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Supplements Implications of Early Treatment for Parkinson’s Disease [CME/CPE]

Early Pharmacologic Treatment in Parkinson's Disease

Robert A. Hauser, MD, MBA




Conclusion

Early treatment of PD offers the opportunity to forestall clinical progression. MAO-B inhibitors provide mild symptomatic benefit, are very well tolerated, and may provide long-term disease-modifying effects. Dopamine agonists provide moderate symptomatic efficacy and delay the onset of motor complications, but are associated with somnolence and sudden-onset sleep, and impulse control disorders. Levodopa, administered with a DDI, provides the greatest symptomatic benefit but is associated with the development of motor fluctuations and dyskinesias. The optimal selection of medications for each patient very much depends on their anticipated individual risk for side effects and need for symptomatic improvement.

Author Affiliations: Departments of Neurology, Molecular Pharmacology and Physiology, University of South Florida, Tampa.

Funding Source: Financial support for this work was provided by Teva Neurosciences, Inc.

Author Disclosure: Dr Hauser has received honoraria from the following companies for consulting, advisory, or speaking services: Allergan Neuroscience, Biogen Idec, Boehringer Ingelheim, Embryon, GE Healthcare, Genzyme, GlaxoSmithKline, Impax, Ipsen Pharmaceuticals, Kyowa Pharmaceutical, Merck Serono International, Novartis, Quintiles, Santhera, Schering Plough, Solvay, Synosia Therapeutics, Teva Neuroscience, UCB, and Xenoport.

Authorship Information: Concept and design; analysis and interpretation of data; drafting of the manuscript; and critical revision of the manuscript for important intellectual content.

Address correspondence to: Robert A. Hauser, MD, MBA, USF Health-Movement Disorders Center, 5 Tampa General Circle, Harbourside Medical Tower, Ste 410, Tampa, FL 33606. E-mail: rhauser@health.usf.edu.

 

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