Currently Viewing:
Newsroom
Currently Reading
What's the Magic Payment Mix for Medicare Primary Care Providers?
December 11, 2017 – Allison Inserro
Sanofi's Insulin Lispro Follow-On, Admelog, Wins FDA Approval
December 11, 2017 – Mary Caffrey
The Past, Present, and Future of HIV Funding
December 11, 2017 – Jaime Rosenberg
What We're Reading: Harsh Flu Season; Potential Hospital Giants Merger; ACA Sign-Up Deadline
December 11, 2017 – AJMC Staff
ICER Seeking Public Comment About Migraine, Plaque Psoriasis Treatments
December 11, 2017 – Allison Inserro
ADA 2018 Standards Address Drugs With CV Benefits, Hold Firm on Blood Pressure
December 10, 2017 – Mary Caffrey
Heavy Healthcare Use Precedes Start of Acthar Injection for Patients With Rare Infantile Spasms
December 09, 2017 – Mary Caffrey
UC San Diego Researchers Receive $600,000 Grant to Test PI3Ky Inhibitor
December 08, 2017 – Kelly Davio
5 Approvals and Updates From the FDA This Week
December 08, 2017 – Jaime Rosenberg

Lower LDL Cholesterol Associated With Higher Mortality in American Indians

Laura Joszt
Excessively low levels of low-density lipoprotein cholesterol and triglycerides is associated with a higher all-cause mortality among American Indians, according to a new study published online ahead of print in Journal of Diabetes and Its Complications.
Excessively low levels of low-density lipoprotein (LDL) cholesterol and triglycerides are associated with a higher all-cause mortality among American Indians, according to a new study published online ahead of print in Journal of Diabetes and Its Complications.

While it is accepted that low LDL cholesterol is associated with lower mortality among whites, the same cannot be said for all populations, the authors explained. They sought to examine the effects of cholesterol and triglycerides on mortality in the American Indian population.

Beginning in 1993, triglyceride and high-density lipoprotein (HDL) cholesterol levels were reported among American Indians in the Southwest who were age 40 years or older. Patients included in the study were examined at least once between 1993 and 2007 and were followed from that first examination, considered the baseline, until death or December 31, 2011.

The researchers analyzed the effects of LDL, non-HDL, and HDL cholesterol; triglycerides; and the triglyceride:HDL cholesterol ratio on mortality. The found that, in general, lower concentrations of these serum lipids and higher levels of HDL cholesterol were “associated with increased all-cause mortality and mortality from all natural causes, liver disease, and external causes.” Meanwhile, high levels of serum lipids were associated with a greater cardiovascular mortality.

The authors hypothesized that alcohol consumption was one possible explanation for the negative associations between LDL cholesterol, non-HDL cholesterol, and triglycerides and mortality.

“American Indians are reported to have lower rates of alcohol use but higher rates of binge drinking among users than reported in national US surveys,” the authors wrote. Alcohol consumption influences lipid concentration and levels of serum cholesterol and triglycerides are reduced in patients with liver disease.

While the relatively long follow-up of this study was one strength, the authors’ inability to control for potential confounders, such as low socioeconomic status and baseline liver function, and the inability to identify underlying causes of liver disease were main limitations.

“Low cholesterol and low triglycerides are widely believed to be beneficial for health and associated with lower mortality. However, this is not universally observed, and current evidence suggests increased health risks at both ends.

 
Copyright AJMC 2006-2017 Clinical Care Targeted Communications Group, LLC. All Rights Reserved.
x
Welcome the the new and improved AJMC.com, the premier managed market network. Tell us about yourself so that we can serve you better.
Sign Up
×

Sign In

Not a member? Sign up now!