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Supplements and Featured Publications, Erectile Disfunction In the Patient with Diabetes Mellitus, Volume 10, Issue 1 Suppl

Continuing Medical Education Accreditation

The University of Cincinnati College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor medical education for physicians.

The University of Cincinnati College of Medicine designates this educational activity for a maximum of 2 hours of Category 1 CME credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours that he/she actually spends in the educational activity.

Continuing Pharmacy Education Accreditation

Pharmacy Times

is approved by the American Council on Pharmaceutical Education as a provider of continuing pharmacy education. This program is approved for 2 contact hours (0.2 CEU) under the ACPE universal program number of 290-000-03-014-H01.


After reading "Erectile Dysfunction in the Patient With Diabetes Mellitus," complete the program evaluation and select the 1 best answer to each of the following questions. A statement of continuing education hours will be mailed to those who successfully complete (a minimum score of 70%) the examination at the conclusion of the program.

1. Which of the following is true regarding the formation of a normal erection?

  • Nitric oxide stimulates the production of cyclic guanosine monophosphate (cGMP).
  • cGMP through changes in intracellular calcium causes a constriction of vascular smooth muscle of the corpora cavernosa.

2. A decreased level of nitric oxide synthase in which of the following cells can lead to erectile dysfunction (ED)?

  • Neuronal
  • a and b

3. Relaxation of vascular smooth muscle of the corpora cavernosa is not facilitated by:

  • Endothelin
  • Vasointestinal peptide

4. Which of the following classes of drugs are likely causes of ED?

  • Angiotensin-converting enzyme inhibitors
  • All of the above

5. Documented beneficial therapy for erectile dysfunction in diabetes mellitus (EDDM) includes all of the following except:

  • Sexual stimulation
  • Interpersonal assertiveness

6. Which of the following hormonal replacement options is not recommended in a patient with androgen-deficiency ED?

  • Intramuscular testosterone
  • Buccal testosterone

7. Which of the following is not a first-line therapy for EDDM?

  • Psychosocial counseling
  • Oral drug therapy

8. Use of a VCD is not limited by:

  • Nitrates
  • Bruising

9. Which of the following oral agents is comparable to the phosphodiesterease type 5 (PDE-5) inhibitors as an effective treatment of EDDM?

  • Yohimbine
  • None of the above

10. Sildenafil is effective in the treatment of EDDM because it:

  • Induces the breakdown of cGMP
  • Delays the breakdown of nitric oxide

11. Which of the following statements concerning PDE-5 inhibitors is/are true?

  • Direct comparison of trials is valid since questionnaires used were similar and interpretation of results was standardized.
  • All of the above are false.

12. Efficacy of PDE-5 inhibitors is dependent on all of the following factors except:

  • Type of diabetes treatment used
  • a and c

13. Which side effect(s) has/have been reported with all 3 PDE-5 inhibitors?

  • Visual disturbances
  • All of the above

14. Which of the following statements is true regarding the pharmacokinetics of PDE-5 inhibitors?

  • Vardenafil has a longer duration of action than either sildenafil or tadalafil.
  • The duration of action of all 3 PDE-5 inhibitors is approximately equal.

15. Unstable angina, ventricular arrhythmias, and congestive heart failure are:

  • Causes of EDDM
  • Contraindications to use of PDE-5 inhibitors

16. Prostaglandin E-1 MUSE is not acceptable for use in which of the following patients?

  • EDDM patients who fail oral PDE-5 inhibitor therapy
  • EDDM patients who refuse intracavernosal injections

17. Candidates for intracavernosal injections include:

  • Patients with sickle cell anemia
  • a and c

18. Patients who do not improve after first- or second-line therapy with pharmacologic therapy are candidates for which of the following third-line options?

  • Penile vein ligation
  • All of the above are effective treatments of EDDM

19. Which of the following statements regarding combination therapy in EDDM patients is true?

  • Using 2 PDE-5 inhibitors together improves effectiveness.
  • b and c

20. When counseling a patient on the use of oral PDE-5 inhibitor therapy, a pharmacist should:

  • Instruct the patient that sildenafil should be used with caution in patients receiving alphablockers.
  • All of the above



For Physicians


For Pharmacists


Testing and Grading Procedures

  • Each participant achieving a passing grade of 70% or higher on any examination will receive an official computer form stating the number of CE credits earned. This form should be safeguarded and may be used as documentation of credits earned.
  • All answers should be recorded on the answer form. Please print clearly to ensure receipt of CE credit.

Pharmacy Times

  • Take the test online with a $5.00 payment at www.pharmacytimes. com and receive immediate grading and CE credits, and download your CE statement of credit.

Please photocopy the test form for additional test takers

Pharmacy Times

is accredited by the American Council on Pharmaceutical Education as a provider of continuing pharmaceutical education. This program is approved for 2 contact hours (0.2 CEUs) under the ACPE universal program number of 290-000-03-014-H01. The program is available for CE credit through January 31, 2007.