- Center on Health Equity and Access
- Clinical
- Health Care Cost
- Health Care Delivery
- Insurance
- Policy
- Technology
- Value-Based Care
Mutation May Be Associated With Resistance to NSCLC Immunotherapy
A specific mutation has been linked with acquired resistance in immunotherapy drugs used to treat non–small lung cancer (NSCLC).
A specific mutation has been linked with acquired resistance in immunotherapy drugs used to treat non—small lung cancer (NSCLC).
Researchers led by cancer biologist Katerina Politi, PhD, associate professor in the Yale Department of Pathology and Medical Oncology, have discovered that a mutation in a viral protein called B2M prevents the immune activation needed for immunotherapy agents to function. The discovery of this new resistance mechanism explains why some patients develop resistance later on in treatment and may also steer the evolution of future NSCLC drug development.1
For patients with NSCLC who are not candidates for other targeted therapies, immunotherapy is considered to be a viable treatment alternative. Immunotherapy drugs that have earned FDA approval to treat NSCLC include breakthrough therapies like nivolumab and pembrolizumab, as well as the most recent agent, atezolizumab.
Frameworks for Advancing Health Equity: Urban Health Outreach
May 9th 2024In the series debut episode of "Frameworks for Advancing Health Equity," Mary Sligh, CRNP, and Chelsea Chappars, of Allegheny Health Network, explain how the Urban Health Outreach program aims to improve health equity for individuals experiencing homelessness.
Listen
Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
Listen
