March 7th 2024
Differences in bone density and FRAX fracture risk scores among Black and Asian women yield greater discordance in fracture risk estimation compared with White women.
Genetics Study Finds Bone Mineral Density, Not Vitamin D, Significantly Affects Fracture Risk
September 14th 2018A study investigating the genetic determinants of fracture risk identified 15 genetic determinants of fracture, which also influenced bone mineral density. Among the clinical risk factors considered, only bone mineral density demonstrated a major causal effect on fracture, while genetic predisposition to lower levels of vitamin D and estimated calcium intake from dairy were not associated with fracture risk, according to the results.
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Assessing Denosumab's Effects on BMD in Women With Breast Cancer
September 7th 2018Twice-yearly treatment with denosumab, a fully human monoclonal antibody, may be associated with increased bone mineral density (BMD) among patients who receive adjuvant aromatase inhibitors (AIs) therapy, according to a recent study.
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Study Assesses Correlations Between BMD, Serum Levels of Bone Turnover Markers
August 23rd 2018The diagnosis of osteoporosis is typically determined by bone mass density (BMD); however, bone turnover markers (BTMs) can provide information involving the bone remodeling process. A recent study found that BMD correlates negatively with BTM and positively with estradiol (E2) and magnesium (Mg(2+)) levels, and tartrate-resistant acid phosphatase-5b (TRAP-5b) demonstrates a specificity in identifying patients with postmenopausal osteoporosis.
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What Are the Effects of Type 2 Diabetes Treatment on Bone Turnover Markers?
August 16th 2018A recent study investigated whether different insulin regimens, such as metformin and rosiglitazone, influence bone metabolism in individuals with type 2 diabetes, who often have an increased risk of fractures.
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Study Suggests Improved Adherence to Osteoporosis Drugs May Cut Healthcare Costs
August 10th 2018The results of a recent population-based study from Korea identified fractures, age, and medication adherence as factors that affect osteoporosis-related healthcare costs, and said improved medication adherence could save approximately $5 million of osteoporosis-related healthcare costs annually.
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Soy Protein Might Increase Bone Strength in Women, Animal Study Suggests
August 8th 2018Soy protein improved the tibia bones in female rats with poor levels of physical fitness, regardless of ovarian hormone status, according to a recent study, and researchers said the findings could have dietary implications for menopausal women.
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Report Finds Denosumab Effective for Patient With NF1 Mutation, Osteoporosis
August 2nd 2018The research and therapeutic options are limited for skeletal abnormalities found in neurofibromatosis type 1 (NF1)—a haploinsufficient and multisystemic disease caused by inherited or sporadic mutations in the NF1 gene. However, denosumab may be an effective treatment option for osteoporosis in patients with NF1, according to a recent case report.
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Study Investigates Link Between Excess Mortality and Fragility Fractures
July 28th 2018There is minimal previous research involving long-term excess mortality following fragility non-hip fractures. A nationwide registry-based follow-up study aimed to determine which fracture was associated with excess mortality and how long the postfracture excess mortality continued.
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Researcher Says Genetic Screenings Can Discover Osteoporosis Risk
July 26th 2018The largest genomewide association studies ever completed for osteoporosis identified 899 loci, or regions, in the human genome associated with low bone mineral density, 613 of which have not yet been discovered. The Stanford University School of Medicine researcher who made the finding said that widespread genetic screenings could predict a person's future risk of osteoporosis and bone fracture.
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Rate of Osteoporosis Drug Treatment to Prevent Recurrent Fractures Dropping
July 20th 2018A study of more than 97,000 elderly patients with hip fracture found they were not often prescribed osteoporosis medications in an effort to prevent future fractures, and in fact, the rates declined over 12 years—a finding that surprised researchers.
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