Jaime Rosenberg

The study suggests that adding a Bruton tyrosine kinase inhibitor (BTKi) to frontline chemoimmunotherapy in Richter transformation improved complete response rates and progression-free survival compared with chemoimmunotherapy alone, though overall survival benefits remained unclear.

Recognition of the association between breast implants and lymphomas has been notable since the 1990s, although the association has been limited to breast implant–associated anaplastic large cell lymphoma and not Epstein-Barr virus (EBV).

The researchers emphasized the importance of early referral for chimeric antigen receptor (CAR) T-cell treatment, as patients eligible for the treatment are often in very late stages of disease, and mitigating delays in care has the potential to improve response rates by more than 10%.

The study adds to a growing amount of literature documenting the impact of psoriasis on mental health.

Called the TRIO comprehensive, integrated patient data repository (TRIO CIPDR), the unique registry combines clinical data from electronic health records with pharmacy data, including PAH-specific drugs prescribed, as well as the dates prescribed, administered, and refilled.

The researchers noted that their paper is the first, to their knowledge, to report on a case of thrombocytopenic purpura (TTP) in a patient with metastatic renal cell carcinoma (RCC).

The retrospective study of patient hospital data showed that current approaches to identifying a culprit drug often overidentify drugs unlikely to be responsible for Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) while potentially missing the actual culprit.

When used in conjunction with other risk factors, the 6 distinct blood pressure patterns were able to accurately predict and stratify risk of hypertensive disorders of pregnancy regardless of race or ethnicity.

The findings come amidst growing use of the treatment approach.

This retrospective study shows that among nearly 160,000 patients with pulmonary hypertension (PH), those who also had gastroesophageal reflux disease (GERD) had lower rates of morbidity and mortality.

This small study showed that individuals who used an app designed specifically for smokers ambivalent about quitting used the app more often and exhibited greater changes in behavior compared with those using a similar nontailored app.

Although previous research has explored and documented the prevalence of stigma facing people with chronic skin conditions, less is known about how patients respond to such stigma.

This retrospective study showed that anti–interleukin-17 drug secukinumab yielded favorable results in a small group of patients with severe hidradenitis suppurativa (HS).

The researchers focused on coverage trends across an array of disease states, including lymphoma, vision loss, and spinal muscular atrophy, finding discrepancies in coverage across 16 states and Medicaid Care Organizations.

A rare condition that presents with refractory and many times super-refractory status epilepticus, NORSE, including its subtype febrile infection related epilepsy syndrome (FIRES), is heterogeneous without one single etiology.

The cross-sectional study of 260 people with epilepsy collected data between October and December 2020, months following the onset of the pandemic in the United States.

With Medicare-aged Americans accounting for over 15% of the population and significant health care costs, stakeholders have leveraged various approaches, including the Medicare Current Beneficiary Survey, for estimating costs.

The study, wrote the researchers, offers insight into emerging and uncommon complications following chimeric antigen receptor (CAR) T-cell therapy.

Deemed the “Medicare” effect, patients aged 65 years who have Medicare coverage had an increased incidence of head and neck squamous cell carcinoma (HNSCC) but were less likely to receive a late-stage diagnosis and had lower mortality rates.

Of the studies, 47% did not directly ask patients about financial difficulties associated with their cancer.

Pulmonary arterial hypertension (PAH) is the only major diagnostic indication for transplantation that is not a parenchymal pulmonary process.

The study, using an adaption of the World Health Organization framework for adherence, characterized strategies built into the design, conduct, and reporting of melanoma trials, offering insights into potential improvements for skin self-examination in research.

The researchers of a new study highlighted the unique financial burden facing these patients, eligible for hematopoietic stem cell transplantation (HSCT), who often require lengthy hospitalizations and have associated risks of acute and chronic morbidity.

Using a diverse human gut community, researchers investigated how gut microbiota interspecies interactions affected the response of Clostridioides difficile to vancomycin and metronidazole.

A Danish study of nationwide registries estimated a 39% greater risk of high refractive error among children of mothers with hypertensive disorder of pregnancy (HDP), a complication that affects 5% to 10% of pregnancies.

Patients in this study, who had overall significantly higher scores than controls, fell into 3 categories of psychological risk from temporal lobe epilepsy (TLE) based on analysis with unsupervised machine learning.

These insights represent the first characterization of risk factors for respiratory failure–related hospitalization among patients with sarcoidosis‐associated pulmonary hypertension (SAPH).

Subsequent testing revealed the presence of the variant in the patient’s siblings, also underscoring the importance of counseling family members who have pulmonary arterial hypertension (PAH).

The systematic review and meta-analysis showed no correlation between epilepsy surgery and intelligence quotient (IQ) or quality of life (QOL) among younger patients with facial cortical dysplasia (FCD) and long-term epilepsy-associated tumors (LEAT).

The findings from this single-center cross-sectional study, say the researchers, suggest that IL-6 signaling may be a promising target for the treatment of patients with glutamic acid decarboxylase (GADA)–induced autoimmune epilepsy.