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Literature: Germline BRCA Mutations Increase Susceptibility to Salivary Gland Cancer
The study, published online in JAMA Otolaryngology - Head & Neck Surgery, found a significant increase in the rate of head and neck cancers in individuals carrying a BRCA mutation.
5754 individuals from 187 pedigrees were included in the cohort. Previous research has identified a link between salivary gland cancer and breast cancer, which formed the basis of the current study.
From the 5754 individual cohort, 2 parotid gland cancers, 2 salivary gland cancers not otherwise specified, and 1 adenoid cystic carcinoma were identified.
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One of these cancers likely did not segregate with the mutation, and another individual tested negative for the mutation, resulting in a rate of 3 of 5754 (0.052%). The observed rate of 3 of 5754 cases (0.052%) of head and neck cancers in -positive probands and likely carriers is significantly higher than the background incidence rate of 3 of 100,000 (0.003%) per year ( < .001).
The Clinical Cancer Genetics Program at The Ohio State University Wexner Medical Center. A total of
In this retrospective review, the authors evaluated several pedigrees of patients who were diagnosed with breast cancer in
Link to the journal article: http://bit.ly/1BAqxUz
Link to Rebecca Nagy's (senior author on the paper) participation in AJMC's panel discussion on genetic counseling: http://bit.ly/1vjffSr
Oncology Onward: A Conversation With Penn Medicine's Dr Justin Bekelman
December 19th 2023Justin Bekelman, MD, director of the Penn Center for Cancer Care Innovation, sat with our hosts Emeline Aviki, MD, MBA, and Stephen Schleicher, MD, MBA, for our final episode of 2023 to discuss the importance of collaboration between academic medicine and community oncology and testing innovative cancer care delivery in these settings.
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