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Evidence-Based Diabetes Management June 2018
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CHAPTER 2. Clinical Nutrition Guideline for Overweight and Obese Adults With Type 2 Diabetes (T2D) or Prediabetes, or Those at High Risk for Developing T2D
Osama Hamdy, MD, PhD; Om P. Ganda, MD, Chair, Clinical Oversight Committee; Melinda Maryniuk, MEd, RD, CDE; Robert A. Gabbay, MD, PhD, FACP; and the members of the Joslin Clinical Oversight Committee
Clinical Oversight Committee, Joslin Diabetes Center
Om P. Ganda, MD; and Robert A. Gabbay, MD, PhD, FACP
CHAPTER 1. Clinical Guideline for Adults With Diabetes
Samar Hafida, MD; Om P. Ganda, MD, Chair, Clinical Oversight Committee; Robert A. Gabbay, MD, PhD, FACP; and the members of the Joslin Clinical Oversight Committee
CHAPTER 3. Guideline for Detection and Management of Diabetes in Pregnancy
Florence M. Brown, MD; Sue-Ellen Anderson-Haynes, RD, CDE; Elizabeth Blair, MSN, ANP-BC, CDE, CDTC; Shanti Serdy, MD; Elizabeth Halprin, MD; Anna Feldman, MD; Karen E. O'Brien, MD; Sue Ghiloni, RN, CDE; Emmy Suhl, MEd, RD, CDE; Jo-Anne Rizzotto, MEd, RD, CDE; Om P. Ganda, MD, Chair, Clinical Oversight Committee; Robert A. Gabbay, MD, PhD, FACP; and members of the Joslin Clinical Oversight Committee, with administrative support from Breda Curran
CHAPTER 4. Guideline for the Care of the Older Adult With Diabetes
Medha Munshi, MD; Elizabeth Blair, MSN, ANP-BC, CDE, CDTC; Om P. Ganda, MD, Chair, Clinical Oversight Committee; Robert A. Gabbay, MD, PhD, FACP; and the members of the Joslin Guidelines Committee
CHAPTER 5. Clinical Guideline for Pharmacological Management of Adults With Type 2 Diabetes
Om P. Ganda, MD, Chair, Clinical Oversight Committee; Alissa Segal, PharmD, CDE, CDTC; Elizabeth Blair, MS, ANP-BC, CDE, CDTC; Richard Beaser, MD; Jason Gaglia, MD; Elizabeth Halprin, MD; Robert A. Gabbay, MD, PhD, FACP; and the members of the Joslin Clinical Oversight Committee

CHAPTER 2. Clinical Nutrition Guideline for Overweight and Obese Adults With Type 2 Diabetes (T2D) or Prediabetes, or Those at High Risk for Developing T2D

Osama Hamdy, MD, PhD; Om P. Ganda, MD, Chair, Clinical Oversight Committee; Melinda Maryniuk, MEd, RD, CDE; Robert A. Gabbay, MD, PhD, FACP; and the members of the Joslin Clinical Oversight Committee
From the Adult Diabetes and Clinical Research sections, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts. 
Objective. The Joslin Clinical Nutrition Guideline for Overweight and Obese Adults With Type 2 Diabetes (T2D) or Prediabetes, or Those at High Risk for Developing T2D is designed to assist primary care physicians, specialists, and other healthcare providers in individualizing the care of and setting goals for adult, nonpregnant patients with T2D or individuals at high risk for developing the disease. This guideline focuses on the unique needs of those individuals. Several components complement the 2015-2020 Dietary Guidelines for Americans. The Dietary Guidelines for Americansare jointly developed every 5 years by the US Department of Health and Human Services and the US Department of Agriculture. This Guideline is not intended to replace sound medical judgment or clinical decision making and may need to be adapted for certain patient-care situations where more or less stringent interventions are necessary. This guideline was approved October 19, 2016; updated on January 28, 2018.


TABLE 1. Individuals Targeted for Intervention Meet 1 Criterion in Each of 2 Categories


  • There is strong evidence that weight reduction improves insulin sensitivity and glycemic control, lipid profile, and blood pressure in T2D, and decreases the risk of developing T2D in prediabetes and high-risk populations [1A].
  • Refer individuals to a registered dietitian (RD) experienced in diabetes and weight management for individualized medical nutrition therapy (MNT); care should be coordinated with an interdisciplinary team including the patient’s primary care physi- cian (PCP) [1B].
    • To enhance effectiveness of MNT, a series of 3 to 4 encounters with an RD, each lasting 45 to 90 minutes, is recommended to begin at diagnosis
  • Priorities for this population include:
    • Weight reduction
    • Glycemic control as well as achieving blood pressure and low-density lipoprotein cholesterol goals
    • Meal-to-meal consistency in carbohydrate distribution for those with fixed medication/ insulin programs
    • Individualization for cultural and food preferences (eg, vegetarian)
    • Adoption of a healthy eating pattern that is sustainable over time. The Mediterranean diet, the DASH [Dietary Approaches to Stop Hypertension] diet, and a plant-based or vegetarian diet are examples of healthy dietary patterns
    • Integration of behavior-change therapies to adopt healthy eating behaviors and sustainable weight loss
  • The meal plan composition, described below, is for general guidance only and may be individualized by the RD or other healthcare provider according to clinical judgment, individual (patient) preferences and needs, and metabolic response.
  • Physical activity is an integral component of a weight loss program for both initial weight loss and for weight maintenance.


  • A structured lifestyle plan that combines dietary modification, activity, and behavioral modification, along with ongoing support, is necessary for weight reduction [1B]. To maintain long-term weight loss, ongoing weight-maintenance counseling and support is recommended.
  • A modest and gradual weight reduction of 1 to 2 pounds every 1 to 2 weeks should be the optimal target [2A]. Reduction of daily caloric intake should be between 250-750 calories [1C]. Total daily intake should not be less than 1000 to 1200 calories for women and 1200 to 1600 calories for men, or based on an RD assessment of usual intake [1C].
  • A 5% to 10% weight loss may result in significant improvement in blood glucose control among patients with diabetes and may help prevent the onset of diabetes among individuals with prediabetes [1B]. Weight reduction should be individualized and continued until an agreed-upon BMI and/or other metabolic goals are reached.
  • Target individuals should meet with an RD to discuss a structured MNT plan for weight management that includes menus and snacks as well as education and practice in portion control, all effective components of weight-management plans [1B].
  • Diabetes-Specific Meal Replacements (DSMRs) in the form of shakes, bars, ready-to-mix powders, and prepackaged meals that match these nutrition guidelines may be effective in initiating and maintaining weight loss.
    • Meal replacements should be used under the supervision of a RD
    • When meal replacements are initiated, glucose levels should be carefully monitored and, if needed, antihyperglycemic medications should be adjusted
    • Meal replacements should be used with caution by those with hyperkalemia
  • Bariatric surgeries, although not without medical and nutrition risks, are effective options and may be discussed when indicated (consider in individuals with BMI ≥40 kg/m2 and those with BMI ≥35 kg/m2 with other comorbidities. Reduce calculations by 2.5 kg/m2 for Asians) [2B]. To date, there is limited evidence to support the recommendation of bariatric surgeries for patients with BMI <35 kg/m2 even if a person has diabetes or other comorbid conditions.
  • Anti-obesity medications may be considered for patients who were not able to lose weight through lifestyle modifications, but the long-term risks and benefits of these medications are unclear [2C].
  • The effect of diabetes medications should be evaluated throughout the weight loss program and adjusted as necessary to avoid hypoglycemia.


2.4.1 Fat:

Amount. There is general agreement that the type of fat consumed is more important than the quantity (generally 30% to 40% of total calories). Trans fats from partially hydrogenated oil should be eliminated [1B].
  • Monounsaturated and polyunsaturated fats should comprise the majority of fat intake [2B].
  • Limit saturated fat intake to <10% of total calories.
    • Recent evidence demonstrates that saturated fat from dairy foods (milk, yogurt, cheese) may be acceptable within the total daily caloric intake [2B] 
    • Despite recent evidence suggesting that saturated fat poses a weak or neutral effect on health, further research in this area is warranted
  • Low-fat diets are generally less effective than low- carbohydrate diets for weight reduction [2C]
  • Plant fats rich in mono- and polyunsaturated fats (eg, olive oil, canola oil, soybean oil, nuts/seeds, and avocado) [2A]
  • Oily fish rich in omega-3 fatty acids (eg, salmon, herring, trout, sardines, fresh tuna) 2 times/week, as a source of these fatty acids [2B]
Not recommended.
  • Foods high in saturated animal fat, including nonlean pork, lamb, and beef; processed meat; butter and cream
  • Foods high in trans fats (eg, most fast foods; most commercially baked goods; margarines from partially hydrogenated oil)
2.4.2 Protein

Amount. Protein intake should range between 1.0-1.5 grams/kg of adjusted body weight. To calculate adjusted body weight, first calculate excess weight: Excess weight = current weight – ideal body weight (IBW). Adjusted body weight = IBW + 0.25 of excess body weight. This amount generally accounts for 20% to 30% of total caloric intake.
  • A modest increase in protein reduces appetite and helps achieve and maintain weight reduction [2B]. Protein also helps minimize loss of lean body mass during weight reduction [2B].
  • No reliable scientific data support a protein intake that exceeds 2 grams/kg of adjusted body weight. Conversely, reduction of protein intake to less than 0.8 grams/kg day may result in protein malnutrition.
Recommended. Fish, skinless poultry, lean meat, dairy, egg whites, nuts, seeds, soy, and other legumes [2B].

Not Recommended. Sources of protein that are high in saturated fat (eg nonlean pork, lamb, beef; processed meats) as they may be associated with increased cardiovascular risk[1B]. Heme iron in meat is also associated with an increased risk of T2D [2B].

Patients with renal issues. Although reducing total calories may result in a reduction of the total amount of protein intake, any patient with signs of kidney disease (both of the following: proteinuria; estimated glomular filtration rate <60 ml/min) should consult a nephrologist before increasing the total or percentage of protein in their diet [1B]. Protein intake for these patients should be modified, but not lowered to a level that may jeopardize their overall health or increase their risk for malnutrition or hypoalbuminemia.

2.4.3 Carbohydrate

Amount. The total daily intake of carbohydrate should be at least 130 grams/day and preferably 40% to 45% of the total caloric intake. Intake should be adjusted to meet the cultural and food preferences of the individual.

Consideration of glycemic index/glycemic load. The glycemic index/glycemic load is an important factor that patients should apply in their daily selection of carbohydrate foods. Foods with a lower glycemic index content should be selected [2B] (eg, whole grains, legumes, fruits, green leafy and nonstarchy vegetables, milk, yogurt).

Recommended. Green leafy and nonstarchy vegetables, whole fruits, legumes, whole and minimally processed grains, oats, milk, yogurt [2B].

Not recommended. 
  • Sugar, or added sugar, especially sugar-sweetened beverages, ice cream, candies, and grain-based desserts. Milk chocolate should be avoided.
  • Refined grain products including white bread, white pasta, white rice, low-fiber wheat cereal, cakes, muffins, pizza. White bagels should be limited.
  • High glycemic-index carbohydrates, including white potatoes and white rice.
  • Approximately 14 grams of fiber/1000 cal (20-35 grams) per day is recommended [1C]. If tolerated, approximately 50 grams/day is effective in improving postprandial hyperglycemia; that quantity should be encouraged [2B].
  • Fiber from unprocessed plant-based food, such as vegetables, fruits, seeds, nuts, and legumes, is preferable. However, if needed, fiber supplements such as psyllium, resistant starch, and β-glucan can be added [2B].


Sodium. Daily consumption should be <2300 mg (about 1 tsp of salt) per day [1A]. Further reduction to 1500 mg is recommended in people aged >50 years, especially those including those with hypertension or chronic kidney disease [2B].

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