Lupus

New subsets of patients with systemic lupus erythematosus (SLE) and new therapeutic targets have been discovered in recent years.

Immunoglobulins, free light chains, and beta-2 microglobulin all show promise in tracking systemic lupus erythematosus (SLE) and other autoimmune diseases.

Several potential biomarkers have emerged, although most still require significant validation before they can be used in the clinic.

A range of new non-serum biomarkers have been identified in recent years, but the authors of a new review urge caution until those markers are further validated.

Serum levels of 4 key cytokines were decreased after 8 weeks of mild exercise, compared with controls.

Central Mexican women and women from Yucatán both had risk factors for systemic lupus erythematosus, but they differed in type and degree of risk.

The report builds upon existing research into metabolic biomarkers, identifying 14 differential biomarkers in patients with systemic lupus erythematosus and skin involvement.

The new one-page tool can be completed about 20 minutes faster than the older form, but it is also more accurate, investigators said.

According to a recent study, nearly 50% of patients with connective tissue disease, such as lupus, died when sepsis occurred.

Predictive markers may make it easier to figure out which patients require the often costly and invasive measures needed to confirm the coronary complication in patients with systemic lupus erythematosus.

The report suggests remission and disease activity state alone are not the most important risk factors in pregnant women with well-controlled systemic lupus erythematosus.

A new retrospective analysis proposes cutoff values that could help physicians identify patients at highest risk of severe kidney complications.

New evidence suggests macrophage regulation could be an important area of inquiry in systemic lupus erythematosus, but the research is in its early stages.

The new study suggests certain sub-categories of patients are at particularly high risk.

The patient had no obvious pulmonary symptoms, but a routine chest X-ray helped investigators arrive at the diagnosis.

The new recommendations for systemic lupus erythematosus (SLE) use disease activity index scores and evaluator’s global assessment measures, but they do not include serology.

Research on belimumab, mean platelet volume, and how lupus is linked with other autoimmune diseases appeared in AJMC.com's top 5 most-read lupus articles of 2021.

A new report finds patients with systemic lupus erythematosus and 5 other autoimmune disorders face an increased risk of gastric cancers.

The patient experienced lasting improvement when belimumab was added to her regimen after 2 years.

Women with systemic lupus erythematosus (SLE) were twice as likely to experience carotid plaque buildup during the 5 years of this study.

Investigators found anti-ribosomal P protein antibodies, a serological marker for systemic lupus erythematosus (SLE), were linked with higher ferritin levels, independent of interleukin 6 levels.

Patients who took supplements had improvements, although they did not become apparent until patients had been taking supplements for a year.

Patients with SLE had higher levels of Wnt5A if they were experiencing active disease.

Dutch investigators found a screening questionnaire might be a good tool to identify patients warranting further testing for systemic lupus erythematosus (SLE).

Five gene hubs were identified, with one in particular appearing to correlate strongly with the pathogenesis of lupus nephritis.

A re-evaluation of patients found most had intermediate lupus erythematosus, even though the vast majority were initially diagnosed with the limited-cutaneous form of the disease.

In both blood and urine samples, patients with systemic lupus erythematosus and renal involvement were found to have higher levels of interleukin-35 compared with patients with systemic lupus erythematosus and no known renal involvement.

The report suggests childcare concerns could be a significant factor keeping Black women from attending weekly workshops.

Patients with lupus nephritis (LN) were found to have as much as twice the inpatient hospitalizations of patients with systemic lupus erythematosus without LN.

Cost increases were particularly pronounced among patients with severe systemic lupus erythematosus (SLE), the study found.