Currently Viewing:
Currently Reading
Surgical Site Infections Common After Gastrointestinal Surgeries Worldwide
February 18, 2018 – Kaitlynn Ely
USPSTF Recommends Against Screening for Ovarian Cancer in Asymptomatic Women
February 18, 2018 – Jaime Rosenberg
Study Finds Merkel Cell Carcinoma Incidence Has Increased Since 2000
February 17, 2018 – Kaitlynn Ely
New ECPR Protocol Shows Increase in Survival of Some Cardiac Arrest Patients
February 17, 2018 – Samantha DiGrande
Anthem Changes to ED Payment Policy Leaves Some Unsatisfied
February 16, 2018 – Allison Inserro
5 Things Being Discussed and Addressed in Healthcare Spending
February 16, 2018 – Jaime Rosenberg
This Week in Managed Care: February 16, 2018
February 16, 2018
AJMC® in the Press, February 16, 2018
February 16, 2018 – AJMC Staff
Survey Identifies Barriers to Achieving Value-Based Care Models
February 16, 2018 – Kaitlynn Ely

Studies Find Association Between Vectra DA Scores and Joint Damage Progression in RA Patients

Alison Rodriguez
New data has demonstrated an association between high Vectra DA scores and an increased risk of joint damage progression in patients with rheumatoid arthritis.
On Wednesday at the European League Against Rheumatism (EULAR) meeting in Madrid, Spain, Crescendo Bioscience announced new results from a meta-analysis of several clinical studies. The new data demonstrated an association between high Vectra DA scores and an increased risk of joint damage progression in patients with rheumatoid arthritis (RA).

Crescendo Bioscience researchers analyzed 800 RA patients, among 6 studies, that received DMARDs alone or in combination with adalimumab, infliximab or abatacept. The analysis aimed to evaluate the connection between Vectra DA scores, a quantified number from a multi-biomarker blood test, and radiographic progression (RP) risk.

In the individual studies, there was an association between high Vectra DA scores (>44) and RP frequency. The analysis, with all studies considered, indicated that patients with high Vectra DA scores were 3.6 to 9.5 times more likely to suffer from RP than those with low Vectra DA scores.

“In this meta-analysis, the Vectra DA test has demonstrated the superior ability to predict joint damage compared with traditional measures such as DAS28-CRP or CRP, making Vectra DA an important tool in the management of patients with RA,” Elena Hitraya, MD, PhD, chief medical officer at Crescendo Bioscience, said in a statement. “Importantly, Vectra DA also demonstrated clinical value by identifying patients with little or no risk of RP. We believe combining the Vectra DA score with conventional clinical measures will enable physicians to individualize treatment plans for their patients, improve outcomes and reduce the burden of future healthcare costs associated with this disabling disease.”

The Vectra DA scoring system has been proven useful with more than 3000 patients among 35 studies and can be used to help physicians choose proper treatments for their patients with RA.

“Importantly, this analysis confirms the consistency and robustness of the previous findings,” concluded Hitraya. “This new information advances the understanding of the role of molecule biomarkers in RA and can help to facilitate the discussion on the role of biomarkers in RA treatment guidance.”

Copyright AJMC 2006-2018 Clinical Care Targeted Communications Group, LLC. All Rights Reserved.
Welcome the the new and improved, the premier managed market network. Tell us about yourself so that we can serve you better.
Sign Up

Sign In

Not a member? Sign up now!