Thiazolidinediones Stimulate the Brain of T2DM Patients to Eat More, Study Finds

The study found that thiazolidinediones, commonly used to treat individuals suffering from type 2 diabetes, activate the PPARY' receptors in the hypothalamus, which in turn triggers food hoarding, food intake.

Medication used to treat patients with type 2 diabetes activates sensors on brain cells that increase hunger, causing people taking this drug to gain more body fat, according to researchers at Georgia State University, Oregon Health and Science University, Georgia Regents University and Charlie Norwood Veterans Administration Medical Center.

The study, published on March 18 in The Journal of Neuroscience, describes a new way to affect hunger in the brain and helps to explain why people taking a class of drugs for type 2 diabetes gain more body fat. Type 2 diabetes, the most common form of diabetes, affects 95% of diabetes sufferers. People with type 1 or type 2 diabetes have too much glucose, or sugar, in their blood. Type 2 diabetes develops most often in middle-aged and older adults and people who are overweight and inactive, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

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