The Long-term Social Value of Granulocyte Colony-Stimulating Factors

October 4th 2019, 5:00pm


Although currently underutilized, granulocyte colony-stimulating factor prophylaxis as supportive cancer care provides substantial value to society. Aligning utilization with clinical guidelines would increase this value considerably.

The Conundrum Of Antibacterial Use in Neutropenic Patients Undergoing Chemotherapy for Hematologic Malignancy or HSCT

April 15th 2019, 8:33pm


Patients with hematologic malignancy who are undergoing chemotherapy or a conditioning regimen for hematopoietic stem cell transplant (HSCT) are at high risk of infection because of the severity and duration of neutropenia. Fever with neutropenia is a common presentation that suggests an infection leading to empiric antibacterial therapy. To prevent infection and thus the neutropenic fever, antibacterial prophylaxis, especially with fluoroquinolones, emerged as a common practice based on results of 2 randomized controlled trials published in 2005 that showed reduced incidence of fever and bacteremia despite lack of a mortality benefit.

Neutropenia Etiology Influences Resulting Hematologic Consequences

March 2nd 2019, 3:06am


Hematological consequences of severe chronic neutropenia vary based on the underlying etiology of the condition, according to a study abstract presented at the 60th American Society of Hematology Annual Meeting & Exposition.

Patients With mCRPC Have Lower Risk of Severe Neutropenia

February 27th 2019, 3:34am


Patients with metastatic castration-resistant prostate cancer (mCRPC) have a lower risk of developing grade 3 or 4 neutropenia, likely due to less exposure to docetaxel.

Home Monitoring Device for Blood Cell, Neutrophil Counts Shows Positive Initial Results

February 22nd 2019, 3:16am


Initial results of a study have found that white blood cell counts and absolute neutrophil counts, which are well-established predictors of risk of infections or febrile neutropenia, can be accurately measured with a finger stick drop of blood and point-of-care hematology results.

Multiday Corticosteroid Administration Delays Diagnosis, Treatment of Febrile Neutropenia

February 19th 2019, 10:32pm


Researchers have found that multiday corticosteroid administration during chemotherapy delays the diagnosis of and antimicrobial administration for febrile neutropenia.

Researchers Characterize Epidemiology of, Source of Infection in Febrile Neutropenia

February 16th 2019, 8:00pm


Researchers have determined that febrile neutropenia has a low rate of bacteremia and approximately half of patients receive the recommended initial empiric therapy.

D-Index–Guided Therapy Reduces Use of Antifungals Without Increasing Infection, Mortality in Febrile Neutropenia

February 14th 2019, 3:08am


A study has demonstrated that D-index–guided early antifungal therapy, a novel approach to treating persistent or recurrent febrile neutropenia, is feasible in high-risk patients with neutropenia.

Continuous Temperature-Monitoring Skin Patch Effective for Detecting Febrile Neutropenia Earlier

February 8th 2019, 10:14pm


According to a study abstract presented at the 60th American Society of Hematology Annual Meeting & Exposition, using a skin patch for continuous temperature monitoring is feasible in the inpatient setting and has the potential to detect febrile neutropenia earlier.

On-Body Injector as Effective as Manual Injection of Pegfilgrastim for Preventing Febrile Neutropenia

February 3rd 2019, 3:24am


In 2015, the Neulasta On-Body Injector (OBI) Onpro device was introduced as a less costly method of pegfilgrastim administration. While the device has been found to be safe in healthy volunteers and have pharmacokinetics similar to that of traditional pegfilgrastim, there have been limited data comparing the 2 methods.