Lupus

The AJMC® Lupus compendium is a comprehensive resource for clinical news and expert insights for the inflammatory disease that occurs when the immune system attacks its own tissues.

Latest News
June 24th 2025

FDA Approves At-Home Belimumab Autoinjector for Pediatric Lupus Nephritis

December 27th 2022

Top 5 Most-Read Lupus Articles of 2022

December 14th 2022

Case Report Details Rare Case of SLE With Cutaneous Leukocytoclastic Vasculitis

December 10th 2022

Physical Activity Benefits People With SLE, but Many Do Not Meet WHO Guidelines

December 6th 2022

New Data Suggest Biomarker for SLE Therapy Response

Video Interviews
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December 15th 2022

Dr Liz Lightstone: Lupus Nephritis Misconceptions Contributing to Underdiagnosis, Low-Value Care

December 8th 2022

Considerations for LN Treatment Selection

December 8th 2022

LN Treatment Landscape Overview

December 3rd 2022

Dr Liz Lightstone on Race and Sociodemographic Implications in Lupus Nephritis

December 1st 2022

Patient Goals in Treatment of LN

December 1st 2022

Drivers of Health Care Utilization in Patients With LN

November 25th 2022

Dr Liz Lightstone Explains Impact of Pregnancy, Fertility on Clinical Trial Recruitment for Lupus Nephritis

November 23rd 2022

Emphasizing Urgent Treatment and Guideline-Directed Therapies for Patients with LN

November 23rd 2022

Disease Progression of LN from SLE

November 18th 2022

Dr Liz Lightstone Discusses Implications of Current Standard of Care for Lupus Nephritis

More News

Initial Presentation of Lupus Nephritis
November 17th 2022

Initial Presentation of Lupus Nephritis

Medical experts illustrate characteristics in the presentation of lupus nephritis.
Overview of Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN)
November 17th 2022

Overview of Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN)

Alvin Wells, MD, PhD, opens a discussion surrounding systemic lupus erythematosus (SLE) and lupus nephritis (LN).
graphic depicting lupus
November 16th 2022

Belimumab Provides Benefit in Cutaneous Lupus Erythematosus, With or Without SLE

Patrick Campbell
A systematic review and meta-analysis presented at ACR Convergence 2022 provide insight into the effects of belimumab in patient populations with cutaneous lupus erythematosus, with or without systemic lupus erythematosus (SLE).
Image of Mayo Clinic
November 15th 2022

Data Suggest CLE Incidence Has Not Changed Significantly in 40 Years

Jared Kaltwasser
Authors also found that the mortality rate of people with cutaneous lupus erythematosus (CLE) are generally similar to that of the general population.
Dr Liz Lightstone on Emerging Treatment Options, Unmet Needs in Lupus Nephritis
November 11th 2022

Dr Liz Lightstone on Emerging Treatment Options, Unmet Needs in Lupus Nephritis

Matthew Gavidia
Liz Lightstone, MBBS, PhD, FRCP, professor of renal medicine for the faculty of medicine, Imperial College London, discussed recently approved therapeutic options for patients with lupus nephritis and what unmet needs persist in the management of the disease.
Image of a lot of people
November 5th 2022

SLE Prevalence Varies Across Low- and Middle-Income Countries

Jared Kaltwasser
Colombia and Brazil had the highest prevalence and incidence of systemic lupus erythematosus (SLE), a new investigation found.
Image of SARS-CoV-2
November 3rd 2022

Genetic Susceptibility to SLE May Protect Against Severe COVID-19

Jared Kaltwasser
A new report found interesting links between genetic factors associated with COVID-19 severity and autoimmune disease among persons who have systemic lupus erythematosus (SLE).
Graphic of a person on top of a question mark
October 29th 2022

With Systemic Lupus Erythematosus, Finding a Cause Is No Simple Task

Jared Kaltwasser
Existing evidence suggests genetics, environmental factors, and exposure to specific chemicals—such as those in cigarettes—can all increase a person’s risk of systemic lupus erythematosus.
Image of silhoutted children child
October 25th 2022

Long-term Childhood Lupus Nephritis Outcomes Appear to Be Improving

Jared Kaltwasser
These new study data are based on 20 years of follow-up in 92 Chinese children with lupus nephritis.
Image of patients of many races
October 22nd 2022

Racial Disparities Correlate With COVID-19 Outcomes in People With SLE

Jared Kaltwasser
Blacks and Hispanics with systemic lupus erythematosus (SLE) are more than twice as likely to have severe outcomes from COVID-19 compared with White patients with SLE, a new study has found.
Image of the world
October 19th 2022

SLE Rates Vary Worldwide and Require Further Study, Study Emphasizes

Jared Kaltwasser
Data suggest incidence and prevalence of systemic lupus erythematosus (SLE) vary widely among regions, although the authors noted some regions have been studied more extensively than others.
graphic illustrating a person with rare condition
October 15th 2022

In Rare Cases, Hypoparathyroidism Can Be Linked With SLE

Jared Kaltwasser
Only about 10 cases of hypoparathyroidism related to systemic lupus erythematosus (SLE) have been reported, according to researchers who recently described such a case.
graphic of a question mark with a stethoscope
October 12th 2022

Hydroxychloroquine for Primary Sjögren Syndrome Does Not Lower Risk of SLE

Jared Kaltwasser
However, the researchers said their findings should not be interpreted as completely refuting the possibility that hydroxychloroquine might be a useful tool in preventing or slowing the development of systemic lupus erythematosus (SLE).
Physician reviewing a case report
October 8th 2022

Importance of Jaccoud Arthropathy Investigation Highlighted in SLE Case Report

Jared Kaltwasser
The question of whether bone erosion is a feature of Jaccoud arthropathy has remained controversial among persons who have systemic lupus erythematosus (SLE).
Image of female patient and doctor having consultation
October 4th 2022

Different Drugs Affect SLE Quality of Life Differently, Study Finds

Jared Kaltwasser
The research shows a disease-specific quality-of-life (QOL) tool is more sensitive than a generic version.
Doc and patient discussing care report
September 25th 2022

Case Report: Complicated Case of SLE, Infection Required Nonstandard Treatment Choice

Jared Kaltwasser
The patient was successfully treated with rituximab and intravenous immunoglobulin.
Doc writing a case report
September 19th 2022

Late-Onset SLE Case Underscores Possibilities of Unusual Presentation

Jared Kaltwasser
The case involved a 69-year-old man who presented with lupus nephritis.
Image of lab research
September 15th 2022

Shifting Landscape, Role of Belimumab in SLE and Lupus Nephritis Explored

Jared Kaltwasser
A new review article explains the role of biologics in treatment systemic lupus erythematosus (SLE) and lupus nephritis.
Image of painful hands
September 13th 2022

Phase 2 Study Finds Litifilimab Improves Joint Arthritis in SLE

Jared Kaltwasser
New data show litifilimab outperformed placebo in patients with active arthritis and skin manifestations due to systemic lupus erythematosus (SLE).
image of cardiac care
September 7th 2022

Lupus Anticoagulant Linked With Cardiac Dysfunction in SLE

Jared Kaltwasser
The authors found the association by comparing echocardiographic and biochemical changes after 5 years in patients with systemic lupus erythematosus (SLE).
woman who is depressed
September 6th 2022

Anxiety, Depression Common in People With SLE and Lupus Nephritis

Jared Kaltwasser
A new study finds anxiety and depression are more common in people with systemic lupus erythematosus (SLE) if they also have nephritis.
Picture of an adult and child
August 31st 2022

Useful Similarities Between Adult, Pediatric SLE Study Data Found

Jared Kaltwasser
The findings mean it may be feasible to use adult systemic lupus nephritis (SLE) trial data to reduce the data needed for pediatric indications.
Silhouetted image of children
August 26th 2022

Lupus Nephritis Care Varies Widely in Children With SLE

Jared Kaltwasser
The use of existing guidelines for pediatric treatment varies significantly among sites, a new study has found.
Image of cardiovascular health
August 22nd 2022

More Work Needed to Make Progress Against CVD Risk in SLE

Jared Kaltwasser
A new review outlines what is known about cardiovascular disease (CVD) risk in patients with systemic lupus erythematosus (SLE) and how that might affect patient care.
Picture of globe
August 17th 2022

New Report Highlights Rare Cases of SLE Onset After HPV Vaccination

Jared Kaltwasser
A new case report highlights the potential benefits of risk assessment for women with a family history of autoimmune diseases, such as systemic lupus erythematosus (SLE), who are considering the human papillomavirus (HPV) vaccine.
Image of a biomarker
August 13th 2022

Fibrinogen to Albumin Ratio Shows Promise as SLE Predictive Biomarker

Jared Kaltwasser
This ratio could be used to better predict disease activity and poor prognosis.
Image of a child and their patient
August 11th 2022

Potential Proteinuria Biomarkers in Pediatric LN Identified

Jared Kaltwasser
Elevated levels of HER2, VCAM, and TWEAK indicated proteinuria, study authors say of their new findings.
Image of case reports
August 6th 2022

Rare Instance of Simultaneous SLE, TTP Presentation Described in New Case Report

Jared Kaltwasser
Investigators said they were able to confirm diagnoses of systemic lupus erythematosus (SLE) and thrombotic thrombocytopenic purpura (TTP) because they took a multidisciplinary approach.
Image of scientific research
August 2nd 2022

New Therapies on Horizon as Science of CLE Advances

Jared Kaltwasser
Investigators say recent research into the development of cutaneous lupus erythematosus has created the potential for new therapies.
Enhanced images of the human body
July 26th 2022

SLE, Cardiovascular Disease Have Complex Interplay

Jared Kaltwasser
A new study highlights potential therapies to decrease cardiovascular risk in people with systemic lupus erythematosus (SLE) and identifies biomarkers that may indicate a heightened risk.
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