Timely Detection: Incidence and Prevalence of Ph+ ALL

EP: 1.Overview of Characteristics Unique to Ph+ ALL

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EP: 2.Timely Detection: Incidence and Prevalence of Ph+ ALL

EP: 3.Supporting Ph+ ALL Patient: Emotional Challenges and Quality of Life

EP: 4.Screening and Diagnosing of Ph+ ALL in Adults

EP: 5.Diagnosis and Treatment Timeline: Different Phases of Ph+ ALL Management

EP: 6.Current Front-Line Targeted Treatments in Ph+ ALL

EP: 7.Prior Authorization and Access to Targeted Treatment for Ph+ ALL Patients

EP: 8.PhALLCON Trial: Efficacy and Safety of Ponatinib in Ph+ ALL Patients

EP: 9.Value-Based Care Models Optimizing Ph+ ALL Patient Care

EP: 10.Unmet Needs in Screening, Diagnosis, and Management of Ph+ ALL

EP: 11.Disparities in Access to Care for Ph+ ALL patients

EP: 12.The Future of Ph+ ALL Treatments

EP: 13.Concluding Thoughts on Ph+ ALL Treatment

The following is a video synopsis/summary of a Peer Exchange involving Ryan Haumschild, PharmD, MS, MBA, CPEL; Jonathon Abbas, MD; Vivian Tambe Tar, PharmD, MBA; Elias Jabbour, MD; and James McCloskey, MD.

The discussants characterize Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) as a rare leukemia, with an incidence of approximately 6000 cases per year in the United States. Ebot-Tar notes that in a health plan with over 1 million members, the incidence would be approximately 4 to 5 cases per million members. The incidence increases with age. McCloskey emphasizes the importance of timely detection and treatment for optimal outcomes. Targeted therapies are crucial.

Haumschild asks about ensuring timely access to appropriate therapies through payer policies. Ebot-Tar discusses the need to balance cost considerations with ensuring access, using management strategies judiciously to avoid barriers to needed care. Jabbour advocates for optimal upfront therapy to provide the best chance for response and long-term value. The group agrees that durable initial response is ideal to improve overall survival, which drops with later lines of therapy, and that payers should understand the clinical and economic rationale for this approach.

Video synopsis is AI-generated and reviewed by AJMC editorial staff.