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Studies Are Showing SGLT2s Also Help Control Hypertension, Eliminate Some Side Effects

Andrew Smith
Real-world studies of SGLT2 inhibitors show that this new class of drugs for type 2 diabetes has lowered A1C more than rivals. Patients lose more weight than with other oral therapies, and the benefit of controlling hypertension may make it possible for some patients to stop taking other drugs.
• an enhanced pharmacovigilance program that monitors malignancies, serious cases of pancreatitis, severe hypersensitivity reactions, photosensitivity reactions, liver abnormalities, and adverse pregnancy outcomes
• a pediatric pharmacokinetic and pharmacodynamic study
Those same trials, meanwhile, have clearly demonstrated that SGLT2 inhibitors produce unique benefits and may thus prove to be considerably more useful than many originally expected.

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16. Merck announces 4th quarter and full year 2013 results [press release]. Whitehouse Station, NJ: Business Wire; February 5, 2014.
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18. Invokana website. Invokana monotherapy provided statistically significant reductions in A1C vs placebo at 26 weeks. Accessed February 17, 2015.
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24. FDA approves Invokana to treat type 2 diabetes [press release]. Silver Spring, MD: FDA Newsroom; March 23, 2013.
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