A population-based study found that patients with a preexisting diagnosis of rheumatoid arthritis have a higher risk of developing hidradenitis suppurativa.
A study seeking to evaluate the bidirectional association between hidradenitis suppurativa (HS) and rheumatoid arthritis (RA) found that patients with a history of RA are more susceptible to developing HS, according to results published in Immunologic Research.
The current population-based study enrolled 6779 patients with HS and 33,260 age-, sex- and ethnicity-matched control subjects. Investigators used a case study design to evaluate the prevalence of preexisting RA among patients with HS and identify the odds of RA in individuals with a history of HS, as well as a retrospective cohort design to assess the risk of RA after HS.
Results of the case-controlled design showed the following:
Results of the retrospective cohort design showed the following:
An assessment of the characteristics of patients with HS and comorbid RA relative to the remaining patients with HS elucidated that patients with HS and comorbid RA were significantly older at the onset of HS, had greater Charlson Comorbidity Index scores, and had higher lifetime prevalence of diabetes mellitus, hypertension, and hyperlipidemia.
The risk of all-cause mortality was found to be comparable between the 2 subgroups following an evaluation of all-cause mortality of patients with HS and comorbid RA compared with the remaining patients with HS (HR, 2.59; 95% CI, 0.64-10.47; P = .183).
The findings of the current study should bring awareness to clinicians managing patients with HS and RA about the association between the diseases and their respective symptoms. Treatment methods that have demonstrated positive results for both conditions might be preferred for patients with a dual diagnosis of HS and RA. More research is needed to understand the underlying pathomechanisms of the study’s observations, authors concluded.
Kridin K, Shavit E, Damiani G, Cohen AD. Hidradenitis suppurativa and rheumatoid arthritis: evaluating the bidirectional association. Immunol Res. 2021;69(6):533-540. doi:10.1007/s12026-021-09221-4