Currently Viewing:
Newsroom
Currently Reading
Polypharmacy Plays a Role in Patients With Relapsing-Remitting Multiple Sclerosis
February 17, 2019 – Laura Joszt
Review Find Moderate Evidence That Aerobic Exercise Lowers Number of Migraine Days
February 16, 2019 – Jaime Rosenberg
Continuous Fingolimod Treatment Leads to 50% Reduction of ARRs
February 15, 2019 – Samantha DiGrande
CMS Proposes That Patients Be Enrolled in Studies to Get Coverage for CAR T-Cell Therapy
February 15, 2019 – Mary Caffrey and Allison Inserro
What We're Reading: Syphilis Rates Rising; House Democrats and ACA Suit; WHO to Look at Gene Editing
February 15, 2019 – AJMC Staff
HCCI Report: Healthcare Spending Increased Even as Utilization Decreased or Stagnated
February 15, 2019 – Wallace Stephens
AJMC® in the Press, February 15, 2019
February 15, 2019 – AJMC Staff
5 Findings From the February 2019 Issue of AJMC®
February 15, 2019 – Christina Mattina
This Week in Managed Care: February 15, 2019
February 15, 2019

White Matter Lesions Does Not Affect Cortical Thickness or Volume

David Bai, PharmD
Results from a recent study showed that only age affects cortical thickness or volume, and intracranial volume affects cortical volume in migraine.
 
Results from a recent study showed that white matter lesions and clinical migraine characteristics have no effect on cortical thickness and volume of bilateral lobes. Instead, only age affects cortical thickness or volume and only intracranial volume affects cortical volume.

Migraine is a neurological disorder that affects the structure and functional aspects of the cerebral cortex. Some patients with migraine have intracerebral white matter lesions (WMLs) caused from cortical changes because of the migraine attacks. Although WMLs are likely to be microvascular, the effects that they exert on cortical thickness and volume is relatively unknown. In a recent study, investigators assessed patients with migraines with or without WMLs to compare potential cortical thickness and volume differences between them.

During a recruitment period of 7 years, investigators enrolled 161 female patients. Gender similarity was used to exclude any gender-related differences, such as longer headache duration and higher intensity of attacks. Forty healthy patients were also included as a control group. Patients with WMLs were significantly older than patients without WMLs (P = .0003) and patients who were healthy (P = .018). Total number of migraine attacks, disease duration, and rate of aura were also significantly higher in the WMLs group compared with the group without the lesions.

Among the groups, left and right sided lobular and insular volumes and thickness were not significantly different. Cortical thickness and volume for the frontal, parietal, temporal, occipital, and insular were all not statistically different among the 3 groups.

Although the presence of lesions did not significantly affect cortical thickness and volume, patient age did. Age had a significant negative association with both thickness and volume for each of the 5 regions (P < .001). In contrast, intracranial volume had a positive association with cortical volume. Intracranial volume only affected cortical volume, and not thickness (P < .001). There were no significant interactions between group with age, group with intracranial volume, or age with intracranial volume. 

From this female migraine group, investigators found that neither lesions nor any other clinical characteristics affected cortical thickness or volume. For each region, cortical thickness and volume were practically equivalent and within the predefined relevant limit of ±0.1mm. Only age was shown to be a significant predictor of cortical thickness and volume, and intracranial volume for cortical volume.

Reference:

Komáromy H, He M, Perlaki G. Influence of hemispheric white matter lesions and migraine characteristics on cortical thickness and volume. J Headache Pain. 2019;20(1):4. doi: 10.1186/s10194-019-0959-2.

 
Copyright AJMC 2006-2018 Clinical Care Targeted Communications Group, LLC. All Rights Reserved.
x
Welcome the the new and improved AJMC.com, the premier managed market network. Tell us about yourself so that we can serve you better.
Sign Up
×

Sign In

Not a member? Sign up now!