The AJMC® Lupus compendium is a comprehensive resource for clinical news and expert insights for the inflammatory disease that occurs when the immune system attacks its own tissues.

Severe SLE Flares Negatively Impact Health Care-Related Quality of Life, Study Finds

May 18th 2022, 11:15am


The pain, planning, emotional health, and fatigue quality of life domains were most impacted as a result of severe systemic lupus erythematosus (SLE) flares.

miRNA-499 Gene Polymorphism Tied to Autoimmune Disease Risk, Analysis Shows

May 15th 2022, 1:44pm


The study found associations between miRNA-499 polymorphism and autoimmune disease risk in Caucasian and Asian populations, including a significantly increased risk of rheumatoid arthritis and systemic lupus erythematosus.

Higher Lupus-Associated Flare Risk Seen in Patients With Normal-Looking Skin

May 12th 2022, 7:28pm


This new research may help investigators prevent skin lesions.

Study Probes Multi-Omics Interactions at Play in SLE Pathogenesis

May 9th 2022, 7:28pm


The study highlights differences between patients with systemic lupus erythematosus (SLE) and healthy controls, potentially shedding light on the disease’s underlying mechanisms.

Study: Cognitive Impairment Has Little Effect on QOL in SLE

May 6th 2022, 3:03pm


Investigators found quality of life (QOL) effects may be tied to patients’ perceptions of cognitive impairment, rather than objective measurements of impairment from systemic lupus erythematosus (SLE).

Study Shows TLR7 Variation Plays Key Role in SLE Development

May 2nd 2022, 5:47pm


The study showed that introducing the TLR7 variant in an animal model led to the development of autoimmune symptoms and potential development of systemic lupus erythematosus (SLE).

Study: Refractory Headache in Children With SLE Could Be a Sign of Intracranial Hypertension

April 25th 2022, 8:30pm


Clinicians should be vigilant and perform neurological and ophthalmological examinations in patients with persistent headaches, the authors said.

Lack of Awareness, Cultural Barriers Impact Racial, Ethnic Groups Hit Hardest by SLE, CLE

April 21st 2022, 3:49pm


Patient education is an important step toward improving outcomes for racial and ethnic groups disproportionately affected by lupus, but a new report suggests payers and physicians also have more to learn about the problem.

Role of B1 Cells in SLE Is Better Understood, but Questions Remain

April 19th 2022, 8:01pm


A new review article highlights a number of roles for B1 cells, including antibody secretion and the stimulation of CD4+ cells.

Research Explores Dysregulation of IRF8 in Development of Autoimmune Disease

April 14th 2022, 10:53am


The research could pave the way for therapies that target enhancers of disease-related genes.