John Eikelboom, MD, of McMaster University discusses the 3 outcomes of the COMPASS trial that address the main concerns of patients.
John Eikelboom, MD, of McMaster University discusses the 3 outcomes of the COMPASS trial that address the main concerns of patients.
Transcript (slightly modified)
What specific data set from the COMPASS trial were you most surprised with?
The COMPASS trial results are, of course, exciting, but also some outstanding results, some results that really heighten the imagination. What are the 3 outcomes that my patient says “I just absolutely do not want these outcomes”? Well the first that comes to mind is stroke—42% risk reduction in stroke. Unexpected and I think real, although, there is a play of chance and maybe it was a little bit bigger of a treatment effect than we’d anticipated, but who could imagine that we would reduce the risk of ischemic stroke by almost 50%.
The second outcome that my patients fear is an amputation. I don’t think there’s anybody in the world who does not fear the prospect of amputation. In the COMPASS trial, we saw a reduction by half, by more than half, in the need for amputation.
The third outcome I think my patients don’t want is, by and large, they don’t want to die. It’s very hard to show mortality benefit in any antithrombotic population during long term treatment, but plucking these people of the street with chronic, stable cardiovascular disease and mortality reduction, I would say they are my 3 highlights.
Survival, PROs Favor Cemiplimab Plus Chemotherapy vs Chemotherapy Alone in Advanced NSCLC
December 4th 2023For patients with advanced non–small cell lung cancer (NSCLC), regardless of PD-L1 status, cemiplimab plus chemotherapy had favorable survival benefits and patient-reported outcomes over chemotherapy alone.
Read More
The Importance of Examining and Preventing Atrial Fibrillation
August 29th 2023At this year’s American Society for Preventive Cardiology Congress on CVD Prevention, Emelia J. Benjamin, MD, ScM, delivered the Honorary Fellow Award Lecture, “The Imperative to Focus on the Prevention of Atrial Fibrillation,” as the recipient of this year’s Honorary Fellow of the American Society for Preventive Cardiology award.
Listen
NK Cell Therapy SNK01 Improves Cognitive Function in Alzheimer Disease for up to 11 Weeks
December 3rd 2023Among 10 patients evaluated, compared with their baseline at 1 week after receiving their final dose in the trial, 30% demonstrated clinical improvement on the Alzheimer’s disease composite score.
Read More