Treating HIV Comorbidities in the Fight to End the Epidemic
HIV-positive individuals face greater risks of kidney and liver diseases, cardiovascular events, osteoporosis, hepatitis C, and cancer. Clinical trials and research advances into the cause and development of the comorbid conditions are needed.
Preventing the spread of new HIV infections was in the
This means, however, that when 2030 arrives, there will still be 1 million people living with HIV in the United States, wrote researchers from the National Institutes of Health in a recent issue of
Some of these conditions are kidney disease, cancer, liver disease, cardiovascular events, and osteoporosis/fractures. Using 2003-2013 data, the authors were able to show higher occurrences of these conditions in persons with HIV taking ART compared with an HIV-negative control group:
- Kidney disease: 8.8% vs 2.8%
- Cancer: 8.0% vs 4.1%
- Liver disease: 6.2% vs 2.4%
- Cardiovascular events: 6.7% vs 4.0%
- Osteoporosis/fracture: 7.6% vs 6.4%
Another critical area to examine is neurocognitive disorders. Yes, effective treatments have led to a decreased prevalence of HIV-associated dementia; however, impairment persists even when the viral load is suppressed to an undetectable level, and the reasons for that remain unclear, the authors pointed out.
What can be done? They suggest more clinical trials and research advances into the cause and development of the comorbid conditions, as well as efforts to reduce healthcare disparities.
For example, the
“Establishing a better understanding of these comorbidities and how to manage them will be essential to reduce the burden these conditions place on individuals and the health care system,” the authors concluded.
Reference
Lerner AM, Eisinger RW, Fauci AS. Comorbidities in persons with HIV: the lingering challenge [published online December 11, 2019]. JAMA. doi: 10.1001/jama.2019.19775. Accessed December 12, 2019.
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