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The American Journal of Managed Care January 2011
Hypertension Treatment and Control Within an Independent Nurse Practitioner Setting
Wendy L. Wright, MS; Joan E. Romboli, MSN; Margaret A. DiTulio, MS, MBA; Jenifer Wogen, MS; and Daniel A. Belletti, MA
Relationship Between Short-Acting β-Adrenergic Agonist Use and Healthcare Costs
Harris S. Silver, MD; Christopher M. Blanchette, PhD; Shital Kamble, PhD; Hans Petersen, MS; Matthew A. Letter, BS; David Meddis, PhD; and Benjamin Gutierrez, PhD
Healthcare Costs and Nonadherence Among Chronic Opioid Users
Harry L. Leider, MD, MBA; Jatinder Dhaliwal, MBA; Elizabeth J. Davis, PhD; Mahesh Kulakodlu, MS; and Ami R. Buikema, MPH
A System-Based Intervention to Improve Colorectal Cancer Screening Uptake
Richard M. Hoffman, MD, MPH; Susan R. Steel, RN, MSN; Ellen F. T. Yee, MD; Larry Massie, MD; Ronald M. Schrader, PhD; Maurice L. Moffett, PhD; and Glen H. Murata, MD
Relationship Between Patient Satisfaction With Inpatient Care and Hospital Readmission Within 30 Days
William Boulding, PhD; Seth W. Glickman, MD, MBA; Matthew P. Manary, MSE; Kevin A. Schulman, MD; and Richard Staelin, PhD
Effects of Health Savings Account Eligible Plans on Utilization and Expenditures
Mary E. Charlton, PhD; Barcey T. Levy, PhD, MD; Robin R. High, MBA, MA; John E. Schneider, PhD; and John M. Brooks, PhD
Health Plan Resource Use Bringing Us Closer to Value-Based Decisions
Sally Elizabeth Turbyville, MA, MS; Meredith B. Rosenthal, PhD; L. Gregory Pawlson, MD; and Sarah Hudson Scholle, DrPH
Telephone-Based Disease Management: Why It Does Not Save Money
Brenda R. Motheral, PhD
Economic Model for Emergency Use Authorization of Intravenous Peramivir
Bruce Y. Lee, MD, MBA; Julie H. Y. Tai, MD; Rachel R. Bailey, MPH; Sarah M. McGlone, MPH; Ann E. Wiringa, MPH; Shanta M. Zimmer, MD; Kenneth J. Smith, MD, MS; and Richard K. Zimmerman, MD, MPH
High-Deductible Health Plans and Costs and Utilization of Maternity Care
Katy Backes Kozhimannil, PhD, MPA; Haiden A. Huskamp, PhD; Amy Johnson Graves, MPH; Stephen B. Soumerai, ScD; Dennis Ross-Degnan, ScD; and J. Frank Wharam, MB, BCh, MPH
High-Deductible Health Plans and Costs and Utilization of Maternity Care
Katy Backes Kozhimannil, PhD, MPA; Haiden A. Huskamp, PhD; Amy Johnson Graves, MPH; Stephen B. Soumerai, ScD; Dennis Ross-Degnan, ScD; and J. Frank Wharam, MB, BCh, MPH
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Telephone-Based Disease Management: Why It Does Not Save Money
Brenda R. Motheral, PhD

Telephone-Based Disease Management: Why It Does Not Save Money

Brenda R. Motheral, PhD
To generate cost savings, plan sponsors should implement transitional care programs and disease management programs that consider risk, actionability, treatment and program effectiveness, and costs.

Objectives: To understand why the current telephone-based model of disease management (DM) does not provide cost savings and how DM can be retooled based on the best available evidence to deliver better value.


Study Design: Literature review.


Methods: The published peer-reviewed evaluations of DM and transitional care models from 1990 to 2010 were reviewed. Also examined was the cost-effectiveness literature on the treatment of chronic conditions that are commonly included in DM programs, including heart failure, diabetes mellitus, coronary artery disease, and asthma.


Results: First, transitional care models, which have historically been confused with commercial DM programs, can provide credible savings over a short period, rendering them low-hanging fruit for plan sponsors who desire real savings. Second, cost-effectiveness research has shown that the individual activities that constitute contemporary DM programs are not cost saving except for heart failure. Targeting of specific patients and activity combinations based on risk, actionability, treatment and program effectiveness, and costs will be necessary to deliver a cost-saving DM program, combined with an outreach model that brings vendors closer to the patient and physician. Barriers to this evidence-driven approach include resources required, marketability, and business model disruption.


Conclusions: After a decade of market experimentation with limited success, new thinking is called for in the design of DM programs. A program design that is based on a cost-effectiveness approach, combined with greater program efficacy, will allow for the development of DM programs that are cost saving.

(Am J Manag Care. 2011;17(1):e10-e16)

Plan sponsors continue to search for new disease management (DM) models that can deliver real cost savings. Accordingly, it is of utmost importance to understand why the current commercial telephone-based DM model does not provide savings and how DM can be retooled based on the best available evidence.


  • Research shows that transitional care models represent low-hanging fruit for plan sponsors who desire short-term cost savings.


  • Evidence also shows that cost-effectiveness-based DM design that considers risk, actionability, treatment and program effectiveness, and all relevant costs can identify the patient and treatment combinations that have real potential for shorter-term cost savings.
Disease management (DM) emerged in the mid-1990s as a solution that offered better quality and lower costs. Enthusiasm for the concept was widespread given its intuitive appeal and positive results from recent studies1-4 of patients with heart failure. However, more recent research has not found savings from telephonebased nurse-led DM models,5-8 and the market is uncertain as to why these programs are not generating the savings that were much anticipated at their inception. Review of the literature in DM and   other disciplines provides guidance for future design. The objectives of this article are to discuss those insights, to suggest strategies for retooling the DM model to deliver greater value, and to highlight lessons learned from the commercial DM experience.


The early studies9,10 that helped stimulate interest in DM found that better management of patients with heart failure improved quality, reduced rehospitalizations, and sometimes saved money. Although these studies were generally well-constructed randomized controlled trials and showed promise for care management, they actually used care models that look quite different from today’s commercial DM (Table 1).11 They were typically conducted in academic research hospitals, targeted patients hospitalized for heart failure, and focused on inpatient and postdischarge follow-up. Patients usually lived in the same geographic region as the multidisciplinary team, allowing for face-to-face interaction after  discharge. This approach, often referred to as a transitional care (TC) model, is in stark contrast to the commercial DM model that exists in the marketplace today, which typically includes not just patients with heart failure but also those with diabetes mellitus, asthma, chronic obstructive pulmonary disease, and coronary artery disease (CAD). To be eligible,  patients can have prior inpatient visits or just outpatient visits. Intervention begins several months after identification because of the lag in medical claims reporting. Interventions are conducted primarily via telephone by a nurse who rarely has an established relationship with the patient or physician.

In contrasting the 2 models, it is easy to infer why the TC model has shown greater effectiveness.9,10,12 Transitional care targets fewer patients with greater risk for future hospitalization, uses a more intensive multidisciplinary and relationship-driven care model, and intervenes at a time of actionability. Although this distinction was noted by the Congressional Budget Office13 in its 2004 review of the DM literature, the important differences between the models generally have been overlooked. Even the Medicare Coordinated Care Demonstration did not incorporate the relevant features of the TC model but rather implemented a model that more closely mirrored the commercial DM vendors. Researchers questioned whether the Medicare Coordinated Care Demonstration would show cost savings given the notable differences, a concern that ultimately materialized.11 Although some contracts require DM vendors to embed TC in their offering,14 the key elements of TC effectiveness (ie, established relationship, intervention at or before discharge, some face-to-face contact, multidisciplinary team) are typically not a component of the commercial DM models.15

Despite evidence of cost savings, the TC model ironically has not met with the same commercial success as DM. Within the United States, 13 of 15 original TC programs for heart failure were discontinued primarily because of financial constraints, as many had received federal grant funding.11 Broader uptake has been limited primarily by the lack of financial incentives. Until health reform, hospitals have not had an incentive to reduce readmissions, and employers perhaps have believed that their DM or health plan vendor was successfully addressing this gap. Experts have recognized thevalue of TC,16 and as plan sponsors become more aware of the value, it will be important that they look for programs that possess the critical elements for real savings such as the partnership programs established by researchers at the University of Pennsylvania, Philadelphia, who have led  multiple successful randomized controlled trials of TC.17 It remains to be seen whether commercial DM companies can also develop the necessary multidisciplinary networks, rapid response processes, and more intensive care models.


While mistaken identity with the TC model at least partially explains the enthusiasm of the marketplace for DM, it does not explain why the current commercial DM model lacks strong evidence of savings. The answer to this question lies partly in the myriad of cost-effectiveness assessments that have been conducted on chronic disease treatment over the last 30 years. In a review of the literature, Cohen et al18 reportedthat less than 20% of preventive measures or treatments for chronic conditions are cost saving, even for a 30-year time horizon. Kahn et al19 found that aggressive implementation of nationally recommended medical activities would increase costs over a 30-year period for all activities except smoking cessation.

Looking more specifically at the individual components of DM programs, the evidence is equally compelling. Diabetes programs typically identify blood glucose control, medication use and adherence, and regular foot, eye, and microalbuminuria examinations as key goals. On an individual basis, none of these activities are cost saving, even over a 30-year period (Table 2).19-32 Disease management for CAD typically has the following 4 primary aims: diet modification, increased exercise, use of b-blockers, and use of cholesterol- lowering medications. Research has shown that use of these medications does not generate shorter-term cost savings when the medication costs are included.19,23 However, the cost-effectiveness profile of statins is moving closer to a net savings as more patients take advantage of the $4 generic programs offered by many retail pharmacies. Improved diet and exercise for patients with CAD have been shown to reduce recurrent myocardial infarctions, but the few formal cost-effectiveness analyses have not found cost savings.24,25 It is important to keep in mind that lifestyle changes for CAD are difficult to globally assess for cost-effectiveness because the program costs are driven by how much the lifestyle change costs (eg, food changes, gym membership) and by who is paying the bill. However, program fees alone are likely to exceed current commercial DM program fees because effective lifestyle programs are necessarily intensive.

Three hallmarks of asthma DM are improved use of controller medications, symptom monitoring, and reduction of triggers. Use of anti-inflammatory or controller medications reduces emergency department visits and hospitalizations but is not cost saving because of the significantly increased drug cost.26 The cost-saving potential is unclear for asthma education about triggers and symptom monitoring for a commercial DM program, as most investigations have been conducted among low-income pediatric populations, involved significant in-person education, and have not included the full range of abprogram costs (eg, peak flow meters).27,28 The only chronic condition for which research has demonstrated a clear opportunity for shorter-term savings is heart failure. Use of angiotensin-converting enzyme inhibitors and b-blockers is cost saving,29,30 and daily weight and blood pressure monitoring have been shown to be cost saving.31 However, the effective programs have provided structured monitoring rather than “as needed” monitoring and have collaborated with patients’ physicians to effectively respond to notifications, 2 key distinctions from many commercial DM programs. In fact, a recent evaluation of an electronic

home-monitoring system did not show clinical effect or savings.33 The authors acknowledged that participating physicians may have lacked the necessary resources and work flow changes to handle patient information provided by the monitoring system. Finally, a costeffectiveness analysis of moderate exercise training for heart failure has been conducted, but the program was not cost saving once exercise program costs and lost wages were included.32 However, similar to CAD, the cost savings depend on the cost of the exercise program and who is paying. The potential for savings exists, as moderate exercise can reduce the risk of hospitalization for heart failure by two-thirds.32

In summary, at the level of the individual program activity, savings have not been shown for the treatment of these chronic conditions other than heart failure. Accordingly, one should not necessarily expect to see cost savings for the program as a whole unless one believes that DM can independently improve the outcomes of patients with chronic disease without affecting the key clinical goals that have been outlined previously. Therefore, it is important to keep in mind that for pharmaceuticals in particular cost-effectiveness is likely to improve over time as more patients use generic alternatives and as generic prices continue to fall. Because of difficulty in demonstrating savings, some vendors have expanded the range of potential cost savings to include disability, workers’ compensation, program absenteeism, and worker productivity in an effort to generate a better savings value proposition. The success of these efforts remains to be seen. While another alternative would be to withdraw the expectation for savings from DM and to measure its success primarily through quality improvement, this seems an unlikely outcome in today’s economic climate.


Health reform certainly affords opportunity for wellness and chronic care management initiatives in commercial, Medicare, and Medicaid populations given its emphasis on prevention and incentives to promote chronic care management in multiple settings and populations. However, this and other research points to 4 important lessons that have been learned from the commercial DM market experience, which have implications not only for future DM programs but also for other population health management programs. These insights are discussed in the subsections that follow.

Targeting Patients and Treatments Provides a Pathway for Savings

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