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Is Immunotherapy the Future of Glioblastoma Treatment?
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Is Immunotherapy the Future of Glioblastoma Treatment?

Samantha DiGrande
Immunotherapy has seen great success in the treatment of numerous cancers, from melanoma to lung, breast, colorectal, kidney, and even some brain cancers. But thus far, despite several attempts, the devastating brain disease glioblastoma has not been among the immunotherapy success stories. In fact, glioblastoma researchers have had few advances in more than a decade.
The vaccine DCVax-L is currently being tested in a phase 3 trial involving patients with glioblastoma whose tumors could be removed surgically. It uses dendritic cells (a type of immune cell) that are engineered to provoke an immune response against multiple proteins, or antigens, on tumors.20

Additionally, researchers are looking at oncolytic virus therapy as a potential treatment for glioblastoma. Originally, these viruses were developed as therapies to directly infect and kill cancer cells; however, investigators now believe that these viruses work similarly to vaccines and are able to stimulate an immune response against tumors.

“I think that there has been a lot of active, ongoing research, and the fact that we make breakthroughs in other cancers makes us more resolute in our drive and hopes to find help for patients with glioblastoma, and finding a cure,” said Lim.

Mary Caffrey contributed to this report.

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