Timothy M. Johnson, MD, spoke enthusiastically about the possibilities of sentinel lymph node biopsy in his lecture at the 25th European Academy of Dermatology and Venereology Congress in Vienna, Austria. His presentation, called “Melanoma Sentinel Node Biopsy: Past, Present and Future in the New Era of Systemic Therapies,” covered guidelines for the procedure as well as new possibilities for melanoma patients.
Timothy M. Johnson, MD, spoke enthusiastically about the possibilities of sentinel lymph node biopsy (SLNB) in his lecture at the 25th European Academy of Dermatology and Venereology Congress in Vienna, Austria. His presentation, called “Melanoma Sentinel Node Biopsy: Past, Present and Future in the New Era of Systemic Therapies,” covered guidelines for the procedure as well as new possibilities for melanoma patients.
Johnson, who is the Lewis and Lillian Becker Professor of Dermatology at the University of Michigan, began his presentation by acknowledging that many dermatologists may not be well informed about the use of SLNB in treating melanoma, but he feels it is worth researching. “As a dermatologist, your patients will view you as their primary melanoma physician. They will look to you for guidance and counseling, including sentinel lymph node biopsy,” he said.
SLNB is a procedure in which a clinician identifies, removes, and examines the sentinel lymph node, or the lymph node to which cancer cells are most likely to spread from a tumor. Johnson explained that many patients do not fall within the guidelines to be considered for this type of biopsy, which must be performed in an operating room with general anesthesia. It is not recommended for patients with multiple comorbidities, for instance.
But for those who are eligible, he said, the procedure can have great benefit. Accuracy of tumor staging determines treatment options, and SLNB is “the gold standard test of sensitivity and specificity for staging.”
Researchers still have much to learn about SLNB, like the false negative rate and the survival subset benefit. Johnson said it was possible that if further studies of SLNB do not support its utility, it would no longer be recommended.
However, the research surrounding SLNB demonstrates that melanoma tests and treatments are in an exciting new era. The first drugs for stage IV melanoma came out only 6 years ago, and since then there has been huge growth, according to Johnson.
"This was unheard of when I started 30 years ago and it’s just, again, such an exciting time,” he said.
One of SLNB’s greatest potential uses is in determining the need for adjuvant therapy and which therapy would be most effective. Melanoma is “probably one of the hardest of all tumors to crack” because it is so heterogeneous that one single course of treatment cannot possibly work on every patient.
Johnson encouraged the audience to do their research and treat each patient as if they were a family member. Although dermatologists need to be the “lead dog” on the patient’s melanoma management team, he stressed that they “must work with other specialists collegiately, collaboratively, and humbly.”
Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
Listen
Budesonide-Based Triple Therapy Shows Best Benefit Over Dual Therapy for COPD
May 8th 2024The triple therapy of budesonide, glycopyrrolate, and formoterol fumarate showed the greatest incremental net benefit among a series of triple therapy medications that were evaluated against dual therapy for chronic obstructive pulmonary disease (COPD), according to an analysis presented at ISPOR.
Read More
Oncology Onward: A Conversation With Penn Medicine's Dr Justin Bekelman
December 19th 2023Justin Bekelman, MD, director of the Penn Center for Cancer Care Innovation, sat with our hosts Emeline Aviki, MD, MBA, and Stephen Schleicher, MD, MBA, for our final episode of 2023 to discuss the importance of collaboration between academic medicine and community oncology and testing innovative cancer care delivery in these settings.
Listen
AUA Session Highlights the General Urologist’s Role in Gender-Affirming Care
May 7th 2024During her session, Polina Reyblat, MD, Kaiser Permanente Los Angeles Medical Center, highlighted best practices urologists should incorporate to make transgender and gender-diverse patients comfortable during physical exams and avoid retraumatization.
Read More