The first drug to treat primary progressive multiple sclerosis and a new drug approved for atopic dermatitis are the 2017 approvals most exciting to Aimee Tharaldson, PharmD, of Express Scripts.
Transcript
What drugs expected to be approved in 2017 are most exciting to you?
You know it’s interesting, the 2 drugs that I think are going to be key this year, are expected to be approved today. Actually, one drug is Ocrevus. This is going to be the first drug approved to treat primary progression MS. It’s also in development for relapsing forms of MS. So it’s a biologic drug. It’s given every 6 months. In clinical trials for relapsing forms of MS, they compared it to Rebif, and it reduced relapse rates by about 40% compared to Rebif. They looked at it in primary progression MS and it reduced disability progression by about 25% compared to placebo. So it’s a very effective medication.
There is a safety signal to watch for in the primary progressive MS trial. It did cause tumors in 2.3% of patients, which is twice as much as the placebo group. So that will have to be monitored carefully. It may have a box warning concerning this risk.
But watch for Ocrevus today.
And another drug, which we were expecting to be approved tomorrow, just got approved about an hour or so ago: Dupixent, or dupilumab. So this is a biologic drug to treat patients with moderate to severe atopic dermatitis, who aren’t well controlled on currently available topical therapies like glucocorticoids or calcineurin inhibitors, like Protopic or Elidel. So there’s 300,000 or more patients in the United States right now who could be candidates for treatment with Dupixent.
The manufacturer did release pricing. It’s going to be $37,000 per year. So this is a medication that’s going to be used chronically in these patients. Very effective medication. Can be used alone or in combination with topical glucocorticoids. So I don’t know exactly the launch date of that product, but I imagine it will reach the market pretty soon.
The Importance of Examining and Preventing Atrial Fibrillation
August 29th 2023At this year’s American Society for Preventive Cardiology Congress on CVD Prevention, Emelia J. Benjamin, MD, ScM, delivered the Honorary Fellow Award Lecture, “The Imperative to Focus on the Prevention of Atrial Fibrillation,” as the recipient of this year’s Honorary Fellow of the American Society for Preventive Cardiology award.
Listen
Oncology Onward: A Conversation With Dr Shereef Elnahal, Under Secretary for Health
April 20th 2023Shereef Elnahal, MD, MBA, under secretary for health at the Veterans Health Administration (VHA), sat for a conversation with our hosts Emeline Aviki, MD, MBA, Memorial Sloan Kettering Cancer Center, and Stephen Schleicher, MD, MBA, Tennessee Oncology, that covered the cancer footprint of the VHA.
Listen
Distinguishing Biomarkers Identified in MS Outcomes
March 19th 2024Results from this cohort study found that levels of glial fibrillary acid protein, cerebral spinal fluid, and neurofilament heavy chain are distinguishable biomarkers that are associated with disease outcomes in multiple sclerosis (MS).
Read More