
Long-term CPAP Use Linked With Improved Sleepiness, Depressive Symptoms in Patients With OSA
Patients with obstructive sleep apnea (OSA) exhibited improvements in sleepiness, depressive, and anxiety symptoms after 3 years of continuous positive airway pressure therapy (CPAP) use, although higher adherence to CPAP was linked with weight gain.
Use of continuous positive airway pressure therapy (CPAP) among patients with obstructive sleep apnea (OSA) was associated with improvements in sleepiness, depressive, and anxiety symptoms after 3 years, according to study findings published in the
In assessing risk for OSA,
Moreover, patients with OSA have been found to experience adverse quality-of-life symptoms, chiefly
Seeking to better understand the influence of long-term CPAP therapy on mood and sleepiness, as well as factors that may influence weight, researchers conducted a prospective study among patients referred to the Department of Pulmonary Diseases at Turku University Hospital, from March 2004 to October 2006, with symptoms suggesting OSA (N = 223; 54.7% women).
Patients underwent an overnight in-hospital cardiorespiratory polygraphy at baseline and completed a series of questionnaires, including the
Questionnaires were repeated after 3 years among the 149 patients who completed the follow-up, in which a little more than half of participants used CPAP (n = 76).
At baseline, CPAP users were indicated to have more depressive symptoms and higher body mass index and
Among CPAP users, depressive symptoms decreased significantly compared with nonusers (P = .002), with sleepiness (P = .031) and sleep quality (P < .001) shown to improve more in CPAP users than in nonusers. Anxiety was also found to be decreased among the CPAP users, in contrast with nonusers, who reported a slight increase at follow-up.
“This research provides further evidence that long-term CPAP therapy in patients with OSA not only decreases sleepiness and improves sleep quality, but could also alleviate depressive symptoms and anxiety,” said the study authors.
Researchers highlighted that study findings reinforce that CPAP therapy alone is not sufficient for weight management in patients with OSA. “We advise on life-style counseling and weight management program to all patients with obesity on CPAP therapy.”
Reference
Aro MM, Anttalainen U, Polo O, Saaresranta T. Mood, sleepiness, and weight gain after three years on CPAP therapy for sleep apnoea. Eur Clin Respir J. Published online February 17, 2021. doi:10.1080/20018525.2021.1888394
Newsletter
Stay ahead of policy, cost, and value—subscribe to AJMC for expert insights at the intersection of clinical care and health economics.