David Bai

Articles

Calcaneal Quantitative Ultrasound May Serve as a Prescreening Tool for Osteoporosis

November 03, 2018

Calcaneal quantitative ultrasound (QUS) has comparable diagnostic accuracy as dual-energy x-ray absorptiometry (DXA), the gold standard for diagnosing osteoporosis. Although it cannot replace DXA for diagnosing osteoporosis, it can be used as an effective prescreening tool prior to a DXA scan, researchers said it a recent study comparing the performance of the 2 screening methods.

Flavorants and Propylene Glycol From e-Cigarettes Form Harmful Irritants When Combined

November 02, 2018

The mixture of flavorants and propylene glycol (PG) in electronic cigarettes (e-cigs) leads to the formation of acetals that have been shown to activate irritation receptors, predisposing users to the same potential dangers as using traditional cigarettes, a new study said.

Does Transcriptional Loss of HLA Cause Immunotherapy Resistance?

October 08, 2018

The development of resistance to immunotherapy is poorly understood and is detrimental to patients who relapse on multiple lines of treatment. Transcriptional downregulation of class 1 human leukocyte antigen (HLA) may contribute to the developed resistance of immunotherapies, including checkpoint inhibitors, and warrants further investigation, according to a study published in Nature Communications.

Ipilimumab Plus Nivolumab Improved Tumor Responses in Recurrent Ovarian Cancer

September 28, 2018

A phase 2 trial evaluating the 2 checkpoint inhibitors, nivolumab and ipilimumab, found significantly better tumor responses with the combination compared with nivolumab alone in patients with recurrent epithelial ovarian cancer.

MS-SMART: First Multiarm Efficacy Trial in Progressive MS

September 20, 2018

The Multiple Sclerosis-Secondary Progressive Multi-Arm Randomization Trial (MS-SMART) is the first multiarm trial designed specifically to address the unmet need for further identification of neuroprotective drugs in secondary progressive multiple sclerosis.

Epigenomic Analysis Uncovers Link Between Rheumatoid Arthritis and Huntington Disease

September 19, 2018

In their study published in Nature Communications, the authors mapped out the epigenomic profiles of rheumatoid arthritis (RA) and osteoarthritis for the first time to provide insight on RA-specific pathways and transcription factor motifs. A surprising discovery was that the Huntingtin-interacting protein-1 may play a role in the pathogenesis of RA.