Induction Treatment Based on Pharmacogenomics May Address Racial Disparities in AML
Data from this new study suggest that tailoring induction therapy for acute myeloid leukemia (AML) based on cytarabine pharmacogenomic 10–single-nucleotide variant score could better treatment for these young patients, particularly those who are Black.
CHESS II: Hemophilia Severity Correlates With Economic Burden, Patient QOL
The data come from the observational Cost of Hemophilia in Europe: A Socioeconomic Survey II (CHESS II) study of 288 Spanish patients with hemophilia A and B, which showed certain differences between disease subtypes but overall similar trends in disease impact.
Proof-of-Concept Study Highlights Potential of Gene-Based Therapy for Timothy Disease
The proof-of-concept study showed that antisense oligonucleotides developed by the researchers successfully restored cellular development and brain cell function in patients with the disease characterized by multiorgan dysfunction.
Enhancing Outpatient Hemophilia Care May Improve Health Outcomes and Costs
Prospective data from patients attending a rural practice in West Virginia between 2016 and 2023 show that a quality improvement program that followed guideline recommendations and was tailored to specific patient needs reduced preventable bleeds and lowered costs.
Initiating BP Medication Linked to Higher Fall, Fracture Risks in Nursing Home Residents
Among over 60,000 nursing home residents who initiated antihypertensive medication, rates of excess fractures due to falls per 100 person-years were as high as 5 among certain patient groups, such as those with dementia and high blood pressure (BP).
Reducing Time Sitting Can Help Lower BP in Older Adults, Randomized Trial Finds
The randomized trial found that reducing sitting time over a 6-month period was association with reduced systolic blood pressure (BP) among a group of older patients with obesity and high rates of hypertension.
Study Suggests Walking 10K Steps Daily Improves QOL in Severe Hemophilia
Among a small group of patients with severe hemophilia, researchers found that getting in more than 10,000 steps each day was linked to significant improvements in perceived physical health and quality of life (QOL).