H. Jack West, MD: There was a trial called SQUIRE that looked at a combination of cisplatin and gemcitabine with or without necitumumab, which is an anti-EGFR monoclonal antibody. This demonstrated a modest but statistically significant overall survival benefit in this challenging population with advanced squamous non—small cell lung cancer, where we really haven’t had a targeted therapy available, certainly in the first-line setting. This trial has led to the FDA approval of necitumumab.
Its use in the clinic has been limited. I think that’s just been due to a question of what we might perceive as statistical significance versus clinical significance when you’re talking about an improvement in median overall survival of less than a couple of months, adding some potential toxicities such as rash and diarrhea that can accompany anti-EGFR agents. And so, it is an option, though I don’t think it is going to be a widely practiced one. Certainly, history up until now has demonstrated that it has not been widely adopted.
It’s going to be challenging as we see more options emerge in the first-line setting for patients with squamous non—small cell lung cancer—particularly several positive trials for chemotherapy in combination with immunotherapy in the first-line setting, or immunotherapy as monotherapy for the subset of patients with historically high PD-L1 expression, and even just a 1% cutoff, as was demonstrated in a positive trial, KEYNOTE-042. So, it’s an option, though I think it’s going to be a challenged option that, historically, has not been widely used.
A Focus on Women: AUA Best Posters Highlight Female Athletes, Prenatal Care, and Women in Urology
May 9th 2024Three posters from the American Urological Association (AUA) 2024 Annual Meeting focused on urinary incontinence in female athletes, prenatal care for fetuses with spina bifida in California, and the experiences of women residents at the Brady Urological Institute.
Read More
Frameworks for Advancing Health Equity: Urban Health Outreach
May 9th 2024In the series debut episode of "Frameworks for Advancing Health Equity," Mary Sligh, CRNP, and Chelsea Chappars, of Allegheny Health Network, explain how the Urban Health Outreach program aims to improve health equity for individuals experiencing homelessness.
Listen
Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
Listen