Currently Viewing:
Newsroom
Currently Reading
Pfizer Announces Phase 3 Trial for Atopic Dermatitis Treatment
December 15, 2017 – Samantha DiGrande
Majority of Women With Breast Cancer Surgery Did Not Feel Fully Informed of Treatment Options
December 15, 2017 – Jaime Rosenberg
AJMC® in the Press, December 15, 2017
December 15, 2017 – AJMC Staff
What We're Reading: Medicare Lab Testing; CHIP Deadline; AMA Expands Diabetes Efforts
December 15, 2017 – AJMC Staff
5 Key Takeaways From ASH 2017
December 15, 2017 – Surabhi Dangi-Garimella, PhD
This Week in Managed Care: December 15, 2017
December 15, 2017
What We're Reading: Medical Device Tax; Marijuana and Vaping; Birth Control Without Prescriptions
December 14, 2017 – AJMC Staff
Study Finds Breathing Retraining Associated With Quality of Life Improvement for Patients With Asthma
December 14, 2017 – Laura Joszt
Rain and Pain Not Related, Harvard Researchers Say
December 13, 2017 – Allison Inserro

Study: Linoleic Acid Is Beneficial for Prevention of Type 2 Diabetes

Jaime Rosenberg
With little research on the effects of omega-6 polyunsaturated acids in the prevention of type 2 diabetes (T2D), the study focused on the link between linoleic acid and arachidonic acid biomarkers with incident T2D.
Findings from a new study show that linoleic acid has long-term benefits for the prevention of type 2 diabetes (T2D) and that arachidonic acid is not harmful.

The study, published in The Lancet, focused on assessing the association of both linoleic acid and arachidonic acid biomarkers with incident T2D, using data from 20 cohort studies from 10 countries.

“The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAS) remain contentious, and little evidence is available regarding their potentional role in primary prevention of type 2 diabetes,” wrote the authors.

The effects of linoleic acid on an individual’s health is often disputed. While most major guidelines recommend that 5%-10% of energy is attributed to linoleic acid, some researchers have said it might be harmful because it competes with omega-3 PUFA or because its metabolite arachidonic acid might have harmful effects.

Results of the study showed that biomarker levels of linoleic acid were inversely linked with incident T2D, with high linoleic acid levels being associated with a 43% lower risk of T2D. The association was not influenced by age, body-mass index, sex, race, omega-3 PUFA levels, aspirin use, or variation in genes encoding FADS. Further, levels of arachidonic acid biomarkers were not associated with T2D.

Past studies have found that incorporating linoleic acid into phospholipids alters membrane fluidity and might modulate insulin receptor activity. In a meta-analysis of 102 randomized controlled feeding trials, predominantly linoleic acid dietary PUFAs improved glycaemia, insulin resistance, and insulin secretion. Other randomized controlled trials found that linoleic acid–rich vegetable oil reduced markers of inflammation, visceral fat deposition, and hepatic steatosis.

The current study expanded upon these findings. Knowing that dietary linoleic acid intake correlates with levels of circulating and tissue linoleic acid, the authors were able to provide evidence that linoleic acid might have long-term benefits for preventing the onset of type 2 diabetes using their biomarker-based findings. This supports clinical recommendations to increase dietary intake of linoleic acid–rich vegetables.

“The prevalence of type 2 diabetes is escalating rapidly around the world, so identification of dietary and other modifiable risk factors for the prevention of the disease is of clinical, scientific, and public health importance,” concluded the authors.

Even with the known benefits of PUFAs for blood cholesterol levels and glucose-insulin homeostasis, some scientists insist that omega-6 PUFA has negative effects for health. A common theory is that the conversion of linoleic acid to arachidonic acid is considered pro-inflammatory and potentially harmful for glucose metabolism, weight regulation, and eating behavior. 

 
Copyright AJMC 2006-2017 Clinical Care Targeted Communications Group, LLC. All Rights Reserved.
x
Welcome the the new and improved AJMC.com, the premier managed market network. Tell us about yourself so that we can serve you better.
Sign Up
×

Sign In

Not a member? Sign up now!