Currently Viewing:
American Diabetes Association (ADA) 2017
Dr Alan Carter on Biosimilars in the Insulin Market
July 27, 2017
Dr Eda Cengiz on New Technologies in Diabetes Management
July 26, 2017
Robby Booth of Glytec Discusses the Importance of Data-Sharing Capabilities
July 24, 2017
Dr Andrew Rhinehart: Improving Intermediate Outcomes in Diabetes Research
July 20, 2017
WellDoc Data Offer Promise for Integrating Diabetes Data Into Workflow
July 17, 2017
Dr Alan Carter on the Steps to Managing Rising Insulin Costs
July 17, 2017
Dr Eda Cengiz Discusses the Future of Diabetes Management
July 13, 2017
Nina Brown-Ashford: DPP Will Improve Care and Costs for Prediabetes Patients
July 06, 2017
Dr Alan Carter on Increasing Insulin Costs
July 04, 2017
Dr William Polonsky on Diabetes Patients' Treatment Satisfaction and Insulin Adherence
June 29, 2017
Dr Eda Cengiz on Improvements in Closed-Loop Systems
June 26, 2017
With Glytec, Hospital Moves to Basal-Bolus Insulin, Saves $9.7 Million
June 21, 2017
Raymie McFarland Discusses Findings From Glytec's Basal-Bolus Insulin Study
June 21, 2017
Sanofi Presents New Results for Insulin GLP-1 Combo Soliqua
June 13, 2017
Currently Reading
Dr Bruce Neal Discusses Canagliflozin's Potential for Heart Failure Prevention
June 13, 2017
CGM "Debate" Finds Benefits, Barriers to Uptake for Type 2 Diabetes
June 12, 2017
CANVAS Finds Lower Risk of CV Events for Invokana
June 12, 2017
Phase 3 Results Show Lower A1C for Ertugliflozin, Combined With Metformin and With Sitagliptin
June 12, 2017
Heart Failure Needs More Attention in Diabetes Drug Trials, Expert Says
June 11, 2017

Dr Bruce Neal Discusses Canagliflozin's Potential for Heart Failure Prevention

The CANVAS study’s outcomes were “a positive first step” in proving that canagliflozin can be used for the primary prevention of heart failure in patients with diabetes, but more evidence is needed, according to the study’s lead author, Bruce Neal, MB, ChB, PhD, of the George Institute for Global Health at UNSW Sydney, who presented the findings at the 77th Scientific Sessions of the American Diabetes Association’s in San Diego, California.


The CANVAS study’s outcomes were “a positive first step” in proving that canagliflozin can be used for the primary prevention of heart failure in patients with diabetes, but more evidence is needed, according to the study’s lead author, Bruce Neal, MB, ChB, PhD, of the George Institute for Global Health at UNSW Sydney, who presented the findings at the 77th Scientific Sessions of the American Diabetes Association’s in San Diego, California.

Transcript (slightly modified)

How was the CANVAS program different from other SGLT2 inhibitor trials?

It’s hard to directly compare the CANVAS program with the other SGLT2 programs because we’ve got a slightly different patient subset. For example, two-thirds of our patients were patients with existing vascular disease, but one-third were primary prevention patients, so that’s a new patient subset that’s being investigated here, but that makes it difficult to directly compare it to the others.

I think the top line is that, if you look at the CANVAS program compared to the Jardiance program, for that primary cardiovascular outcome the findings are almost identical. Once you start to get down into looking at more specific outcomes with smaller numbers of events, it’s really much harder to make robust comparisons.

What do the CANVAS results indicate about primary prevention of heart failure with canagliflozin?

The program results are interesting, because we did have this one-third of participants who were primary prevention. Of course, we don’t have enough events to say this was independently significant in primary prevention because we didn’t power it to do that. What we can do is look to see, was there any evidence that it was different in the primary prevention to the secondary prevention, and we certainly don’t see any evidence of that. It’s a positive first step, but we really want some more data.

In terms of the heart failure piece, I think there’s a lot of interest in this class for the management of heart failure, because it clearly has a volume offloading effect, and that’s probably a big part of why we see these early benefits with the drug. I think patients who have got diabetes and are perceived to be at risk of heart failure are going to be really strong candidates for canagliflozin and other SGLT2 inhibitors.

 
Copyright AJMC 2006-2017 Clinical Care Targeted Communications Group, LLC. All Rights Reserved.
x
Welcome the the new and improved AJMC.com, the premier managed market network. Tell us about yourself so that we can serve you better.
Sign Up
×

Sign In

Not a member? Sign up now!