Mortality Following Hip Fracture in Chinese, Japanese, and Filipina Women

The American Journal of Managed CareOctober 2016
Volume 22
Issue 10

One-year mortality following hip fracture in Asian American women is comparable among Chinese, Japanese, and Filipina women, comprising nearly three-fourths of the Asian population examined.

Am J Manag Care. 2016;22(10):e358-e359Take-Away Points

  • Asians are one of the fastest growing racial subgroups within the United States and constitute a relatively heterogeneous population.
  • Asian American women have lower mortality following hip fracture compared with white women, but differences by ethnic origin are unknown.
  • This study demonstrates similarly low 1-year mortality rates following hip fracture among Chinese, Japanese, and Filipina women, who make up nearly three-fourths of the Asian hip fracture population examined.
  • Mortality risk did not differ significantly by ethnic subgroup, even after adjusting for differences in age and comorbidity burden.
  • These findings support further efforts to examine similarities and differences in osteoporosis-related outcomes in larger Asian American populations.

We previously published data from Kaiser Permanente Northern California demonstrating that mortality following hip fracture varied by race/ethnicity, with 1-year mortality rates following hip fracture found to be one-third lower in Asian women (15.6%) compared with white women (23.6%).1 These findings are of interest, given that Asians make up the fastest growing racial subgroup within the United States over the past 10 years.2 Furthermore, according to the 2010 US Census, California contributes 32.1% of the US Asian population.2 Asian Americans, however, form a heterogeneous population of East, South, and Southeast Asians where selected health outcomes may vary substantially,3 and differentiating these minority populations may be important for understanding potential health disparities.

Although previous studies have examined bone mineral density and fracture risk among selected Asian subgroups in California,4-6 the extent to which postfracture health outcomes vary between these ethnic populations has not been examined. In this report, we conducted additional analyses within our prior study1 to describe the distribution of the 3 largest Asian ethnic subgroups among northern Californian women experiencing hip fracture and their corresponding rates of early rehospitalization and 1-year mortality post hip fracture.

Among 615 Asian women who experienced hip fracture between 2000 and 2010,1 we used available ethnic subgroup data to ascertain those of Chinese, Japanese, and Filipina ethnicity and conducted additional chart record validation of ethnicity for all women initially identified as Filipina and for 9% of Chinese and Japanese women with mixed ethnic origin data or inconsistent surnames. These efforts classified 172 (28%) Chinese, 153 (24.9%) Japanese, and 119 (19.4%) Filipina women, accounting for 72.2% (444 of 615) of women with hip fracture identified as Asian.

By ethnic subgroup (Table), Chinese and Japanese women were similar in age, whereas Filipina women were slightly younger and more likely to be younger than 85 years (P <.05) at the time of hip fracture. Filipina women also had greater comorbidity (comorbidity index ≥3; P <.05, as previously classified)1 compared with the other 2 subgroups. Nonsignificant differences in rehospitalization rates within 30 days of hospital discharge were noted, with a possible trend toward lower rates of early rehospitalization among Japanese women (P = .06) versus Filipina. One-year overall mortality rates following hip fracture were similar (Chinese: 14.0%; Japanese: 15.0%; and Filipina: 14.3%), and mortality risk did not differ significantly by group when adjusted for age, comorbidity, fracture type, and history of fracture.

In summary, the low 1-year mortality rate among Asian women following hip fracture was reflected similarly across the 3 Asian subgroups in the same healthcare setting, accounting for nearly three-fourths of the Asian hip fracture cohort. Although the number of women in each subgroup was relatively small, thus limiting the generalizability of our conclusions, this is one of the first studies to classify ethnic origin among US Asians experiencing hip fracture and their subsequent morbidity and mortality outcome. Future studies should be conducted in larger, diverse US populations of Asian race to determine the extent to which Asian ethnic subgroups vary with regard to key osteoporosis-related health outcomes.Author Affiliations: Department of Medicine (MCP, JCL), Kaiser Permanente Oakland Medical Center; Division of Research (MC, JCL), Kaiser Permanente Northern California, Oakland CA.

Source of Funding: None.

Author Disclosures: Drs Lo and Chandra have received past research funding from Amgen and Dr Lo has received current research funding from Sanofi, unrelated to the current study. Dr Patel reports no relationship or financial interest with any entity that would pose a conflict of interest with the subject matter of this article.

Authorship Information: Concept and design (MCP, JCL), acquisition of data (MCP, MC, JCL), analysis and interpretation of data (MCP, MC, JCL); drafting of the manuscript (MCP, JCL), critical revision of the manuscript for important intellectual content (MCP, MC, JCL); and statistical analysis (MC).

Address Correspondence to: Joan C. Lo, MD, Kaiser Permanente Northern California Division of Research, 2000 Broadway, Oakland, CA 94612. E-mail:

1. Lo JC, Srinivasan S, Chandra M, et al. Trends in mortality following hip fracture in older women. Am J Manag Care. 2015;21(3):e206-e214.

2. Hoeffel EM, Rastogi S, Kim MO, Shahid H. The Asian population: 2010. US Census Bureau website. Published March 2012. Accessed September 28, 2016.

3. Dumbauld S, McCullough JA, Sutocky JW. Analysis of Health Indicators for California’s Minority Populations. Collingdale, PA: Diane Publishing Company; 1994.

4. Khandelwal S, Chandra M, Lo JC. Clinical characteristics, bone mineral density and non-vertebral osteoporotic fracture outcomes among post-menopausal U.S. South Asian women. Bone. 2012;51(6):1025-1028. doi: 10.1016/j.bone.2012.08.118.

5. Morton DJ, Barrett-Connor E, Kritz-Silverstein D, Wingard DL, Schneider DL. Bone mineral density in postmenopausal Caucasian, Filipina, and Hispanic women. Int J Epidemiol. 2003;32(1):150-156.

6. Kin K, Lee JH, Kushida K, et al. Bone density and body composition on the Pacific rim: a comparison between Japan-born and U.S.-born Japanese-American women. J Bone Miner Res. 1993;8(7):861-869.

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