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Supplements Cost-Effectiveness of Disease- Modifying Therapies in Multiple Sclerosis: A Managed Care Perspective

Overview and Diagnosis of Multiple Sclerosis

Samuel F. Hunter, MD, PhD
     When measuring the burden of MS, it is also important to consider impairment and disability related to symptoms and health-related quality of life (HRQoL), or the degree to which the disease affects a patient’s selfreported life perception. Results from a study evaluating HRQoL with the Short Form-36 in patients with MS (N = 57) showed that unemployment, smoking, and night      Besides a thorough history and physical examination, diagnostic tools used to diagnose MS and exclude other diagnoses include the gold standard test, which is an MRI, and may include CSF analysis and evoked potential testing. Importantly, phenotype classifications have been modified in an effort to improve the characterization of the clinical course of the disease and to better define study populations. Although MS is not curable, QoL can be substantially improved or at least maintained by early diagnosis and management strategies aimed at reducing relapses, postponing worsening of disease and disability, and addressing psychosocial issues of the patient with MS.

Author affiliation: Advanced Neurosciences Institute, Franklin, TN; NeuroNexus Center, Neurology Research, Novel Pharmaceutics Institute, Franklin, TN; Department of Neurology, Vanderbilt
University School of Medicine, Nashville, TN.
Funding source: This activity is supported by educational grants from Novartis Pharmaceuticals Corporation and Genzyme, a Sanofi Company.
Author disclosure: Dr Hunter reports serving as a consultant for AbbVie, Bayer, Genentech/Roche, and Sanofi-Genzyme. He also reports multicenter clinical research trial participation for Adamas,
Biogen, Genentech/Roche, and Teva. Dr Hunter has received research grant support from Sanofi-Genzyme, and has served on speakers’ bureaus for Mallinckrodt, Novartis, Sanofi-Genzyme, and Teva.
Authorship information: Concept and design; drafting of the manuscript; critical revision of the manuscript for important intellectual content; and supervision.
Address correspondence to: sfhunter@neurosci.us.
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