Jaime Rosenberg


Repurposing a Drug Used for Alcohol Abuse May Overcome MM Treatment Resistance

May 15, 2022

According to recent findings, metabolizing disulfiram into diethyldithiocarbamate-copper complex creates a proteasome inhibitor-like treatment that enables the efficient killing of treatment-resistant multiple myeloma (MM) cells.

Researchers Call for Push to More Holistic, Collaborative Care for Young Adults With T1D

May 14, 2022

The group noted that this transformation should affect changes at every level, including at the individual level during patient visits, at the organization level in how clinical encounters are organized, and at the national level in both policies and guidelines for type 1 diabetes (T1D).

Pressure-Induced Increase in PD-L1 Expression May Dull Effect of CAR T-Cell Therapy

May 10, 2022

The study of constructed αROR1‐CAR T cells showed an increase of PD-L1 expression when exposed to elevated pressure, driving resistance to CAR T cell-mediated cytotoxicity. However, the findings also suggest that adding PD-1/PD-L1 inhibitors to CAR T-cell therapy could help address this.