professor of dermatology, director of clinical research and patch testing, George Washington University School of Medicine and Health Sciences
Monica Li, MD, University of British Columbia
Robert Sidbury, MD, MPH, FAAD, professor of pediatrics, division head of dermatology, Seattle Children's Hospital, University of Washington School of Medicine
Raj Chovatiya, MD, PhD, associate professor at the Rosalind Franklin University Chicago Medical School, founder and director of the Center for Medical Dermatology and Immunology Research
Related Content
© 2024 MJH Life Sciences
AJMC®
All rights reserved.