The Economic Impact of OFF Periods in Parkinson Disease

October 13, 2020

ABSTRACT

Parkinson disease affects nearly 1 million people in the United States, and the prevalence is expected to increase to at least 1.2 million people by 2030. Parkinson disease is a chronic, incurable disease. Most treatments focus on controlling motor symptoms; however, as the disease progresses, periods of reduced therapeutic benefit, or OFF periods, become more frequent and increasingly troublesome. OFF periods contribute to the already substantial economic burden of Parkinson disease. People with Parkinson disease who experience OFF periods and their caregivers have reported more work days with low productivity and more missed work days compared with those who do not experience OFF periods. More caregivers of people with Parkinson disease who experience OFF episodes reported that due to the disease, they had reduced or changed working hours, lost opportunities, or had reduced work productivity, and these caregivers reported an average of more than twice the amount of employment income lost compared with caregivers of people with Parkinson disease who do not experience OFF periods.

Am J Manag Care. 2020;26:S265-S269. https://doi.org/10.37765/ajmc.2020.88518

For author information and disclosures, see end of text.

Introduction

Parkinson disease (PD) is the second-most-common neurodegenerative disease in the world,1 expected to affect at least 1.2 million people in the United States by 2030.2 An incurable, chronic disease, its economic impact can be substantial for people with Parkinson disease (PwP) and their caregivers. All PwP experience a characteristic motor syndrome of bradykinesia, resting tremor, muscle rigidity with associated gait disorder, and postural instability.1 Most patients also experience 1 or more nonmotor symptoms, including autonomic dysfunction, sleep disorders, mood disorders, bowel and/or bladder dysfunction, and cognitive abnormalities.3,4 The motor symptoms of PD can be decreased or ameliorated by symptomatic therapies, but as the disease progresses, response to therapy declines, and patients experience periods with reduced or absent symptomatic benefit, despite optimized therapeutic dosing; these are termed OFF episodes.5 No formal definition of OFF exists; however, Chou and colleagues proposed a multifactorial, practical definition of OFF, which includes a change in patients during which nonmotor and motor symptoms appear or worsen (Table).5

Few studies have evaluated the economic impact of OFF episodes for patients and their caregivers; however, the results of recent studies are explored herein.

Epidemiology of Parkinson Disease

PD is a disorder of mid- to late-life; incidence and prevalence rise with increasing age.1 The prevalence of PD in individuals older than 50 years is expected to more than double between 2005 and 2030 in the most populous nations, reflecting the aging of the global population.6 Other factors, such as genetics and changes in environmental risk, may further contribute to increased incidence and prevalence in the future.7,8 The incidence of PD is twice as common in men than in women in most populations.1 Applying both sex- and age-specific estimates to the US population as reported in the US Census, there were an estimated 680,000 cases of PD among individuals 45 years or older in 2010. Presuming stable sex- and age-specific prevalence, an increase to 930,000 cases is estimated to occur in 2020, with a further increase to 1.2 million cases projected by 2030.2

Current Pharmacological Treatments for Parkinson Disease

Pharmacotherapies that are currently available for PD treat only the symptoms of the disease; no drug has been proven to slow or halt disease progression. As the disease progresses, polypharmaceutical approaches are common, and many patients take combinations of dopaminergic agents that target the motor symptoms of the disease, as well as other drugs for nonmotor symptoms.1 Surgical therapies can also effectively treat the motor symptoms of the disease9;however, for the purpose of this manuscript, only drugs will be discussed.

Complications of Therapy: ON-OFF Periods

After 50 years of use, levodopa, the precursor to dopamine, remains the first-line and most effective oral agent (in combination with carbidopa) for managing the motor symptoms of PD.1 Early in the course of the disease, relatively infrequent levodopa dosing is associated with sustained motor benefit. Because the half-life of carbidopa/levodopa is short (about 3 hours), this sustained benefit is thought to reflect sustained central activity.10 As the disease progresses, the magnitude of benefit and the duration of response to a levodopa dose are reduced. Patients experience fluctuations in their response to therapy: Periods of good motor benefit alternate with periods of reduced motor benefit (OFF episodes). Increasing the amount of a single dose of therapy as well as more frequent dosing may temporarily provide a more sustained benefit, but can be complicated by levodopa-induced dyskinesias. Ultimately, OFF episodes return despite optimal dosing, and motor fluctuations often occur regularly over a cycle corresponding to the short plasma half-life of levodopa.5,10

In addition to altered central dopaminergic function due to progressive neurodegeneration, oropharyngeal and enteric nervous system dysfunction—with consequent dysphagia and delayed gastric emptying—can further complicate oral therapy, making response to a single dose unpredictable, often resulting in severe OFF periods or complete dose failure.5,10,11 OFF episodes are not rare: Approximately 50% of PwP experience OFF episodes within 2 years of oral levodopa treatment, nearly 70% experience OFF periods after 9 years of therapy, and essentially 100% experience OFF periods following 20 years of therapy.12,13 The effective management of OFF episodes remains a major challenge, especially as these episodes are associated with poor quality of life in patients who experience them.14

Economic Burden of Parkinson Disease

Despite the major impact of the disease on patients and their care partners, few studies have explored the economic burden of PD. The additional costs of lost income or reduced productivity for PwP and individuals involved in their care have rarely been assessed. To our knowledge, the specific relationship between OFF episodes and the economic burden of PD has not been fully studied.

In 2019, the Michael J. Fox Foundation (MJFF) and the Parkinson’s Foundation commissioned the Lewin Group to perform a comprehensive assessment of the economic impact of PD from a societal perspective, in order to gain a better understanding of the economic consequences of an increasing population of PwP in the United States to better inform health care utilization decision making.15

For the prevalence-based study, Yang and colleagues utilized data from multiple sources, including the Medical Expenditure Panel Survey (MEPS), Medicare Current Beneficiary Survey (MCBS), de-identified Optum Normative Health Information data, and Medicare Standard Analytical File claims data, US Census Bureau population projections, and Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiological Research to estimate the medical (both direct and indirect) and nonmedical costs of PD in the United States.15 The results of an original electronic primary survey completed by participants in Fox Insight, an MJFF for Parkinson’s Research study, and the Unified Parkinson’s Advocacy Council also were utilized to further understand the indirect costs of PD. Data from the MCBS and MEPS were used to estimate the prevalence of the disease.15

Based on an estimated US population of 1.04 million PwP, the total economic burden of PD was estimated to be nearly $52 billion in 2017.15 This total was composed of $25.4 billion in direct medical costs and $26.5 billion in indirect and nonmedical costs (including lost future earnings due to premature death, reduced employment, disease-related motor vehicle and home modification, nonmedical care paid daily, and other costs).15 For comparison, total costs for Alzheimer disease were estimated to be $259 billion in 2017 (based on a population of ~5.5 million individuals with the disease).16

More than $6.5 billion of the indirect and nonmedical costs were due to reduced employment, reduced productivity, and absenteeism of unpaid care partners of PwP.15 In 2017, excess direct medical costs for patients were, on average, $24,439 higher than costs for a person of similar age, sex, and race/ethnicity without PD, with similar insurance. Total average estimated indirect and nonmedical costs per patient were $25,558; this total includes combined losses from PwP and up to 2 caregivers (unpaid primary and/or secondary).15

The personal and societal economic burdens associated with PD were found to be much higher than those found in prior reports, likely reflecting, at least in part, the more extensive assessment of indirect and nonmedical costs identified by the patients who were surveyed. Estimated earnings losses associated with reduced employment of PwP and their caregivers due to PD was $1.87 billion and $802 million, respectively. Absenteeism amounted to annual losses of $1.4 billion and $3.7 billion for PwP and their primary caregivers, respectively.15 Using average earnings data collected from the Fox Insight electronic primary survey, the investigators estimated annual earnings lost due to presenteeism to be $1.3 billion for PwP and $1.7 billion for their caregivers. Lost earnings as a result of premature death in PwP were estimated at $2.5 billion annually overall and $2418
per PwP per year.15 Of all indirect costs estimated in the study for both PwP and their caregivers combined ($14.2 billion), the combined PwP and caregiver absenteeism costs provided the largest cost contribution at $5.1 billion, followed by presenteeism ($2.9 billion) and earnings losses related to reduced employment ($2.7 billion).15

These findings are likely underestimates of the true economic burden of PD. Patients who have not received a diagnosis, those without health insurance, and those in insurance plans that do not report individual costs by diagnosis are not completely represented.15 Additional indirect and nonmedical costs may not have been captured. Nonetheless, these findings provide important new insights into the total economic burden of PD, and they provide an excellent starting point for future studies, including the investigation of the (nonmedical) economic impact of OFF episodes in PwP.

Nonmedical Economic Burden of OFF Periods

Up to 100% of PwP will develop OFF periods at some point during their disease process.12,13 Patients who experience OFF periods also experience multiple stressors related to decreased ability or inability to work, increased dependence on caregivers, and increased health care needs. In a cross-sectional study by Stocchi and colleagues, conducted in Italian movement disorders centers, wearing-off episodes were identified in nearly 42% of PwP with early-stage disease (<2.5 years since diagnosis), and particularly in this stage, episodes of wearing off were underestimated by clinicians.14

To better understand the economic impact of OFF periods on employment in PwP, Abeynayake and colleagues utilized data from the Financial and Social Impact of Parkinson’s Disease Survey commissioned by the Michael J. Fox Foundation and the Parkinson’s Foundation. Study results taken from responses compiled between September 17, 2018, and October 8, 2018, indicated that among 4548 survey respondents (68.1% PwP; 27.8% care partners of PwP; 4.0% family members; 0.01% close friends) more than half (65.4%; n = 2976) reported that the PwP experienced OFF periods in the past 12 months. In comparison, 26.5% (n = 1204) stated the PwP did not experience OFF periods, and 8.1% (n = 368) either had no response or stated that they did not know if the PwP experienced OFF periods. Of the PwP respondents who reported experiencing OFF periods, 19.0% reported working full- or part-time compared with 22.2% of PwP respondents who reported that they did not experience OFF periods. Among care partners of PwP who experienced OFF periods, 42.2% were employed, compared with 33.2% of caregivers for PwP who did not experience OFF periods.17

A total of 51.7% of employed PwP who reported experiencing OFF periods (n = 724) stated they averaged at least 10 days with low productivity each month, compared with 35.2% of employed PwP who reported not experiencing OFF periods (n = 315); 31.9% of employed PwP who reported experiencing OFF periods stated they averaged at least 20 days of low productivity, versus 20.3% of PwP who reported not experiencing OFF periods. Almost one-third (30.4%) of PwP who experienced OFF periods reported missing at least 5 workdays per month due to PD compared with 15.6% of PwP who did not experience OFF periods (Figure 1).17

Using data from the same survey and same time period, Abeynayake and colleagues then sought to characterize the financial burden specific to caregivers of PwP who experience OFF periods. Among the 4548 respondents who completed the survey and were included in the analysis, 65.4% reported that the PwP experienced OFF periods, 26.5% reported that the PwP did not experience OFF periods, and 8.1% were unsure.18

The average duration of disease for patients who reported OFF periods was longer than for those who did not report OFF periods (8.2 years [SD, 6.4] vs 5.6 years [SD, 5.9], respectively). More PwP who experienced OFF periods had a primary caregiver compared with those who did not report OFF periods (69.3% vs 54.3%, respectively), and a secondary caregiver was reported for 23.5% of PwP who experienced OFF periods, compared with 11.8% of those who did not experience OFF periods. Primary and secondary caregivers reported caring for PwP with OFF periods for 38.2 (unpaid) hours each week compared with 28.2 hours for PwP without OFF periods.18

Among caregivers of PwP with OFF periods, 27.5% said that PD had a major role in the decision to stop working, whereas 16.6% of caregivers of PwP without OFF periods reported that the disease played a major role in their decision to stop working. Reduced or changed working hours, lost opportunities, or the inability to keep a job for reasons related to PD were reported by 41.7% of caregivers of PwP who reported that the PwP experienced OFF periods compared with 30.2% of caregivers of PwP without OFF periods. More caregivers of PwP who experienced OFF periods (n = 1868) had a loss in annual income than caregivers of PwP who did not experience OFF periods (n = 564) (Figure 2).18

These findings align with current understanding of the effects of OFF periods, which are inevitable for most PwP. The data from these studies indicate that PwP who experience OFF periods, as well as their caregivers, are likely incurring higher indirect costs, in the form of losses of earnings, employment, and opportunities, as well as decreased productivity, which in turn increases the societal-level economic burden.

Conclusions

Current treatment approaches do not ameliorate OFF episodes in most patients. Effective management of OFF periods is an unmet need with personal and societal implications. Ultimately, improved treatment of OFF episodes may contribute to increased work productivity, decreased burden on caregivers, and fewer dollars lost due to PD. 

Funding Source: Financial support for this work was provided by Acorda Therapeutics.

Author Affiliations: Iresha Abeynayake, Acorda Therapeutics, Ardsley, NY; Caroline Tanner, UCSF Weill Institute for Neurosciences, University of California, San Francisco.

Author Disclosures: Ms Abeynayake was employed by and owned stock in Acorda Therapeutics at the time of the study. Ms Abeynayake reports financial interest or financial conflict with Acorda Therapeutics due to them marketing a drug for Parkinson OFF periods.

Dr Tanner is an employee of the University of California – San Francisco, and the San Francisco Veterans Affairs Health Care System. She receives grants from the Michael J. Fox Foundation, the Parkinson’s Foundation, the Department of Defense, BioElectron, Roche/Genentech, Biogen Idec, and the National Institutes of Health; compensation for serving on data monitoring committees from Voyager Therapeutics, Intec Pharma, and Cadent Therapeutics; and personal fees for consulting from Neurocrine Biosciences, Adamas Therapeutics, Grey Matter, Acorda Therapeutics, Acadia, Amneal, and CNS Ratings

Authorship information: Concept and design (IA,CMT), acquisition of data (IA), analysis and interpretation of data (IA), drafting of the manuscript (IA, CMT), critical revision of the manuscript for important intellectual content (IA, CMT).

Address correspondence to: Iresha Abeynayake, MPH, 9 Zamrok Way, Morristown, NJ 07960. Email: Iresha_abey@yahoo.com.

REFERENCES

1. Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nat Rev Dis Primers. 2017;3:17013. doi:10.1038/nrdp.2017.13

2. Marras C, Beck JC, Bower JH, et al; Parkinson’s Foundation P4 Group. Prevalence of Parkinson’s disease across North America. NPJ Parkinsons Dis. 2018;4:21. doi:10.1038/s41531-018-0058-0

3. Goetz CG, Tilley BC, Shaftman SR, et al; Movement Disorder Society UPDRS Revision Task Force. Movement Disorder Society–sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129-2170. doi:10.1002/mds.22340

4. Sung VW, Nicholas AP. Nonmotor symptoms in Parkinson’s disease: expanding the view of Parkinson’s disease beyond a pure motor, pure dopaminergic problem. Neurol Clin. 2013;31(suppl 3):S1-S16. doi:10.1016/j.ncl.2013.04.013

5. Chou KL, Stacy M, Simuni T, et al. The spectrum of “off” in Parkinson’s disease: what have we learned over 40 years? Parkinsonism Relat Disord. 2018;51:9-16. doi:10.1016/j.parkreldis.2018.02.001

6. Dorsey ER, Constantinescu R, Thompson JP, et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology. 2007;68(5):384-386. doi:10.1212/01.wnl.0000247740.47667.03

7. Simon DK, Tanner CM, Brundin P. Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clin Geriatr Med. 2020;36(1):1-12. doi:10.1016/j.cger.2019.08.002

8. Racette BA, Searles Nielsen S, Criswell SR, et al. Dose-dependent progression of parkinsonism in manganese-exposed welders. Neurology. 2017;88(4):344-351. doi:10.1212/WNL.0000000000003533

9. Okun MS. Deep-brain stimulation for Parkinson’s disease. N Engl J Med. 2012;367(16):1529-1538. doi:10.1056/NEJMct1208070

10. LeWitt PA. Levodopa therapy for Parkinson’s disease: pharmacokinetics and pharmacodynamics.
Mov Disord. 2015;30(1):64-72. doi:10.1002/mds.26082

11. Fasano A, Visanji NP, Liu LWC, et al. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol. 2015;14(6):625-639. doi:10.1016/S1474-4422(15)00007-1

12. Ahlskog JE, Muenter MD. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord. 2001;16(3):448-458. doi:10.1002/mds.1090

13. Hely MA, Reid WGJ, Adena MA, et al. The Sydney multicenter study of Parkinson’s disease: the inevitability of dementia at 20 years. Mov Disord. 2008;23(6):837-844. doi:10.1002/mds.21956

14. Stocchi F, Antonini A, Barone P, et al; DEEP study group. Early DEtection of wEaring off in Parkinson disease: the DEEP study. Parkinsonism Relat Disord. 2014;20(2):204-211. doi:10.1016/j.parkreldis.2013.10.027

15. Yang G, Schmiel L, Zhou M, et al. Economic burden and future impact of Parkinson’s disease: final report. Michael J. Fox Foundation. July 5, 2019. Accessed September 30, 2020. https://www.michaeljfox.org/sites/default/files/media/document/2019%20Parkinson%27s%20Economic%20Burden%20Study%20-%20FINAL.pdf

16. Alzheimer’s Association. 2017 Alzheimer’s disease facts and figures. Alzheimers Dement. 2017;13(4):325-373. doi:10.1016/j.jalz.2017.02.001

17. Abeynayake I, Marinucci LN, Klingler M, Kenney C. Impact of OFF periods on aspects of employment for people with Parkinson’s disease. J Manag Care Pharm. 2019;25(suppl 10a; abstr G9). Accessed September 30, 2020. https://www.jmcp.org/doi/pdf/10.18553/jmcp.2019.25.10-a.s1

18. Abeynayake I, Klingler M, Kenney C. The financial burden of Parkinson’s disease is greater for caregivers of people experiencing OFF periods. J Manag Care Pharm. 2019;25(suppl 10a; abstr C38). Accessed September 30, 2020. https://www.jmcp.org/doi/pdf/10.18553/jmcp.2019.25.10-a.s1