Trial Results Associate Depression With Increased Mortality Risk

The results of an ongoing study, presented at the annual meeting of the Heart Failure Association of the European Society of Cardiology in Seville, Spain, identified a 5-fold increased risk of death in heart failure patients who were depressed.

OPERA-HF, an ongoing observational study enrolling patients hospitalized with heart failure, found that moderate to severe depression is associated with a 5-fold increased risk of all cause mortality in patients with heart failure. The results from OPERA-HF show that risk was independent of comorbidities and severity of heart failure, and patients who were not depressed had a significantly lower risk of death.

In a statement, professor John Cleland, chief investigator of OPERA-HF and professor of cardiology at Imperial College London and the University of Hull, UK, said: "Patients with heart failure are at high risk of recurrent hospital admissions and death. Approximately 25% of patients admitted to hospital with heart failure are readmitted for a variety of reasons within 1 month. Within one year, most patients will have had 1 or more readmissions and almost half will have died."

Original article on ScienceDaily: