Lupus

The AJMC® Lupus compendium is a comprehensive resource for clinical news and expert insights for the inflammatory disease that occurs when the immune system attacks its own tissues.

Latest News

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FDA Approves At-Home Belimumab Autoinjector for Pediatric Lupus Nephritis

June 24th 2025

Belimumab is now the first and only subcutaneous biologic therapy approved for at-home administration in pediatric lupus nephritis.

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Top 5 Most-Read Lupus Articles of 2022

December 27th 2022

Doctor reading a patient report
Case Report Details Rare Case of SLE With Cutaneous Leukocytoclastic Vasculitis

December 14th 2022

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Physical Activity Benefits People With SLE, but Many Do Not Meet WHO Guidelines

December 10th 2022

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New Data Suggest Biomarker for SLE Therapy Response

December 6th 2022

More News

Genes and DNA
March 2nd 2022

Type 1 Interferon Status Usually Stable in Patients With Systemic Lupus Erythematosus

Jared Kaltwasser
The results of a new longitudinal analysis cast doubt on the utility of serial interferon assessment.
Scientists using microscope in lab
February 22nd 2022

New Research Elucidates Role of B Cells in SLE

Jared Kaltwasser
New subsets of patients with systemic lupus erythematosus (SLE) and new therapeutic targets have been discovered in recent years.
Image of b-cell activation
February 17th 2022

B-Cell Biomarkers Emerging in SLE, but With Important Caveats

Jared Kaltwasser
Immunoglobulins, free light chains, and beta-2 microglobulin all show promise in tracking systemic lupus erythematosus (SLE) and other autoimmune diseases.
Image of DNA
February 14th 2022

In Childhood SLE, Quest for Biomarkers Is Making Progress

Jared Kaltwasser
Several potential biomarkers have emerged, although most still require significant validation before they can be used in the clinic.
researchers in a lab
February 11th 2022

Review: New Biomarkers Explored in SLE, but Need Exists for More Validation

Jared Kaltwasser
A range of new non-serum biomarkers have been identified in recent years, but the authors of a new review urge caution until those markers are further validated.
woman running
February 8th 2022

Study: Exercise May Decrease Inflammatory Cytokines in Patients With SLE

Jared Kaltwasser
Serum levels of 4 key cytokines were decreased after 8 weeks of mild exercise, compared with controls.
DNA graphic
February 2nd 2022

Comparison of Mexican Ethnic Groups Shows Genetic Factors Heighten SLE Risk

Jared Kaltwasser
Central Mexican women and women from Yucatán both had risk factors for systemic lupus erythematosus, but they differed in type and degree of risk.
people
January 31st 2022

Study: Metabolic Analysis Could Indicate Skin Involvement in SLE

Jared Kaltwasser
The report builds upon existing research into metabolic biomarkers, identifying 14 differential biomarkers in patients with systemic lupus erythematosus and skin involvement.
red cross
January 25th 2022

New Easy-BILAG Tool Cuts Time, Boosts Accuracy of SLE Progression Tracking

Jared Kaltwasser
The new one-page tool can be completed about 20 minutes faster than the older form, but it is also more accurate, investigators said.
Connective Tissue Diseases, Sepsis Lead to Higher Mortality Risk
January 23rd 2022

Connective Tissue Diseases, Sepsis Lead to Higher Mortality Risk

Jared Kaltwasser
According to a recent study, nearly 50% of patients with connective tissue disease, such as lupus, died when sepsis occurred.
Understanding Which Patients With SLE May Also Develop PAH
January 22nd 2022

Understanding Which Patients With SLE May Also Develop PAH

Jared Kaltwasser
Predictive markers may make it easier to figure out which patients require the often costly and invasive measures needed to confirm the coronary complication in patients with systemic lupus erythematosus.
pregnant woman
January 18th 2022

Report Outlines New Risk Factors for Adverse Pregnancy Outcomes in SLE

Jared Kaltwasser
The report suggests remission and disease activity state alone are not the most important risk factors in pregnant women with well-controlled systemic lupus erythematosus.
kidney graphic
January 12th 2022

Two Biomarkers Predictive of ESRD in Patients With Lupus Nephritis

Jared Kaltwasser
A new retrospective analysis proposes cutoff values that could help physicians identify patients at highest risk of severe kidney complications.
image of molecules
January 10th 2022

New Review Outlines Potential Role of Macrophages in SLE Development, Treatment

Jared Kaltwasser
New evidence suggests macrophage regulation could be an important area of inquiry in systemic lupus erythematosus, but the research is in its early stages.
graphic of people
January 7th 2022

HCQ Tapering, Discontinuation Heighten Flare Risk in Some Patients With SLE

Jared Kaltwasser
The new study suggests certain sub-categories of patients are at particularly high risk.
patients and doctors graphic
January 4th 2022

Report Details Rare Lymphocytic Interstitial Pneumonia Case in Patient with SLE

Jared Kaltwasser
The patient had no obvious pulmonary symptoms, but a routine chest X-ray helped investigators arrive at the diagnosis.
What Counts as Remission in SLE? Task Force Releases Recommendations
December 27th 2021

What Counts as Remission in SLE? Task Force Releases Recommendations

Jared Kaltwasser
The new recommendations for systemic lupus erythematosus (SLE) use disease activity index scores and evaluator’s global assessment measures, but they do not include serology.
Top 5 Lupus Articles of 2021
December 24th 2021

Top 5 Most-Read Lupus Articles of 2021

Hayden E. Klein
Research on belimumab, mean platelet volume, and how lupus is linked with other autoimmune diseases appeared in AJMC.com's top 5 most-read lupus articles of 2021.
Cancer cells
December 20th 2021

SLE, Other Autoimmune Diseases Linked With Gastric Cancers

Jared Kaltwasser
A new report finds patients with systemic lupus erythematosus and 5 other autoimmune disorders face an increased risk of gastric cancers.
pills and syringe
December 16th 2021

Case Report Shows Positive Outcome With Belimumab for CTD-Associated Interstitial Lung Disease

Jared Kaltwasser
The patient experienced lasting improvement when belimumab was added to her regimen after 2 years.
graphic of arteries
December 14th 2021

Study Identifies Risk Factors for Carotid Intima Media Thickness Progression in SLE

Jared Kaltwasser
Women with systemic lupus erythematosus (SLE) were twice as likely to experience carotid plaque buildup during the 5 years of this study.
Serological Marker Linked With Higher Ferritin, Macrophage Activation, in SLE
December 11th 2021

Serological Marker Linked With Higher Ferritin, Macrophage Activation, in SLE

Jared Kaltwasser
Investigators found anti-ribosomal P protein antibodies, a serological marker for systemic lupus erythematosus (SLE), were linked with higher ferritin levels, independent of interleukin 6 levels.
vitamin bottle
December 8th 2021

Patients With SLE May Benefit From Vitamin D Supplementation, Study Finds

Jared Kaltwasser
Patients who took supplements had improvements, although they did not become apparent until patients had been taking supplements for a year.
workers in a lab
December 6th 2021

Investigators Find Potential Biomarker for SLE Severity

Jared Kaltwasser
Patients with SLE had higher levels of Wnt5A if they were experiencing active disease.
Questionnaire May Facilitate Earlier SLE Diagnosis, Study Suggests
November 29th 2021

Questionnaire May Facilitate Earlier SLE Diagnosis, Study Suggests

Jared Kaltwasser
Dutch investigators found a screening questionnaire might be a good tool to identify patients warranting further testing for systemic lupus erythematosus (SLE).
gene graphic
November 26th 2021

Analysis Identifies Possible Biomarkers for Lupus Nephritis in SLE

Jared Kaltwasser
Five gene hubs were identified, with one in particular appearing to correlate strongly with the pathogenesis of lupus nephritis.
Microscope
November 19th 2021

Two-Dimensional Approach Leads to Significant Revisions of LE Classifications

Jared Kaltwasser
A re-evaluation of patients found most had intermediate lupus erythematosus, even though the vast majority were initially diagnosed with the limited-cutaneous form of the disease.
kidneys
November 16th 2021

Study Identifies Association Between IL-35, Lupus Nephritis in SLE

Jared Kaltwasser
In both blood and urine samples, patients with systemic lupus erythematosus and renal involvement were found to have higher levels of interleukin-35 compared with patients with systemic lupus erythematosus and no known renal involvement.
Age, Work Status Affect Self-management Workshop Participation in Black Women With SLE
November 10th 2021

Age, Work Status Affect Self-management Workshop Participation in Black Women With SLE

Jared Kaltwasser
The report suggests childcare concerns could be a significant factor keeping Black women from attending weekly workshops.
Review: Lupus Nephritis Leads to Spike in Health Care Costs, Utilization
November 8th 2021

Review: Lupus Nephritis Leads to Spike in Health Care Costs, Utilization

Jared Kaltwasser
Patients with lupus nephritis (LN) were found to have as much as twice the inpatient hospitalizations of patients with systemic lupus erythematosus without LN.
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