Gianna is an associate editor of The American Journal of Managed Care® (AJMC®). She has been working on AJMC® since 2019 and has a BA in philosophy and journalism & professional writing from The College of New Jersey.
In patients with idiopathic epiretinal membrane (ERM), membrane contraction contributed to increased choroidal thickness, according to study results published in PLoS One.
In patients with idiopathic epiretinal membrane (ERM), membrane contraction contributed to the increase of choroidal thickness, according to study results published in PLoS ONE.
ERM can induce differing degrees of blurred vision and metamorphopsia (a visual defect that distorts linear objects); in early stages, it is characterized by an abnormal retinal light reflex on fundoscopy with mild retinal thickening and no distortion of the retinal surface, researchers explained.
“However, as the membrane becomes thicker, it may cause retinal folds, excursion, or tortuosity of retinal vessels, resulting in increased retinal thickness, macular edema, and disturbances in macular micro-circulation.”
Several macular diseases, including age-related macular degeneration, have been shown to be associated with changes in choroidal thickness, but no data have been published evaluating the influence of different morphological optical coherent tomography (OCT) findings on choroidal thickness in idiopathic ERM.
To compare the macular choroidal thickness of idiopathic ERM and fellow (healthy) eyes before and after vitrectomy, investigators used spectral-domain OCT (SD-OCT) to assess morphological features.
In the retrospective study, researchers analyzed medical records of patients diagnosed with idiopathic ERM who presented to a hospital in Taiwan between January 2014 and June 2017.
A total of 84 patients presented with unilateral ERM, and all were classified into 3 groups. Patients in group 1 had ERM without membrane contraction (n = 20), those in group 2 had ERM with membrane contraction and associated retinal folding (n = 27), and group 3 (n = 37) consisted of patients who had ERM with membrane contraction and macular edema.
Mean (SD) patient age was 64.9 (9) years, and the majority (56%) were women. There were no statistically significant differences in age, percentage of women, or hypertension among the 3 groups, although individuals in group 1 tended to have better visual acuity than those in groups 2 and 3 (P = .019).
Taken together, researchers claimed the results indicate that membrane contraction contributes to the increase in choroidal thickness in patients with idiopathic ERM.
Small sample sizes and short-term follow-ups mark limitations of the study, and because patients in group 1 had generally good visual acuity, no patients in the group underwent surgery. Researchers therefore could not determine the change in choroidal thickness among patients without macular traction.
To reduce potential bias and confirm results, further studies with larger cohorts of patients are warranted.
Overall, the findings “may help to elucidate the pathophysiologic features of idiopathic ERM as well as the response to treatment in these patients,” authors concluded.
Fang I, Chen L. Association of macular choroidal thickness with optical coherent tomography morphology in patients with idiopathic epiretinal membrane. PLoS One. Published online September 29, 2020. doi:10.1371/journal.pone.0239992