Jaime is a freelance writer for The American Journal of Managed Care® (AJMC®), where she previously worked as an assistant editor.
She has a BA in print journalism from Penn State University. You can connect with Jaime on LinkedIn.
Study Underscores Need for Optimal RV Function Measures in PH
March 18th 2023Right ventricular (RV) dysfunction has previously been linked to symptoms and mortality in pulmonary hypertension (PH), as well as in other conditions, and RV function plays an important role in disease risk and potentially in intensification of pulmonary arterial hypertension treatment.
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Noninvasive Predictors of Pulmonary Hypertension in Interstitial Lung Disease Identified
March 11th 2023The researchers noted that their study is the first to assess the ability of noninvasive variables, both resting- and exercise-based, to identify pulmonary hypertension in interstitial lung disease.
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Rare Risk of Acquired Hemophilia A Seen Following COVID-19 Infection, Vaccination
March 11th 2023A group of researchers detailed a case of acquired hemophilia A (AHA) following infection and again following vaccination, and provided additional insights through their systematic review of available data.
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FVIII Half-life in Patients With Hemophilia Largely Determined by Clearance of VWF
March 10th 2023These new findings suggest that variability in factor VIII (FVIII) half-life in patients, though impacted by all 3 factors, is largely attributed to variability in the clearance of endogenous von Willebrand factor (VWF).
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Screening Protocols During Early Phase of COVID-19 Improved Outcomes in MM
March 6th 2023Researchers retrospectively analyzed data from patients who visited 2 myeloma centers between March and October 2020, before vaccines were widely available but during large-scale implementation of regular screening processes.
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Nusinersen Modulates Neuroinflammation in Severe SMA, Study Says
March 4th 2023Researchers of the multicenter study looked at the effect of nusinersen among 48 patients with spinal muscular atrophy (SMA) from 2 Italian hospitals, finding more active immune systems among the patients with SMA1, the most severe form of the disorder.
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Impaired Exercise Capacity From PAH-CHD Most Prominent in Patients With Eisenmenger Syndrome
February 25th 2023Study findings offer insight into how exercise intolerance varies among subgroups of pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD), as previous data have characterized impaired exercise tolerance among PAH-CHD as a whole.
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Novel Machine Learning Model May Detect Pulmonary Hypertension Earlier
February 24th 2023Having a diagnostic model that leverages artificial intelligence could fill a gap in the pulmonary hypertension (PH) diagnostic pathway, as there are currently just 2 validated screening algorithms for PH.
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Andexanet Alfa Fully Neutralizes Anticoagulation From Thrombotic Disorder Treatment
February 22nd 2023Researchers found that the anticoagulant effects of apixaban, betrixaban, edoxaban, and rivaroxaban were partially neutralized at an andexanet alfa dose of 50 mcg/mL and were completely neutralized at 100 mcg/mL.
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NGS-Based Assay Shows Feasibility, Potential Cost Savings in Newborn SMA Screening
February 18th 2023Investigators note that although the overall cost for implementing next-generation sequencing (NGS) testing would be more than implementing current polymerase chain reaction (PCR)–based testing, the assay may be more cost effective overall because it screens for multiple conditions.
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Real-World Data Show Most Nusinersen Doses Administered on Time
February 17th 2023The data showed that most doses of nusinersen were received on time while also underscoring the importance of being meticulous with the methodological approaches used with real-world databases for evaluating treatment patterns.
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Cases of SCC-Related Hospitalizations Increasing Among Patients With Multiple Myeloma
February 15th 2023Throughout this study's 12-year period, the average annual percent change showed an uptrend for all groups in hospitalization for spinal cord compression (SCC), and this was higher for non-Hispanic Black patients vs Hispanic patients and non-Hispanic White patients.
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FVIII Inhibitory Antibody Titer Shows Implications for Response to IST Treatment for AHA
February 13th 2023Data show that patients who have factor VIII (FVIII) inhibitor titers of 20 or higher BU/mL took longer to achieve complete responses (CR) and had lower CR rates vs patients with lower titers.
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Despite High False-Positive Rate of FIT, Patients With Hemophilia Have High CRC Detection Rate
February 11th 2023The researchers underscored the importance of their findings for a wide group of patients with inherited bleeding disorders, as most colorectal cancer (CRC) screening programs across the globe use fecal immunochemical testing (FIT).
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Improving SMA HRQOL Must Address Patient and Caregiver Well-being
February 7th 2023Data from 2 prospective studies showed correlations between impaired patient health-related quality of life (HRQOL) and disease severity, as well as correlations between the health of caregivers and their HRQOL and caregiver burden.
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Nationwide Data Show Delayed Correct Diagnosis for PAH
February 6th 2023The long time to diagnosis is consistent with data pointing to pulmonary arterial hypertension (PAH) often being misdiagnosed as asthma, said the researchers, adding that the findings from their retrospective study provide valuable insight into where the diagnostic pathway lags.
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Certain Patient Groups Continue to Be Underrepresented in PD Studies in the Netherlands
February 4th 2023With greater attention being paid to the heterogenous patient population, researchers questioned whether this has resulted in a more diverse group of patients included in Parkinson disease (PD) studies in the Netherlands.
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Including MRD Status Reduces Uncertainty in Long-term Survival Models of NDMM
February 3rd 2023Having models like these that produce more plausible results are crucial for decision-making in an era of targeted treatments that often come with immature data, argued researchers of their findings for minimal residual disease (MRD) in newly diagnosed multiple myeloma (NDMM).
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