Published Online: February 06, 2012
Dramatically condensing radiation treatment for early prostate cancer into just 5 fractions produces good results without much toxicity, an early-phase study suggested. The hypofractionated schedule resulted in 99% biochemical and pathological control and only 1% experienced mild radiation side effects at 3 years, D. Andrew Loblaw, MD, of Sunnybrook Health Sciences Center in Toronto, and colleagues found.
Acute toxicity topped out at 1 case of grade 3 genitourinary problems among 83 patients treated, they reported here at the Genitourinary Cancers Symposium.
"That's a huge deal. Normal dosing is 40 to 45 fractions," Nicholas J. Vogelzang, MD, medical director of the developmental therapeutics committee of US Oncology, told MedPage Today
. "Using accelerated hypofractionation, you can get what appear to be identical outcomes."
Not only would the once-weekly schedule with a total of only 5 radiation treatments used in the study be more convenient for patients, but it would likely substantially drop overall radiation costs, Vogelzang predicted.
Read more at: http://www.medpagetoday.com/MeetingCoverage/MGUCS/31020
Source: MedPage Today