Jaime is a freelance writer for The American Journal of Managed Care® (AJMC®), where she previously worked as an assistant editor.
She has a BA in print journalism from Penn State University. You can connect with Jaime on LinkedIn.
Initiation of Nusinersen for SMA Soon After Birth May Allow for Normal Outcomes
July 2nd 2022Publishing their findings on the earliest treated infants to date, the researchers detailed the outcomes of 2 patients treated with nusinersen in their first week of life after receiving a spinal muscular atrophy (SMA) prenatal diagnosis.
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Comprehensive Analysis of SMA May Improve Detection, Lower Residual Risk Ratio
June 29th 2022The researchers of this new study wrote that although SMA carrier screening is recommended for all couples, current testing methods primarily focus on copy number loss of SMN1, which can result in false-negative test results due to intragenic mutations and silent carriers falling under the radar.
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Researchers Outline Use of Hormonal Therapies in Acne, Hidradenitis Suppurativa
June 25th 2022Combined oral contraceptives (COCs) and, more recently, spironolactone, have been identified as options for adolescent females with acne and hidradenitis suppurativa (HS), although varying levels of data are available supporting their use in these patients.
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Study Highlights Need for Validated Blood Biomarkers in PAH
June 23rd 2022Collecting more than 3 decades’ worth of data, researchers determined that none of the identified blood biomarkers are accurate enough to take the place of current diagnostic approaches, either due to lack of data or lack of specificity.
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High Economic Burden of MM, Particularly Within 1 Year of Diagnosis, Says French Study
June 4th 2022As more treatments continue to enter the market for multiple myeloma (MM), the cost of associated treatments is expected to continue climbing, with the researchers of the study emphasizing the need for more effective and options to help mitigate costs.
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Low Socioeconomic Status May Account for Ethnic Survival Disparities in MM
June 3rd 2022The researchers found that socioeconomic status likely drives survival disparities between Hispanic patients and non-Hispanic whites (NHWs). They also found that, while both underserved populations, Hispanics and non-Hispanic blacks have different survival outcomes compared with NHWs.
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Genetic Risk Scores for Alzheimer Disease May Have Implications for Parkinson Disease
May 30th 2022The findings from the study indicate that higher genetic risk score for Alzheimer disease (AD) are associated with cognitive declines in patients with Parkinson disease (PD), while higher genetic risk scores for PD signify an increased risk of PD, albeit with slower clinical progression after diagnosis.
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Researchers Establish, Validate Prognostic Model for Uveal Melanoma
May 28th 2022The model consists of 3 metabolism-related genes—carbonic anhydrase 12, acyl-CoA synthetase long-chain family member 3, and synaptojanin 2— that the researchers said could potentially be used as biomarkers and treatment targets in the disease.
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Increases in Inflammatory Markers, Leukocyte Profile May Impact HS Severity
May 20th 2022The findings come from a novel longitudinal analysis of 400 patients, which the researchers said validates and further underscores the utility of laboratory parameters for the management of hidradenitis suppurativa.
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Case Study: Caplacizumab May Salvage Refractory Immune TTP Following COVID-19 Vaccine
May 20th 2022While suggesting that the disorder be included in the differential diagnosis of thrombocytopenia following vaccination, the group emphasized that the benefits of global vaccination against the virus outweigh the risk of this rare complication.
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Serum IgG Subclass May Be Indicator of Treatment Effect in Multiple Myeloma
May 18th 2022The researchers found that among subclasses, IgG1 expression was most prominent in samples from patients with multiple myeloma, and expression of IgG1 changed significantly before, throughout, and following treatment.
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Repurposing a Drug Used for Alcohol Abuse May Overcome MM Treatment Resistance
May 15th 2022According to recent findings, metabolizing disulfiram into diethyldithiocarbamate-copper complex creates a proteasome inhibitor-like treatment that enables the efficient killing of treatment-resistant multiple myeloma (MM) cells.
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Researchers Call for Push to More Holistic, Collaborative Care for Young Adults With T1D
May 14th 2022The group noted that this transformation should affect changes at every level, including at the individual level during patient visits, at the organization level in how clinical encounters are organized, and at the national level in both policies and guidelines for type 1 diabetes (T1D).
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Pressure-Induced Increase in PD-L1 Expression May Dull Effect of CAR T-Cell Therapy
May 10th 2022The study of constructed αROR1‐CAR T cells showed an increase of PD-L1 expression when exposed to elevated pressure, driving resistance to CAR T cell-mediated cytotoxicity. However, the findings also suggest that adding PD-1/PD-L1 inhibitors to CAR T-cell therapy could help address this.
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