https://www.ajmc.com/journals/issue/2016/2016-vol22-n10/economic-value-of-pharmacist-led-medication-reconciliation-for-reducing-medication-errors-after-hospital-discharge
Economic Value of Pharmacist-Led Medication Reconciliation for Reducing Medication Errors After Hospital Discharge

Mehdi Najafzadeh, PhD; Jeffrey L. Schnipper, MD, MPH; William H. Shrank, MD, MSHS; Steven Kymes, PhD; Troyen A. Brennan, MD, JD, MPH; and Niteesh K. Choudhry, MD, PhD

Disruptions to, and changes in, a patient’s outpatient medication regimen occur frequently during hospitalization. This often results in discrepancies between drugs prescribed at discharge and the medications outpatient providers believe that patients should be on.1 Although the majority of such discrepancies do not have clinically important effects, their consequences can be profound. These events are defined as preventable adverse drug events (ADEs) because they are caused by medication discrepancies that could have been avoided. It is estimated that 2.4% to 4.1% of all hospital admissions are directly related to ADEs, and up to 69% of those ADEs are preventable.2-5 There are other circumstances in which the presence of a medication discrepancy has not yet resulted in an ADE, but may still be costly and/or may expose patients to the risks of additional testing or monitoring.6
 
Medication reconciliation by pharmacists at hospital discharge is a possible strategy to reduce medication discrepancies and subsequent ADEs. Several systematic reviews have found that medication reconciliation significantly reduces the risk of medication discrepancies.7-9 Despite this, not all studies evaluating the impact of medication reconciliation on health resource utilization (HRU) have found beneficial effects.10-19 These findings naturally raise questions about the economic value of this intervention and how the balance between the costs and benefits of the intervention could be optimized by, for example, selectively targeting high-risk patients.
 
Accordingly, we conducted a simulation-based cost-benefit analysis to estimate and compare the economic value of 3 strategies at hospital discharge: a) usual care (no intervention), b) nontargeted medication reconciliation for all patients, and c) targeted medication reconciliation that uses a screening tool to identify patients at high risk of postdischarge ADEs.
 
METHODS
Overall Approach

We developed a 2-part discrete-event simulation to prospectively model the sequence of events that occur within the 30 days after hospital discharge for a hypothetical cohort of patients who did, and did not, receive medication reconciliation. Consistent with the existing literature,6 we categorized medication discrepancies that were associated with harm as preventable ADEs and those not associated with harm as “potential” ADEs. We categorized both preventable ADEs and potential ADEs into those that were (or were potentially) life-threatening, serious, or significant. Nonsignificant events were considered, by definition, to not be a medication discrepancy.
 
Our model first estimated the incidence of medication discrepancies, preventable ADEs, their associated major HRUs (ie, emergency department [ED] visits and rehospitalizations), and costs among patients who did not undergo reconciliation (Figure 1 [A]). We then used the distribution of outcomes from the initial phase of the simulation to compare the impact of 3 interventions (Figure 1 [B]): a) a nontargeted pharmacist-led medication reconciliation intervention for all patients, b) a targeted pharmacist-led medication reconciliation intervention in which only patients at high risk of ADEs were intervened upon, and c) usual care (no intervention). Our modeling approach and structure have been explained in the eAppendix (eAppendices available at www.ajmc.com).
 
We used a cost-benefit analysis framework and conducted our analysis from the perspective of a hospital that was at risk for the added cost of any intervention and the savings from avoiding HRUs due to preventable ADEs. All costs were estimated in 2014 US dollars and, when necessary, unit costs were converted to 2014 prices using reported changes in the consumer price index.20 Considering the short period of analysis, no discount rate was applied. All simulations were developed using Arena version 12.00 (Rockwell Automation Technologies, Inc, Milwaukee, Wisconsin).
 
Patient Characteristics
The characteristics of the simulated cohort were assumed to be similar to populations in the studies that were the basis of our assumptions about event probabilities (Table 1).6 The model assumptions and event probabilities are based on data from the Pharmacist Intervention for Low Literacy in Cardiovascular Disease (PILL-CVD) study.6 In this randomized clinical trial, 851 patients hospitalized with acute coronary syndromes or acute decompensated heart failure were randomized to receive either a pharmacist-assisted intervention (ie, medication reconciliation, inpatient pharmacist counseling, low-literacy adherence aids, and individualized telephone follow-up) or usual care after hospital discharge. Similar to the trial population, the simulated cohort was assumed to have an average age of 60 years, have a median 14 years of education, and to be 60% male. We assumed that approximately 10% of the hypothetical cohort had inadequate health literacy and 8.7% had marginal, and that 11.5% had some level of cognitive impairment. We also assumed that approximately 60% of patients were hospitalized with acute coronary syndrome, 30% with acute heart failure, and 10% with both diagnoses.
 
Estimates of Medication Discrepancies and Subsequent Events
The incidences of medication discrepancies, preventable ADEs, and potential ADEs for patients not undergoing medication reconciliation were estimated using the distribution of observed events in the control arm of the PILL-CVD study.6 The distribution of events in the usual-care arm of PILL-CVD is summarized in eAppendix Figure A. In this study, 25 of the 125 (20%) patients with preventable ADEs were rehospitalized or visited an ED. Based on a case-by-case analysis of these patients by 1 study author (JLS), we determined that 24 of these ADEs were potentially amenable to medication reconciliation activities at the time of hospital discharge (as opposed to postdischarge activities, such as monitoring for ADEs).
 
The proportion of patients who had rehospitalizations, ED visits, or both events, was based on the observed rates in this trial6 and another large clinical trial.17 In the base-case analysis, we assumed that the intervention could reduce the risk of rehospitalization due to preventable ADEs, amenable to medication reconciliation, by 52% (ie, a relative risk of 0.48). This was based on an average effectiveness rate of medication reconciliation observed in 4 published studies of at least moderate methodological quality.11,14,15,21 The estimated effectiveness of the intervention may vary as a function of care setting, patient characteristics, composition of the healthcare team responsible for delivery of the intervention, and services that were bundled with medication reconciliation.7,8 As a result, we varied our assumptions of effectiveness extensively in the sensitivity analysis.
 
Patient Targeting
In order to estimate the impact of limiting medication reconciliation to high-risk patients (ie, those patients most likely to have a postdischarge ADE due to a medication discrepancy), we assumed that patients underwent screening with a tool that could predict, with some accuracy, the risk of ADEs based on the patient’s characteristics at the time of hospital discharge. A perfect screening tool could exactly discriminate patients with and without preventable ADEs, based on the information available at discharge, and would only assign the former to receive the intervention.
 
Given the sensitivity and specificity of this tool, we assigned patients into 4 categories: a) true positive, who would have had a preventable ADE and were assigned to receive the intervention; b) false positive, who would not have had a preventable ADE but were assigned to the intervention; c) false negative, who would have had a preventable ADE but were not assigned to receive the intervention; and d) true negative, who would not have had a preventable ADE and were not assigned to receive the intervention. We assumed that the effectiveness of targeted interventions was similar to that of the nontargeted strategy, in which medication reconciliation was offered to all patients.
 
Costs
Average cost per rehospitalization was based on recent estimates by the Agency for Health Research and Quality.22 The cost per ED visit was based on estimated charges in the same report, which were calculated by applying an estimated cost-to-charge ratio of 0.55.23,24 A 3% penalty rate was applied to all rehospitalization costs to reflect the current policies for readmission payment adjusted amount.25
 
Intervention costs were calculated using estimated average pharmacist time per reconciliation26 and average salary and benefit payments to pharmacists and pharmacy technicians.27 We assumed that pharmacy technicians, rather than pharmacists, conducted 50% of medication reconciliation-related tasks (eg, taking medication histories) in order to reduce the intervention cost. Pharmacists were assumed to supervise technicians and do some of the tasks, like patient counseling or order review, themselves. This assumption was varied in the sensitivity analysis. We also assumed that a medication history conducted by a pharmacy technician under a pharmacist’s supervision was as effective as that of one conducted by a pharmacist alone.28-30
 
Sensitivity Analysis
We performed extensive 1-way and 2-way sensitivity analyses to investigate the net benefit of medication reconciliation interventions under different assumptions for our model parameters, screening properties, and patients’ characteristics. A probabilistic sensitivity analysis also was performed to examine distribution of our point estimates, given uncertainty of the model parameters, by varying all of our model parameters simultaneously.31-33 We also reported credible intervals based on probabilistic sensitivity analyses that reflect uncertainty of simulated point estimates.
 
RESULTS
In a cohort of 10,000 patients not undergoing medication reconciliation, we estimated that 5090 would have at least 1 medication discrepancy within the first 30 days after hospital discharge. These medication errors would result in 3807 preventable ADEs and 5230 potential ADEs. Preventable ADEs would result in 421 rehospitalizations and 496 ED visits. Overall, the average cost of preventable ADEs was estimated to be $472 (95% credible interval [CI], $247-$778) per patient in the usual care strategy.
 
Medication Reconciliation for All Patients
Assuming that pharmacist-led medication reconciliation for all patients at hospital discharge could reduce medication errors by 52%, and therefore would reduce HRU due to preventable ADEs amenable to medication reconciliation by the same proportion, the number of rehospitalizations and ED visits related to preventable ADEs would be reduced to 199 and 215, respectively, with this strategy. This reduction in hospitalizations and ED visits would reduce the overall cost per patient to $266 (95% CI, $150-$423). This estimate includes the cost of medication reconciliation of approximately $39 per patient. Therefore, performing medication reconciliation for all patients at the time of hospital discharge would result in a significant net benefit of $206 (95% CI, $73-$373) per patient.
 
The impact of altering our assumptions about the effectiveness of medication reconciliation are presented in Table 2 and eAppendix Figure B. We found that the initial cost of the intervention would be more than offset by the savings from averted events as long as it reduced medication errors by at least 10%. The results of 1-way sensitivity analysis suggest that the net benefit is most sensitive to the effectiveness of intervention, the proportion of preventable ADEs that result in a rehospitalization or ED visit, and the average length of stay for patients who had an ADE-related rehospitalization (Figure 2).

The results of our probabilistic sensitivity analysis are presented in eAppendix Figure C. We found that the uncertainty around net benefit ranges between –$2 and $577 per patient, with 99% of the simulated trials resulting in a positive net benefit.
 
Medication Reconciliation for Targeted Patients
The net benefit from targeting medication reconciliation under our base-case assumptions of 70% sensitivity and 70% specificity was $146 savings per patient, which was not superior to the savings from a nontargeted approach ($206 per patient). The impact of alternating our assumptions about sensitivity and specificity of the screening tool are presented in Table 3 and eAppendix Figure D. We found that the net benefit could be as high as $232 per patient, if the specificity and sensitivity of a screening tool were 100%. The net benefit could exceed that which we obtained in the base-case analysis as long as the sensitivity and specificity of the screening tool were at least 90% and 70%, respectively. However, in general, improving the sensitivity of the screening tool has larger impact on net benefits than improving specificity. For example, a screening tool with 100% sensitivity resulted in a net benefit of $222 per patient even if the specificity was only 60%.
 
The added value of a targeted intervention increased as the effectiveness of the intervention decreased and the cost of intervention increased. For example, if medication reconciliation reduced the risk of medication discrepancy by 20% (rather than 52%) and is more expensive (eg, because it is performed by pharmacists rather than a combination of pharmacist technicians and pharmacists), then a targeted intervention is the preferred approach.
 
DISCUSSION
Although pharmacist-led medication reconciliation reduces medication errors that commonly occur after hospital discharge, its economic value has not been completely evaluated. We found that this intervention, when performed at the time of hospital discharge, reduced the cost of rehospitalizations and ED visits that resulted from medication discrepancies within 30 days after hospital discharge from $472 per patient to $266. This resulted in a net savings of $206 per patient, after accounting for the cost of the intervention. The magnitude of this savings could be increased if a screening tool, with very high sensitivity and modest specificity, was used to identify and target patients at higher risk of preventable postdischarge ADEs.
 
More than half of hospitalized patients are estimated to have 1 or more medication discrepancy after hospital discharge.6,8 ADEs resulting from these discrepancies result in the rehospitalization of approximately 4% of discharged patients.6 This highlights the opportunity for interventions that can prevent medication discrepancies to both improve quality and lower costs. Medication reconciliation at the time of hospital discharge involves a bundle of activities including patient counseling and communication with outpatient providers.
 
Although careful medication reconciliation at hospital discharge can potentially eliminate many discrepancies in discharge medication orders,7,8 it, not surprisingly, has a more limited effect on other types of medication errors that occur during the postdischarge period. For example, patient misunderstanding of their medication regimen could lead to additional discrepancies after discharge.10 Likely for this reason, reconciliation programs that include a telephone follow-up after discharge—along with other, more conventional features such as coordination with physicians, patient education, and transition coaching—have, in general, been more effective.17,34
 
Our results suggest that despite the use of relatively costly pharmacists and pharmacy technicians, the cost savings from avoided rehospitalizations would more than offset the cost of the intervention. This is consistent with the limited existing cost-effectiveness evidence.35,36 The value of medication reconciliation could be increased if it were preferentially used for individuals at the highest risk of ADEs. This is consistent with the fact that many of the most effective medication reconciliation interventions reported in the literature are those that were targeted interventions, rather than administered to all patients.18,19 Several studies have attempted to develop risk prediction models for hospital readmissions with acceptable accuracy.37,38 However, these models tend to predict risk of all rehospitalizations in the first 30 days after discharge and, therefore, are not necessarily calibrated to predict the risk of readmission specifically resulting from medication errors.1
 
The estimates of costs and benefits of medication reconciliation in our study assume that those paying for medication reconciliation interventions are the same ones that share the savings from reduced postdischarge HRUs. The extent to which this is true varies tremendously at present; however, it most certainly will increase dramatically in the near future. For example, in 2015, approximately 20% of Medicare payments are based on non–fee-for-service payment models. This share is expected to increase to 30% by 2016 and to 50% in 2018.39 These models included bundled payments, in which providers are at risk for the cost of any readmissions occurring in the 30-to-90-day period after discharge.
 
Similarly, accountable care organizations put providers at risk for the total cost of care of the populations they serve; these incentives have encouraged providers to target readmissions as an opportunity to improve care and reduce costs. Moreover, Medicare has introduced readmission penalties broadly, and these penalties have led to much greater focus on readmission rates. As a whole, these payment models are critical to creating the business case for hospitals to invest in interventions such as mediation reconciliation.

Factors other than the intervention cost might limit the implementation of medication reconciliation. Pharmacists or other healthcare professionals conducting this intervention must have access to accurate and timely information about inpatient and outpatient mediations. As such, the availability of electronic health records40 that can facilitate obtaining medication records from different points of care will directly affect the feasibility and success of medication reconciliation.41 Patient-specific barriers, such as lower education level and language and other communication barriers, could limit the successful implementation of medication reconciliation in some healthcare settings.
 
Limitations
Our study should be viewed in light of its limitations. Only a handful of studies have shown the direct impact of medication reconciliation interventions on postdischarge HRU. As a result, our model was based on a chain of events whereby medication discrepancies lead to postdischarge ADEs and HRU, and on studies that show reductions in these discrepancies and in some of the downstream events. Although each link in the chain can be supported by data, we acknowledge that estimates of effectiveness on patient outcomes may be inaccurate. It is reassuring, however, that our results were largely unchanged in the extensive sensitivity analyses we conducted. In addition, the studies we used to derive our base-case estimates were based on specific patient populations, and thus may not be generalizable to all other patient groups or care settings.
 
CONCLUSIONS
Our study suggests that a pharmacist-led medication reconciliation can be a cost-saving strategy compared with usual care. The net benefit of this intervention could be enhanced using a highly sensitive screening tool for patients at high risk for postdischarge ADEs. Future studies should more directly make the link between interventions and reductions in postdischarge healthcare utilization in order to increase the precision of cost-benefit estimates.
 
 
Acknowledgments
The authors would like to thank Sunil Kripalani, MD, MSc, and Kathryn Goggins, MPH, both of Vanderbilt University, for providing unpublished data from the PILL-CVD study that were crucial for developing the current analysis.
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