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Supplements New Horizons in the Diagnosis and Treatment of Hereditary Angioedema: Overcoming Barriers to Management and Improving Patient Outcomes
Severity of Hereditary Angioedema, Prevalence, and Diagnostic Considerations
Jonathan A. Bernstein, MD
Current and Emerging Therapies to Prevent Hereditary Angioedema Attacks
William R. Lumry, MD
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Economic Burden Limiting Proper Healthcare Delivery, Management, and Improvement of Patient Outcomes
William J. Cardarelli, PharmD
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Economic Burden Limiting Proper Healthcare Delivery, Management, and Improvement of Patient Outcomes

William J. Cardarelli, PharmD
Although prompt and effective diagnosis and treatment of HAE are paramount to successful patient outcomes, the economics and costs of HAE and its therapy must also be addressed and managed by healthcare systems treating patients with this disorder. Costs of effective therapies must be balanced against the substantial costs of the disease, both in terms of direct medical costs and the impact of HAE on patient functioning and productivity. It is critical to consider PROs in all steps of HAE management and use validated questionnaires to assess patient preferences and status. This truly individualizes HAE management for every patient and potentially provides meaningful and interpretable measures of patient function and an assessment of the effectiveness of treatments and overall management.

Author affiliation: Director of Pharmacy Revenue & Supply, Atrius Health, Watertown, MA.
Funding source: This activity is supported by educational grants from CSL Behring and Shire.
Author disclosure: Dr Cardarelli has no relevant financial relationships with commercial interests to disclose.
Authorship information: Acquisition of data; analysis and interpretation of data; concept and design; critical revision of the manuscript for important intellectual content; drafting of the manuscript.
Address correspondence to: William_Cardarelli@vmed.org.
Dr Cardarelli gratefully acknowledges Elizabeth Paczolt, MD, for her contributions to the development of this article.
 
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