- Center on Health Equity and Access
- Clinical
- Health Care Cost
- Health Care Delivery
- Insurance
- Policy
- Technology
- Value-Based Care
Anti-CD20 Antibody Improves Lenalidomide Performance in CLL
From 20 months to upto 5 years, blocking CD20 significantly improved OS in CLL patients.
Patients with relapsed/refractory chronic lymphocytic leukemia (CLL) lived twice as long when treated with lenalidomide (Revlimid) plus an anti-CD20 antibody compared with lenalidomide alone, a series of clinical trials showed.
Median overall survival increased from 20 months with lenalidomide alone to as much as much as 5 years with the addition of either of two monoclonal antibodies. As compared with lenalidomide alone, the combination improved response rate, time to treatment failure (TTF), and overall survival, Philip A. Thompson, MD, of the University of Texas MD Anderson Cancer Center in Houston, reported here at the European Hematology Association meeting.
"We observed similar results with lenalidomide and either ofatumumab (Arzerra) or rituximab (Rituxan)," said Thompson. "A subgroup of patients has highly durable remissions, even after cessation of treatment. Our focus for the future is on combining lenalidomide with more potent CD20 monoclonal antibodies and combining lenalidomide and a CD20 monoclonal antibody with other novel therapies.
Read the report here: http://bit.ly/1kSIKDQ
Source: Medpage Today
Oncology Onward: A Conversation With Penn Medicine's Dr Justin Bekelman
December 19th 2023Justin Bekelman, MD, director of the Penn Center for Cancer Care Innovation, sat with our hosts Emeline Aviki, MD, MBA, and Stephen Schleicher, MD, MBA, for our final episode of 2023 to discuss the importance of collaboration between academic medicine and community oncology and testing innovative cancer care delivery in these settings.
Listen
