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Evidence-Based Oncology December 2015
Three Proposals to Reform the 340B Drug Discount Program
Rena M. Conti, PhD; Peter B. Bach, MD, MAPP; Michael Kolodziej, MD
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Is There a Mathematical Resolution to the Cost-Versus-Value Debate?
Bruce Feinberg, DO; Lincy S. Lal, PharmD, PhD; J. Michael Swint, PhD
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Is There a Mathematical Resolution to the Cost-Versus-Value Debate?

Bruce Feinberg, DO; Lincy S. Lal, PharmD, PhD; J. Michael Swint, PhD
Solutions proposed by patient advocates and physicians to control costs provide approaches to valuing new drug/treatments compared with 1 or several prevailing standards of care. Increasingly, however, the debate over cost is transitioning to a debate over value.
The projections for the rising cost of cancer care have spurned robust dialogue from every sector of the healthcare economy.1 Among the many targets for cost control are the rising cost of cancer specialty drugs—drugs distinguished by their route of administration, synthesis or bioengineering, mechanism of action, cost, etc.2 Although there are examples of market forces and competition emerging to tamp down prices to more acceptable levels (eg, pharmacy benefit manager negotiations for hepatitis C drugs), stakeholders seem impatient for these market-based solutions.3

Payer approaches to specialty drug cost control have included, but are not limited to:

Bundled reimbursement

Episode-of-care reimbursement

Restricted clinical pathways

Product tiering

Step edits.

Proposed policy approaches to specialty drug cost control have included, but are not limited to:

Empowering Medicare to negotiate drug prices (as the Veteran’s Administration does)

Allowing the importation of drugs for personal use

Reforming the patent system to combat so-called pay-for-delay settlements between brand and generic drug makers.

Solutions proposed by patient advocates and physicians aim to control costs by providing standardized approaches to valuing new drug/treatments compared with 1 or several prevailing standards of care. Increasingly, the debate over cost is transitioning to a debate over value, but the value of cancer drugs—in what is often a complex multi-modality treatment of a terminal disease—is complicated to say the least.4,5


Thus far 2 provider organizations, one a professional society and the other a cancer center, have developed a value-based cancer care model geared to the patient and the provider. These models were recently made available for peer and public review. A third was previewed with limited content restricted to 2 less-prevalent cancer diagnoses.

The American Society of Clinical Oncology (ASCO) announced its Value Framework in June 2015, which is designed to help physicians and patients assess specialty drug treatments based on their clinical benefit, side effects, and cost. ASCO’s approach is thus far unique, released to the public and professional community using a peer-reviewed publication that included extensive background and content on methodology. Schnipper et al have detailed the nuances of the Value Framework, developed by ASCO’s Value in Cancer Care Task Force, in the Journal of Clinical Oncology.6 The framework is expected to be applied by medical oncologists to assess the relative value of cancer therapies, in various clinical scenarios, as an element in the shared decision-making process with their patients.

In the same week, an interactive online tool developed by Peter B. Bach, MD, director of the Center for Health Policy and Outcomes at Memorial Sloan Kettering Cancer Center (MSKCC), was also made public. The DrugAbacus calculator attempts to place drug costs in line with their overall value (FIGURES 1 and 2). The calculator has primarily been developed as a tool for research and information only, but critics and supporters believe it “may be utilized by physicians to start a conversation discussing the value of chemotherapy agents with their patients.” However, the authors clearly state it is purely informational and should not be used to guide decision making.7

More recently, the National Comprehensive Cancer Network (NCCN) provided a preview of its Evidence Blocks via mainstream media and its website. The Evidence Blocks, for now, are limited to multiple myeloma (MM) and chronic myeloid leukemia (CML). The NCCN Evidence Blocks are published in a new version of the NCCN Guidelines and are intended as a visual representation of 5 key value measures: efficacy, expected associated toxicities, and the quality, quantity, and consistency of the evidence that provide important information about specific NCCN Guidelines recommendations (FIGURE 3).8

Other strategies aiming to gauge cancer-drug value are under development by the European Society of Medical Oncology and the Boston-based Institute for Clinical and Economic Review (ICER). ICER recently announced it had received a $5.2 million grant from the Laura and John Arnold Foundation to produce 15 to 20 reports on the value of major new drugs approved by the FDA.9 Understanding the similarities, differences, and potential limitations of these approaches to calculate cancer-drug value will be critical to their adoption and appropriate use.


Interpreting value relative to cost, what is often also referred to as cost-effectiveness, is not a new concept in healthcare. For over 2 decades, cost-effectiveness analyses, particularly in the United States, have used a figure of $50,000 per life-year or quality-adjusted life-year (QALY) gained as a threshold for affirming the cost-effectiveness of an intervention. The history of this practice is ill defined, although it has been linked to the end-stage renal disease kidney dialysis cost-effectiveness literature that dates back to 1968.10 The use of $50,000 as a benchmark for assessing the cost-effectiveness of an intervention first emerged in 1992 and became widely used after 1996.11 Critics have argued that this figure is arbitrary, that its appeal lies more in the convenience of a round number rather than in the current value of renal dialysis or in stakeholder assessment.12 Nonetheless, cost-effectiveness or value analyses of healthcare interventions have an extensive history.

The confusion inherent to the casual interchangeable use of terms like quality, value, and cost-effectiveness was clarified in a seminal report published in 2002 by the Institute of Medicine (IOM), Crossing the Quality Chasm.13 This influential work framed all future discussions of quality healthcare. In the report, IOM outlined 6 specific aims that a healthcare system must fulfill to deliver quality care:

1. Safe: care should be as safe for patients in healthcare facilities as in their homes.

2. Effective: the science and evidence behind healthcare should be applied and serve as the standard in the delivery of care.

3. Efficient: care and service should be cost-effective and waste should be removed from the system.

4. Timely: patients should not experience waits or delays in receiving care and service.

5. Patient-centered: the system of care should revolve around the patient, respect patient preferences, and put the patient in control.

6. Equitable: unequal treatment should be a fact of the past; disparities in care should be eradicated.

Although the focus of the IOM report was not the medical intervention itself, but the healthcare system delivering it, its conclusions broadened value concepts for interventions beyond safety and efficacy. Cancer-care value assessments, which historically have focused on efficacy and toxicity, have been informed by this seminal work. Patient-centered aspects of treatment value like route, frequency, and site of administration are now routinely considered. The IOM’s report on quality and the legacy of research using QALYs serve as a foundation on which these new value tools can be evaluated.


The authors of the ASCO Value Framework have attempted to define value in terms of 3 of the 6 IOM elements of quality healthcare delivery: efficacy (clinical benefit), safety (toxicity), and efficiency (cost). They have chosen to use “net health benefit” (NHB), which is the difference in mean effectiveness of a new treatment compared with a standard, as the aggregated metric for a value assessment in this tool. NHB is composed of 3 elements: clinical benefit (max 80% contribution), toxicity (+/- 20% contribution), and bonus points (maximum, 30). Clinical benefit is assigned a score between 1 and 5 based on the fractional improvement in overall survival (OS) or if not available, progression-free survival (PFS) based on a specific clinical scenario comparator. The clinical benefit score is then multiplied by a weighting factor (16 for OS and 11 for PFS). Toxicity is also assigned a categorical value ranging between –20 and +20 based on fractional decrease or increase in grade 3 to grade 5 toxicities of the comparator. Finally, bonus points can be awarded for differential symptom palliation or treatment-free interval.

The task force has decided to display NHB as a separate calculation without the cost factored in so that physicians and patients can view the clinical information independent of the cost. Although this methodology deviates significantly from formal economic analysis, it may feel more realistic to both the physician and the patient who are focused on a very specific clinical scenario.

The DrugAbacus uses 4 of the 6 parameters outlined by the IOM for quality healthcare delivery: efficacy (clinical benefit), safety (tolerability), efficiency (cost), and equity (rarity and population burden). Only timeliness and patient centeredness are not considered.

The 6 specific attributes that DrugAbacus does consider in value determination, include: efficacy, toxicity, novelty, development cost, disease rarity, and population burden—all at the individual drug level. In this tool, as in the ASCO framework, efficacy is measured in terms of OS; if OS is not available, then PFS or response rate are used as a surrogate, but modified by a level of evidence grade into an estimated OS benefit. Toxicity scoring has 2 components: differential proportion of grade 3 to 4 adverse events (AE) and differential probability of drug discontinuation due to AE. The user determines the weight of each of the components. For example, the user must determine the value of efficacy in order to output a price, and can also manipulate the weight of the other factors. The output is dependent solely on how the user values each of those 6 attributes.

The NCCN Evidence Blocks are in development, but from the information currently available, value determination is regimen-based, rather than drug-based, and comprises the following:

Efficacy of regimens

Safety of regimens

Quality and quantity of evidence for regimens

Consistency of evidence for regimens

Affordability of regimens

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