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Time to Fecal Immunochemical Test Completion for Colorectal Cancer
Cameron B. Haas, MPH; Amanda I. Phipps, PhD; Anjum Hajat, PhD; Jessica Chubak, PhD; and Karen J. Wernli, PhD
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Time to Fecal Immunochemical Test Completion for Colorectal Cancer

Cameron B. Haas, MPH; Amanda I. Phipps, PhD; Anjum Hajat, PhD; Jessica Chubak, PhD; and Karen J. Wernli, PhD
Targeted interventions by patient characteristics to improve fecal immunochemical test completion could reduce disparities in colorectal cancer screening and improve overall compliance with screening recommendations.
Our findings regarding differences by race/ethnicity contrast with those of previous studies, which have suggested lower rates of CRC screening among people of color and lower completion of FITs, specifically for black and Hispanic individuals.39,40 Burnett-Hartman et al evaluated in stratified analyses the entire PROSPR network, indicating disparities in completion by race39; our results, however, support results in stratified analysis suggesting that Asian/Pacific Islanders are the earliest both to complete a FIT and to complete CRC screening overall. Results by other racial groups are similar to the stratified analysis but not for the pooled analysis reflective of larger samples in other systems. In our population, non-Hispanic black patients were more likely to complete FIT screening than non-Hispanic white patients. This is contrary to findings of previous studies, which have stated that a considerable proportion of the disparities in overall CRC survival between black and white patients might be attributable to differences in screening.41 However, our results are consistent with those of a recent randomized clinical trial that found that nonwhite participants were more likely to adhere to gFOBT than white participants, whereas white participants adhered more often to colonoscopy.42 As use of colonoscopy is generally more common than gFOBT/FIT for CRC screening in fee-for-service systems, this could explain part of the overall disparity in CRC screening adherence among minority populations.

It is important to note that completing a FIT is only 1 step in the CRC screening continuum, and a positive FIT requires a follow-up colonoscopy, which might incur out-of-pocket costs, even for insured patients.43 The potential for disparities in such follow-up merits further investigation. A recent study conducted at KPWA using mailed FITs and support over the phone was shown to double the number of adults who were currently compliant with CRC screening recommendations.27 Mailed outreach was effective for improving rates of CRC screening among underserved populations and had a markedly higher effect on screening with FITs compared with invitation for colonoscopy.44 Results from another study suggested that improved CRC screening will most likely be achieved through optimizing the time during current primary care visits rather than through outreach to encourage patients to attend primary care visits.42,45

Strengths and Limitations

Our study has several strengths in methodology, including a sufficient sample size to evaluate patient characteristics, data systems to capture return of FIT kits with a contemporary sample, and ability to ascertain patient covariates as confounders in the analysis. However, there are some limitations because of our study population that may limit the generalizability of our findings. It is important to recognize that ours is an insured population. Our results might not reflect the experience of uninsured or underinsured adults who may not have access to consistent healthcare. As a screening test, a FIT is a covered service under the Affordable Care Act; thus, included members should not have experienced any direct expense associated with completing a FIT during the study period.1,46 Despite federally mandated coverage, nonparticipation in CRC screening has been shown to be associated with concern for out-of-pocket costs among insured people with low socioeconomic status or in racial minority populations.43 However, for those who are uninsured, FIT use may be the most economically feasible method of receiving CRC screening. We primarily investigated patient characteristics for which previous research has asserted disparities in screening compliance. The VDW is limited in the ability to explore the reasons behind the observed patterns, but this research provides an important groundwork for future design for interventions to improve overall completion.

CONCLUSIONS

To our knowledge, this is the first study to assess screening completion based on return of FITs following clinician order. This research is important to reach the Healthy People 2020 goal of 70.5% completion of CRC screening and is a valuable contribution to the existing knowledge on CRC screening to reduce underuse.37 We have demonstrated that among adults eligible for CRC screening, the majority of those who complete the test do so within 2 weeks of the order. Of note, we did observe higher rates of FIT completion by nonwhite race/ethnicity. Targeted interventions, beyond mailed kits, and clinic workflows to improve return of FITs should be investigated as potential means to increase overall return rates and address disparities by patient characteristics such as obesity and age.

Acknowledgments

This study’s contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute, the National Institutes of Health, or the Agency for Healthcare Research and Quality.

Author Affiliations: Kaiser Permanente Washington Health Research Institute (CBH, JC, KJW), Seattle, WA; Department of Epidemiology, University of Washington (CBH, AIP, AH, JC), Seattle, WA; Fred Hutchinson Cancer Research Center (CBH, AIP), Seattle, WA.

Source of Funding: Research in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number U54 CA163261 and award number T32 CA094880 (“Cancer Prevention Training: Epidemiology, Nutrition, Genetics & Survivorship”) to Mr Haas.

Author Disclosures: Drs Chubak and Wernli are employees of Kaiser Permanente Washington, have received several grants on colorectal cancer, and present on colorectal cancer research at meetings and conferences. The remaining authors report no relationship or financial interest with any entity that would pose a conflict of interest with the subject matter of this article.

Authorship Information: Concept and design (CBH, AH, KJW); acquisition of data (JC, KJW); analysis and interpretation of data (CBH, AIP, JC, KJW); drafting of the manuscript (CBH, AIP, KJW); critical revision of the manuscript for important intellectual content (CBH, AIP, AH, JC, KJW); statistical analysis (CBH); provision of patients or study materials (KJW); obtaining funding (JC, KJW); administrative, technical, or logistic support (KJW); and supervision (AH, KJW).

Address Correspondence to: Cameron B. Haas, MPH, Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste 1600, Seattle, WA 98101. Email: haas.c@ghc.org.
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