Emerging Agents and Clinical Perspectives in ER+/HER2- Metastatic Breast Cancer

EP: 1.Evolution of Endocrine Therapies in ER+/HER2– Metastatic Breast Cancer

EP: 2.Efficacy and Safety of Oral SERDs and Other Endocrine Therapies in ER+/HER2- Metastatic Breast Cancer

EP: 3.Elacestrant Usage in ER+/HER2- Metastatic Breast Cancer: Clinical Guidelines and Patient Profiles

EP: 4.ESR1 Mutation Testing and Precision Medicine in Patients With ER+/HER2- Metastatic Breast Cancer

EP: 5.Elacestrant in Later-Line Treatment of ER+/HER2– Metastatic Breast Cancer

EP: 6.Elacestrant: Treatment Considerations, Including Dosing and Compliance

EP: 7.Elacestrant: Adverse Effects and Their Management, and Impact of Treatment on Quality of Life

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EP: 8.Emerging Agents and Clinical Perspectives in ER+/HER2- Metastatic Breast Cancer

EP: 9.Overview of ESR1 Mutations in ER+/HER2- Metastatic Breast Cancer

EP: 10.Best Practices for ESR1 Mutation Testing in Patients With Breast Cancer

EP: 11.The Role of Oral SERDs in ER+/HER2- Metastatic Breast Cancer

EP: 12.Oral SERDs in Development for ER+/HER2- Metastatic Breast Cancer

EP: 13.Research Landscape: Endocrine Therapies for ER+/HER2- Metastatic Breast Cancer

This is a video synopsis/summary of a Peer Exchange featuring Mabel Mardones, MD; Rena Callahan, MD; William Gradishar, MD; and Gregory Vidal, MD, PhD.

Mardones addresses strategies to reduce barriers to medication access, with Callahan emphasizing the role of clinical pathways in streamlining ESR1 mutation testing documentation. Vidal discusses oral selective estrogen receptor degraders (SERDs) in development, highlighting differences in toxicity profiles among agents and expressing anticipation for these options in clinical practice. Gradishar explores the evolving landscape of new agents. The discussion emphasizes the need for differentiation and efficacy data among emerging drugs, which promise an exciting era with expanded treatment options for patients with estrogen receptor–positive (ER+)/HER2-negative (HER2–) breast cancer. Concluding the peer exchange, each expert shares their final thoughts, celebrating the current and upcoming advancements in ER+/HER– breast cancer therapeutics, focusing on their efficacy, tolerability, and potential to improve patient outcomes and quality of life. Stay informed about the evolving landscape of breast cancer treatments and explore the promising future of tailored therapies.

Video synopsis is AI-generated and reviewed by AJMC^® editorial staff.