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Supplements Multiple Sclerosis: A Review of Diagnosis and Management

Beyond Efficacy and Safety: Where We Go From Here in the Management of Multiple Sclerosis

Introduction

When selecting a disease-modifying therapy (DMT) for patients with multiple sclerosis (MS), clinicians must first consider the efficacy and safety of the agent.1 Other considerations include initiating treatment as early as possible, adherence to current and subsequent DMTs, understanding when to switch patients from their current DMTs to other medications (and knowing when not to switch), and cost factors.2-5

Although the currently approved DMTs are reliable, constantly being improved, effective in treating relapses, and able to reduce long-term disability, they have only limited efficacy in treating progressive disease that is not associated with inflammatory relapses.6 More effective DMTs are needed specifically for patients with primary progressive MS. Likewise, agents that repair or regenerate neurons, oligodendrocytes, and supporting glia are essential for effective treatment.7

Several new medications have entered the market in recent years and others are in late-phase clinical studies for the treatment of patients with relapsing or progressive forms of MS.8 These agents represent a variety of mechanisms of action, providing not only lower relapse rates but also improvement in disabilities.

Importance of Early Diagnosis and Early Treatment

MS is characterized by both inflammation and progressive neuroaxonal damage.9 Although this damage often occurs in the early stages of disease, it may be masked by compensatory mechanisms. Thus, progressive damage may go unrecognized until it is too late for intervention to be beneficial. As MS progresses, the balance between the degenerative and the reparative processes shifts, resulting in progressive neuroaxonal degeneration and increasing disability (see Figure 1).9

Because brain atrophy creates permanent damage, and correlates with physical and cognitive disability, it is important for patients with MS to be treated with DMTs as early in the disease course as possible, in order to decrease the loss of brain volume and its effects.2 Additionally, patients with clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) who are at high risk for the development of clinically definite MS (CDMS) should also be treated with DMTs as soon as possible.

Several clinical trials have provided proof of concept for an early window of initial treatment intervention in patients with CIS.9 Significant reductions in the risk for developing CDMS were observed with the use of interferon beta agents and glatiramer acetate when treatment was initiated early on. Physical disability and number and/or volume of brain lesions were also improved with early treatment. Similar results have been reported with some of the newer DMTs, such as teriflunomide, alemtuzumab, and fingolimod.

Adherence to Disease-Modifying Therapies 

According to the World Health Organization (WHO), adherence is defined as “the extent to which a person’s behavior—taking medication, following a diet, and/or executing lifestyle changes— corresponds with agreed recommendations from a health care provider.”10,11 There are 3 distinct components of adherence: (1) acceptance,  (2) persistence, and (3) compliance.10,12 Patients must accept that they need treatment, they must persist in taking the treatment over time, and they must comply with their prescribed treatment (that is, take the right dose at the right time and with the correct frequency).

Medication adherence is a major concern in the MS population, particularly with DMTs.10,12,13 The WHO estimates an average adherence rate of only 50% among chronically ill patients in the developed world.10,13  Although overall rates of adherence to DMTs in patients with MS is estimated to be higher than 50%,10,12 variations among studies and medications do exist. Suboptimal adherence to DMTs has a negative impact on patient morbidity and mortality outcomes, as well as on overall costs of patient care.1,10 Some of the major benefits associated with patient adherence to therapy are displayed in Figure 2.

Four recent studies have evaluated adherence rates with the first-generation, injectable DMTs (including interferon beta-1b, intramuscular interferon beta-1a, subcutaneous interferon beta-1a, and glatiramer acetate) used in the treatment of MS.13-16
  • In a population-based cohort study of 4830 patients, optimal adherence was observed in 76% of patients after 1 year of therapy.13 Patients who initiated therapy in recent years were more likely to have suboptimal adherence and to discontinue their DMT within the first 12 months versus those who began treatment in earlier years.
  • In a systematic review of medication adherence from 24 studies with a combined population of >2400 patients, 59.6% of patients were adherent to therapy.14 Common barriers to adherence included patients forgetting to their take medication, perceived lack of efficacy, anxiety about injections, and adverse reactions.
  • In a multicenter, observational study of 798 patients, nonadherence was reported by 36% to 39% of patients surveyed.15 Forgetting to administer their injections, which was the most common reason cited by participants for nonadherence, was reported by 58% of those with adherence issues. Other reasons for nonadherence included injection-site reactions, effects on quality of life, and symptoms of depression.
  • Of the 2648 patients evaluated in the Global Adherence Project, 75% were adherent to therapy.16 The most common reported reasons for nonadherence included forgetting to administer the injection and other injection-related reasons.
Adherence is difficult to quantify.10 In many cases, there can be multiple contributing factors to poor adherence versus only one factor. Clinical trial data have identified a myriad of contributing factors that lead to poor adherence, including cognitive impairment, perceived lack of efficacy from DMTs, economic/financial challenges, adverse events (AEs) associated with the agent, and fear/anxiety over using injections.10,11 A number of different approaches might help to improve adherence among patients with MS.
  • Enlist support from family members and/or caregivers.10
  • For patients who experience cognitive impairment and those who frequently forget to take their medication, efforts should be made to simplify treatment regimens.10 Medications that can be administered fewer versus more times per day should be suggested, and monotherapy options rather than combination therapies should be recommended.
  • Establish realistic expectations about the potential benefits of treatment.1,12 Patients should understand that DMTs do not “cure” MS, that they may not eliminate MS symptoms, and that they may not completely eradicate future disease activity.
  • Evaluate the economic burden on patients associated with the use of MS medications.10,11 Providers should have an improved understanding of formulary issues, such as the selection of agents that are available on the formulary, the formulary override process, prior authorization, initiation and ongoing approval, and adherence to Risk Evaluation and Mitigation Strategies (REMS), where needed.5 Additionally, support from a social worker can be helpful, along with enlisting aid from the manufacturer. Medication assistance programs exist for all of the FDA-approved DMTs.


Provide injection training for injectable DMTs.10-12 For example, patients should be trained to rotate injection sites, to use an autoinjector (which is available free of charge from manufacturers), to inject medications at room temperature, to ice the area before and after injecting medication, and to massage the area following injection (for interferon beta products only).

Manage AEs accordingly.10-12 Remind patients using interferon beta agents that flulike symptoms often improve with time, and can be relieved by premedication with nonsteroidal anti-inflammatory drugs or acetaminophen. The impact of flulike symptoms may also be reduced by administering the agent in the evening, before bed, on the weekend, or before another convenient period of time.

For patients who experience poor treatment adherence because of anxiety or fear over administering injections, consider switching to an oral therapy.11

Switching Therapies

Patients who do not respond well to one DMT may need to switch to another DMT.1,3,4,17 Possible markers of nonresponse to treatment include continued, frequent relapses or magnetic resonance imaging findings suggestive of disease activity (such as gadolinium-enhancing activity or new lesion formation).3 Switching therapies also may be necessary for patients who experience intolerable adverse events; however, switching treatments within 6 months of treatment is discouraged, because many adverse events diminish over time.12 Switching medications might also be indicated for patients who have difficulty remaining adherent to therapy, as switching is often an effective method in which to proactively promote medication adherence.11

Timing is also an important consideration when it comes to switching therapy.1,4,18 If patients are experiencing disease progression despite being treated with a DMT, switching should be considered earlier than later, because residual impairment may worsen with each new relapse. It is also important to recognize that switching DMTs may lead to breakthrough disease, particularly with longer-acting products.

Other considerations (besides risks/benefits, which have been discussed previously) when switching therapies include the following: immunogenicity; mechanism of action of prior DMTs, which can affect the efficacy and safety of subsequent therapies; risk for progressive multifocal leukoencephalopathy (PML); and immunization status.1,4 Patients should also be evaluated for active or uncontrolled infections.

The presence of neutralizing antibodies, which is associated with several DMTs (including beta interferon medications and natalizumab), can decrease the effectiveness of an agent and thus can lead to increased disease activity.1,7,19 It is generally not advisable to switch a patient who has developed neutralizing antibodies from one interferon beta agent to another, because he or she will likely also develop neutralizing antibodies from use of the second interferon beta agent.

A transition period between stopping a current DMT and initiating a new DMT may be necessary in some circumstances.4 For example, the immunologic effect of alemtuzumab (which is not related to its half-life) may persist long after the cessation of treatment. This might potentially expose patients to immune-mediated risks when they are switched to other DMTs.

 
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