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Precision Medicine, the Oncology Care Model, and PD-1s
The third segment of The Clinical and Reimbursement Landscape of Immuno-Oncology series, focusing on the new PD-1 agents, addressed personalized or precision medicine and CMMI’s new Oncology Care Model. Dr Kolodziej, an Aetna national medical director of oncology strategy, believes that precision medicine is not a perfect fit for the new model, but at least partially it can be paid for through “innovation” payments. He points out that precision medicine should not evolve greatly within the timeframe of the Oncology Care Model (3-5 yr), so it should not have a great deal of effect on the success of the model.
The PD-1 class, although very much part of the precision medicine treatment concept, “which kind of throws it all on its head,” says Dr Feinberg, Cardinal Health Specialty Solutions vice president and chief medical officer. Instead of identifying unique molecular and genetic phenomenon occurring in individual tumors, PD-1s may be active against “half or two-thirds of all malignancies,” not a tiny proportion of a population with a particular cancer.
Dr Feinberg emphasizes that the mechanism of action of PD-1 agents to abort tumor growth applies to a majority of tumor types. He comments, “It’s personalized, precision medicine that may be precision for everyone.”
Navigating Health Policy in an Election Year: Insights From Dr Dennis Scanlon
April 2nd 2024On this episode of Managed Care Cast, we're talking with Dennis Scanlon, PhD, the editor in chief of The American Journal of Accountable Care®, about prior authorization, price transparency, the impact of health policy on the upcoming election, and more.
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Data Back Neoadjuvant Combo vs Chemo Alone for Early-Stage NSCLC
April 24th 2024For patients with early-stage non–small cell lung cancer (NSCLC), combining neoadjuvant immune checkpoint inhibitors and platinum-based chemotherapy improves 2-year outcomes over chemotherapy alone, suggest findings of an extensive literature review and meta-analysis.
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Navigating Health Literacy, Social Determinants, and Discrimination in National Health Plans
February 13th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the February 2024 issue of The American Journal of Managed Care® about their findings on how health plans can screen for health literacy, social determinants of health, and perceived health care discrimination.
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Downward Morbidity, Mortality Trends Discovered Among Patients With Ovarian Cancer, Liver Metastases
April 24th 2024This study indicates a declining trend in morbidity and mortality rates among patients with ovarian cancer and liver metastases, highlighting the efficacy of surgery and chemotherapy in improving survival outcomes.
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The Federal Trade Commission's (FTC's) vote to ban most employers from issuing and enforcing noncompete clauses could have varying impacts on the health care workforce; federal regulators vastly under-enforced antitrust laws in the hospital sector during the last 2 decades, resulting in increased health costs; the FDA recently found genetic evidence of the H5N1 bird flu virus in pasteurized commercially purchased milk.
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