Jaime is a freelance writer for The American Journal of Managed Care® (AJMC®), where she previously worked as an assistant editor.
She has a BA in print journalism from Penn State University. You can connect with Jaime on LinkedIn.
Thymectomy Reduces Hospital Stay From Myasthenia Gravis With Acute Exacerbation
The researchers note that this finding adds valuable insight for individualized treatment decisions in scenarios where the role of thymectomy is not fully clear.
Rates of Depression, Anxiety Higher in MG Than in Other Autoimmune Diseases
The systemic review and meta-analysis, believe the researchers, is the first of its kind to characterize the prevalence of depression among these patients.
Paxlovid May Reduce Already Low Risk of COVID-19 Hospitalization, Death Among Vaccinated Patients
Patients who received nirmatrelvir plus ritonavir (Paxlovid) had lower risk of both hospitalization within 14 days and death within 28 days compared with patients who did not receive the treatment.
Risk Prediction for Risk Mitigation in Prostate Cancer Explored in New Study
The importance of identifying rare pathogenic mutations and genetic risk score among patients was explored in this new analysis, with goals that included reducing mortality and early disease detection.
Prioritize Paxlovid for Unvaccinated Patients at High Risk of Severe COVID-19: Cost-effectiveness Analysis
A new analysis has determined the cost-effectiveness of nirmatrelvir/ritonavir (Paxlovid), granted emergency use authorization by the FDA, across various scenarios of vaccination status and risk for severe disease.
Secondary ADAPT Analysis Shows HRQOL Benefit of Efgartigimod in Myasthenia Gravis
Data from the secondary analysis show that the improvements seen in health-related quality of life (HRQOL) translated into clinical improvements.
COVID-19 May Accelerate Onset of Myasthenia Gravis, Case Study Suggests
The researchers hypothesize that SARS-CoV-2 infection may have triggered thymic inflammation, spearheading initial expression of muscle-like epitopes and T-cell dysregulation.
Severity of SMA Muscle Impairment Prior to Treatment May Have Implications for Nusinersen Efficacy
The findings, which the researchers say highlight the importance of early diagnosis and initiation of treatment, come amid efforts to determine efficacy trends among the several treatment options for the condition.
Repeated SMA Treatment With Nusinersen Does Not Result in Consistent Increase in Immune Responses
The findings, say the researchers, confirm that repeated intrathecal injections of the gene-targeting therapy are safe, adding to the limited data on the long-term effect and safety of the treatment approach in neurological diseases.
Managing GI Symptoms During OIT for Food Allergies
Though a large proportion of patients receiving oral immunotherapy (OIT) for food allergy report gastrointestinal (GI) symptoms, a knowledge gap remains for the best approach to determine the underlying etiology and manage symptoms.
Journey to SMA Diagnosis in Ireland Highlights Utility of Newborn Screening Program
Drawing on findings from other countries, including the United States, the group is highlighting the need for a newborn screening program to mitigate these current barriers.
Modified Elimination Diet May Be Effective in Children With Eosinophilic Gastrointestinal Disorders
Based on their retrospective findings, the researchers suggest the diet is a potentially effective option for these patients who may face challenges with other elimination diets.
Using Risk Factors to Guide CAR T Approach Before, After Infusion in B-ALL
This paper follows the 10-year remission mark for the first child treated with CD19-targeted CAR (chimeric antigen receptor) T-cell therapy for B-cell acute lymphoblastic leukemia (B-ALL), adding promise to the notion that the technology can provide long-term durable remissions in patients who are highly refractory to chemotherapy.
Children With Psoriasis Should Be Screened for Mental Health Conditions, Say Researchers
A review of available literature, although limited, has pointed to a link between pediatric psoriasis and anxiety and depression. Previous research has made a clear association between psoriasis and mood disorders in adults.
Researchers Find No Tumor Recurrence, Progression in Patients Receiving Biologic for Psoriasis
Data on the use of biologics for psoriasis among patients with a history of cancer have remained sparse. However, new findings provide the largest amount of real-world data on the use of the biologic secukinumab in these patients.
Multimorbidity May Increase Risk, Duration of Hospitalization for Patients With RA
With 60% to 75% of patients with rheumatoid arthritis (RA) developing other long-term conditions throughout their lifetime, the researchers underscored the importance of using multimorbidity in risk stratification of patients with RA based on their findings.
Systematic Review Highlights Inconsistent Evidence on Role of Diet in RA Risk
Generally, the studies suggested a decreased risk of rheumatoid arthritis (RA) associated with fish and vegetable consumption, as well as Mediterranean-style diets, although the researchers noted that these studies used varying methods and had varying results.
Predictors of Severe COVID-19 Infection, Mortality in Patients With MM, AL Identified
Their findings, say the researchers, offer useful insights into the outcomes and risks of severe disease and mortality in patients who have multiple myeloma (MM) or amyloidosis (AL) with underlying monoclonal gammopathy who contract COVID-19.
Women With CKD Receiving Fertility Treatment Have Similar Birth Rates to Those Conceiving Naturally
Researchers underscore a need for prospective data, noting that women with chronic kidney disease (CKD) tended to have higher rates of preterm delivery and lower birthweight.
MDD Treatment Alternatives Explore Potential of Cannabis, Psychedelics
Stemming from recent data on a potential link between major depressive disorder (MDD) and inflammation, research is starting to turn toward alternatives that can treat the disease through anti-inflammatory effects, including ketamine, cannabinoids, and psychedelics.
Motor Function Continues to Improve in Second Year of Risdiplam Treatment for SMA
Detailing findings from the secondary end points of the FIREFISH trial at 24 months, the researchers found that risdiplam treatment was associated with continued improvements in motor function and the achievement of development motor milestones.
Drops in Serum Phosphate Levels May Help Predict Severe CRS After CAR T
A new study has found that a drop in serum inorganic phosphate (iP) was an early predictor of severe cytokine release syndrome (CRS), suggesting that monitoring serum iP levels could help promote safer management of the most common toxicity associated with chimeric antigen receptor (CAR) T-cell therapy.
Certain CSF Biomarker May Foretell Nusinersen Response in Children With SMA
Using data from patients with spinal muscular atrophy (SMA) type 1 and 2, researchers observed that chitotriosidase 1 levels in cerebral spinal fluid (CSF) changed over time after treatment with nusinersen, suggesting that the change could be indicative of treatment response.
While Mortality Wanes for RA, Patients Still at Higher Risk of All-Cause Mortality
The observational study found that 25% of deaths were premature and that mortality associated with rheumatoid arthritis (RA) resulted from cardiovascular, cancer, and respiratory causes
Data Suggest Next-Gen BTK Inhibitor Is More Favorable in Rare Form of NHBCL
Zanubrutinib is the latest of 3 Bruton tyrosine kinase (BTK) inhibitors approved for rare B-cell malignancies, such as Waldenström macroglobulinemia, a non-Hodgkin B-cell lymphoma (NHBCL); as a next-generation BTK inhibitor, zanubrutinib is designed to have less off-target effects.
Researchers Provide Management Recommendations for CRS, Other Toxicities of CAR T
While chimeric antigen receptor (CAR) T-cell therapy has offered a new option and improved outcomes for patients with advanced hematologic malignancies, the treatment approach has been associated with toxicities such as cytokine release syndrome (CRS), neurotoxicity, and hematotoxicity.
Could Combining Use of BTK Inhibition, CAR T-Cell Therapy Yield Better Outcomes in MCL?
Recent research suggested the idea of combining chimeric antigen receptor (CAR) T-cell therapy and Bruton’s tyrosine kinase (BTK) inhibitors for certain patients with advanced mantle cell lymphoma (MCL).
Identifying SE in Initial Asthma Screening May Help Promote Precision Medicine
The retrospective findings showed that searching for Staphylococcus aureus and its enterotoxins (SE) when initially screening patients for asthma can help with identifying a targeted treatment option by improving phenotyping and predicting comorbidities.
Emerging Treatments Could Add to Targeted Options for Psoriasis, PsA
Emerging therapies for psoriasis and psoriatic arthritis (PsA) include treatments that target interleukin (IL)-23 and IL-17, which could lead to the approval of new IL-23 and IL-17 inhibitors, as well as expanding the use of currently approved options.
Study Supports Feasibility of Integrating Specialty Pharmacists in Health Systems
The program, serving patients from rheumatology, dermatology, gastroenterology, allergy, and cardiology clinics, is the first of its kind within the Veterans Health Administration, researchers said.
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