Lupus

The study showed that introducing the TLR7 variant in an animal model led to the development of autoimmune symptoms and potential development of systemic lupus erythematosus (SLE).

Clinicians should be vigilant and perform neurological and ophthalmological examinations in patients with persistent headaches, the authors said.

Patient education is an important step toward improving outcomes for racial and ethnic groups disproportionately affected by lupus, but a new report suggests payers and physicians also have more to learn about the problem.

A new review article highlights a number of roles for B1 cells, including antibody secretion and the stimulation of CD4+ cells.

The research could pave the way for therapies that target enhancers of disease-related genes.

Black children with systemic lupus erythematosus (SLE) are at the highest risk of adverse renal outcomes, the study found.

Of 5 RNA investigated, 2 correlated with systemic lupus erythematosus and the last correlated with certain inflammation-related symptoms.

The report is based on a series of 10 cases and a literature review involving 14 cases.

Investigators also studied omega-6, but they found no evidence that it is involved in causing systemic lupus erythematosus (SLE).

The mortality rate for patients with systemic lupus erythematosus (SLE) was greater than one-third if they were admitted to an intensive care unit (ICU).

The QRISK3 model outperformed more traditional models like the Framingham Risk Score, according to a new report.

The results of a new longitudinal analysis cast doubt on the utility of serial interferon assessment.

New subsets of patients with systemic lupus erythematosus (SLE) and new therapeutic targets have been discovered in recent years.

Immunoglobulins, free light chains, and beta-2 microglobulin all show promise in tracking systemic lupus erythematosus (SLE) and other autoimmune diseases.

Several potential biomarkers have emerged, although most still require significant validation before they can be used in the clinic.

A range of new non-serum biomarkers have been identified in recent years, but the authors of a new review urge caution until those markers are further validated.

Serum levels of 4 key cytokines were decreased after 8 weeks of mild exercise, compared with controls.

Central Mexican women and women from Yucatán both had risk factors for systemic lupus erythematosus, but they differed in type and degree of risk.

The report builds upon existing research into metabolic biomarkers, identifying 14 differential biomarkers in patients with systemic lupus erythematosus and skin involvement.

The new one-page tool can be completed about 20 minutes faster than the older form, but it is also more accurate, investigators said.

According to a recent study, nearly 50% of patients with connective tissue disease, such as lupus, died when sepsis occurred.

Predictive markers may make it easier to figure out which patients require the often costly and invasive measures needed to confirm the coronary complication in patients with systemic lupus erythematosus.

The report suggests remission and disease activity state alone are not the most important risk factors in pregnant women with well-controlled systemic lupus erythematosus.

A new retrospective analysis proposes cutoff values that could help physicians identify patients at highest risk of severe kidney complications.

New evidence suggests macrophage regulation could be an important area of inquiry in systemic lupus erythematosus, but the research is in its early stages.