Lupus

A new review article outlines current agreements and disagreements between association guidelines, but notes the recommendations are likely to change more in the future.

A booster dose of a SARS-CoV-2 vaccine cut infection risk nearly in half, study finds.

A narrative review shows that diagnosing systemic lupus erythematosus (SLE) requires physicians to keep an open and inquisitive mind.

Investigators note that the most recent systemic lupus erythematosus (SLE) classification system has quickly become the gold standard, but disease classification remains challenging.

The tool relies on factors including creatinine, anti–double-stranded DNA antibody, and gender, among others.

About 43% of patients experienced complete depletion of B cells after the first round of rituximab, and those patients had greater odds of longer-term success.

A single-center analysis of more than 30 years of data shows rates of preterm births and preeclampsia remained stable

The investigators cautioned, however, that the factors identified had only modest predictive power.

The study, based on 33 years of data, also explored auto-antibody production in the rare patient group.

Levels of the 2 markers appeared to indicate both the presence of SLE and disease activity levels.

Forty-two percent of patients in the cohort had an adverse pregnancy outcome.

Patients with higher levels of interferon-β (IFNβ) in their B cells were less likely to have oral and nasal ulcers or photosensitivity.

Patients of Asian heritage were also more likely to have end-organ manifestation, the authors found.

The pain, planning, emotional health, and fatigue quality of life domains were most impacted as a result of severe systemic lupus erythematosus (SLE) flares.

The study found associations between miRNA-499 polymorphism and autoimmune disease risk in Caucasian and Asian populations, including a significantly increased risk of rheumatoid arthritis and systemic lupus erythematosus.

This new research may help investigators prevent skin lesions.

The study highlights differences between patients with systemic lupus erythematosus (SLE) and healthy controls, potentially shedding light on the disease’s underlying mechanisms.

Investigators found quality of life (QOL) effects may be tied to patients’ perceptions of cognitive impairment, rather than objective measurements of impairment from systemic lupus erythematosus (SLE).

The study showed that introducing the TLR7 variant in an animal model led to the development of autoimmune symptoms and potential development of systemic lupus erythematosus (SLE).

Clinicians should be vigilant and perform neurological and ophthalmological examinations in patients with persistent headaches, the authors said.

Patient education is an important step toward improving outcomes for racial and ethnic groups disproportionately affected by lupus, but a new report suggests payers and physicians also have more to learn about the problem.

A new review article highlights a number of roles for B1 cells, including antibody secretion and the stimulation of CD4+ cells.

The research could pave the way for therapies that target enhancers of disease-related genes.

Black children with systemic lupus erythematosus (SLE) are at the highest risk of adverse renal outcomes, the study found.

Of 5 RNA investigated, 2 correlated with systemic lupus erythematosus and the last correlated with certain inflammation-related symptoms.

The report is based on a series of 10 cases and a literature review involving 14 cases.

Investigators also studied omega-6, but they found no evidence that it is involved in causing systemic lupus erythematosus (SLE).

The mortality rate for patients with systemic lupus erythematosus (SLE) was greater than one-third if they were admitted to an intensive care unit (ICU).

The QRISK3 model outperformed more traditional models like the Framingham Risk Score, according to a new report.

The results of a new longitudinal analysis cast doubt on the utility of serial interferon assessment.