December 12, 2013 | Expiration date:
December 12, 2014Estimated time to complete activity:
2.5 hoursType of Activity:
Knowledge | Activity fee:
Free of chargeMedium:
Print with Internet-based posttest, evaluation, and request for credit.
This activity is supported by educational grants from AbbVie Inc and Bayer HealthCare Pharmaceuticals.Intended Audience
Physicians, pharmacists, and other healthcare professionals who oversee the treatment of patients with castration-resistant prostate cancer.Statement of Educational Need
Advances in early detection of prostate cancer (PrCa) have led to a significant reduction in the number of patients who are initially diagnosed with advanced stages of the disease, as evidenced by a drop from 30% to 40% of men between 1984 and 1991 to only 5% of men today. However, despite improvements in early detection, PrCa continues to be the second-highest cause of cancer-related death among men in the United States, most likely due to hormone-refractory or androgen-independent disease, which is also referred to as castration-resistant prostate cancer (CRPC). The management of CRPC continues to be a substantial clinical challenge. With up to 20% to 40% of patients with PrCa experiencing disease recurrence following primary therapy and the constant threat of further metastatic disease, advances in the understanding and manipulation of cellular signaling have led to an increased focus on the benefits of targeted therapies.
The therapeutic pipeline for advanced PrCa and CRPC is an ever expanding one, with current treatment options including secondary hormone therapy, conventional chemotherapy, and targeted immunotherapy. While there is currently no standard therapy for post docetaxel CRPC, many of the new and emerging agents, such as abiraterone acetate, cabazitaxel, and sipuleucel- T, have demonstrated significant efficacy against the disease in various clinical trials. Coupled with an increased understanding of biomarkers and improved management strategies for associated comorbidities, such as skeletal- related events and bone metastases, there is a growing optimism among clinicians and other healthcare providers as expectations and the therapeutic paradigm continue to evolve.Educational ObjectivesUpon completion of the educational activity, the participant should be able to:
Assess the incidence and clinical markers for classifying advanced prostate cancer (castration-resistant prostate cancer [CRPC])
Evaluate the importance of the prostate tumor microenvironment, including the role of the immune system, epidermal growth factor receptors, and androgen receptor signaling
Discuss current treatment approaches for CRPC, including challenges and limitations
Examine managed care aspects of managing prostate cancer, including associated direct and indirect costs, resource utilization, and cost considerations in choosing treatment
Assess strategies to integrate existing and new therapies into cancer clinical practice for treatment of advanced prostate cancer
According to the disclosure policies of the Physicians’ Education Resource®, LLC (PER), and Pharmacy Times Office of Continuing Professional Education, all persons who are in a position to control content are required to disclose any relevant financial relationships with commercial interests. If a conflict is identified, it is the responsibility of the PER® and Pharmacy Times Office of Continuing Professional Education to initiate a mechanism to resolve the conflict(s). The existence of these relationships is not viewed as implying bias or decreasing the value of the activity. All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.Physician CreditAccreditation Statement
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Physicians’ Education Resource®
, LLC, and the Pharmacy Times Office of Continuing Professional Education. Physicians’ Education Resource®
, LLC, is accredited by the ACCME to provide continuing medical education for physicians.Credit Designation
Physicians’ Education Resource®
, LLC, designates this journal-based CME activity for a maximum of 2.5 AMA PRA Category 1 Credits™
. Physicians should claim only the credit commensurate with the extent of their participation in the activity.Pharmacist CreditAccreditation and Credit Designation
Pharmacy Times Office of Continuing Professional Education is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This activity is approved for 2.5 contact hours (.25 CEUs) under the ACPE universal activity number 0290-9999-13-168-H01-P. The activity is available for CE credit through December 12, 2014.Obtaining Credit:
Each participant evaluating the activity and achieving a passing grade of 70% or higher on the posttest will receive a CME certificate or CPE statement of credit.
Indu Lew, PharmD
Vice President, Corporate Pharmacy
South Plainfield, New Jersey
Daniel P. Petrylak, MD
Director, Prostate and GU Medical Oncology
Director, Prostate Cancer Translational Research Group
Professor of Medicine, Medical Oncology
Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven
New Haven, Connecticut
Contributing Editorial Support
Elizabeth Paczolt, MD, FACNM
These faculty have disclosed the following relevant commercial financial relationships or affiliations in the past 12 months.
Daniel Petrylak, MD
Consultant or paid advisory board:
Bayer, Bellicum Pharmaceuticals, Dendreon, Exelixis, Ferring Pharmaceuticals, Johnson & Johnson, Medivation, Millennium, and sanofi-aventis
Grant support: Celgene, Dendreon, Johnson & Johnson, Millennium, OncoGenex Pharmaceuticals, and Progenics Pharmaceuticals
PDF is available on the last page.